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Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
Non returnable*
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Composition

GLIMEPIRIDE-4MG

Manufacturer/Marketer

Eris Lifesciences Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Glimisave 4 Tablet 15's

Glimisave 4 Tablet 15's belongs to a class of antidiabetic called 'sulfonylureas' used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

The Glimisave 4 Tablet 15's contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Take Glimisave 4 Tablet 15's as prescribed by your doctor. Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, coma & low glucose levels. Most of these side effects of Glimisave 4 Tablet 15's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Glimisave 4 Tablet 15's should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Glimisave 4 Tablet 15's abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Glimisave 4 Tablet 15's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Uses of Glimisave 4 Tablet 15's

Type 2 diabetes

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Glimisave 4 Tablet 15's is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination. Glimisave 4 Tablet 15's can be combined with insulin or other forms of oral antidiabetic medication. Glimisave 4 Tablet 15's decreases blood sugar levels in a diabetic patient by increasing the production and secretion of insulin from the pancreas beta cells. Thus, it helps in controlling increased blood sugar levels after the meal.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Glimisave 4 Tablet 15's

  • Allergic reactions
  • Headache
  • Nausea
  • Blood pressure drop
  • Shock
  • Abnormal liver function
  • Including skin and eye yellowing (jaundice)
  • Bile flow issues (cholestasis)
  • Liver inflammation (hepatitis) or failure of the liver

Drug Warnings

Before taking Glimisave 4 Tablet 15's, inform your doctor if you are healing from injury, had or going to have surgery, have fever infections or other sources of stress, then contact your doctor as it might be appropriate to adjust care temporarily. If you have a serious kidney/liver disease, breastfeeding or pregnant, consult the doctor before using Glimisave 4 Tablet 15's. Do not take Glimisave 4 Tablet 15's if you are allergic to sulpha drugs, glimepiride, or any other antidiabetic medicines or have a deficiency of glucose 6-phosphate dehydrogenase (G6PD). A heart disease patient should consult a doctor before taking the Glimisave 4 Tablet 15's as it may worsen the heart disease's current conditions. Do not take Glimisave 4 Tablet 15's with oral contraceptives as it may increase blood sugar levels. On the other hand, taking Glimisave 4 Tablet 15's with pain killers like aspirin or ibuprofen can lower your blood sugar.

Drug-Drug Interactions

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GlimepirideCitalopram
Severe
GlimepiridePromazine
Severe

Drug-Drug Interactions

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GlimepirideCitalopram
Severe
How does the drug interact with Glimisave 4 Tablet:
Taking Glimisave 4 Tablet with Citalopram may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Glimisave 4 Tablet can be taken with Citalopram if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepiridePromazine
Severe
How does the drug interact with Glimisave 4 Tablet:
When Glimisave 4 Tablet is taken with Promazine may interfere with blood glucose control and reduce the effectiveness of Glimisave 4 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Glimisave 4 Tablet and Promazine, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much urine you're producing. If you notice any of these signs - very high or very low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideMiconazole
Severe
How does the drug interact with Glimisave 4 Tablet:
Co-administration of Miconazole with Glimisave 4 Tablet may increase the blood levels and effects of Glimisave 4 Tablet leading to low blood glucose levels.

How to manage the interaction:
Although there is a possible interaction between Miconazole and Glimisave 4 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat Consult a doctor immediately. Do not stop using medications without a doctor's advice.
GlimepirideIndometacin
Severe
How does the drug interact with Glimisave 4 Tablet:
Taking indomethacin with Glimisave 4 Tablet may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Glimisave 4 Tablet can be taken with indomethacin if prescribed by the doctor. Consult the doctor if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat.
GlimepirideLeflunomide
Severe
How does the drug interact with Glimisave 4 Tablet:
Co-administration of Leflunomide may increase the blood levels and effects of Glimisave 4 Tablet.

How to manage the interaction:
Although there is a possible interaction, Glimisave 4 Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor if your condition changes or you experience increased side effects. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideGrepafloxacin
Severe
How does the drug interact with Glimisave 4 Tablet:
Co-administration of Glimisave 4 Tablet with Grepafloxacin can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Although there is a possible interaction between Glimisave 4 Tablet and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience any of these symptoms - low blood sugar, headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideKetoprofen
Severe
How does the drug interact with Glimisave 4 Tablet:
Taking Ketoprofen with Glimisave 4 Tablet may increase the risk of hypoglycemia (low blood sugar).

How to manage the interaction:
Although there is a possible interaction, Glimisave 4 Tablet can be taken with Ketoprofen if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not taking the medications without consulting a doctor.
GlimepirideNalidixic acid
Severe
How does the drug interact with Glimisave 4 Tablet:
When Glimisave 4 Tablet is taken with Nalidixic acid, can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
There may be a possibility of interaction between Glimisave 4 Tablet and Nalidixic acid, but it can be taken if prescribed by a doctor. It's important to monitor your blood sugar levels closely. If you experience symptoms like kidney problems, low or high blood sugar, or other concerning symptoms, contact a doctor right away. They may be able to suggest alternative medications that won't interact with a diabetes treatment. Do not discontinue any medications without consulting a doctor.
GlimepirideCinoxacin
Severe
How does the drug interact with Glimisave 4 Tablet:
Co-administration of Glimisave 4 Tablet with Cinoxacin can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Although there is an interaction between Glimisave 4 Tablet and Cinoxacin can lead to an interaction. However, consult a doctor immediately if you experience any symptoms of hyperglycemia such as increased thirst, increased hunger, and increased urination of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
GlimepirideSparfloxacin
Severe
How does the drug interact with Glimisave 4 Tablet:
Co-administration of Sparfloxacin with Glimisave 4 Tablet can affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Glimisave 4 Tablet can be taken with Sparfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat (or) symptoms of high blood sugar like increased thirst, increased hunger, and increased urination. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low fat and a low sugar diet. Replace carbohydrates containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

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Author Details

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Drug-Diseases Interactions

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GLIMEPIRIDE-4MGHypertensive heart and renal disease
Severe
GLIMEPIRIDE-4MGUnspecified kidney failure
Severe

Drug-Diseases Interactions

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GLIMEPIRIDE-4MGHypertensive heart and renal disease
Severe
How does the disease interact with Glimisave 4 Tablet:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
GLIMEPIRIDE-4MGUnspecified kidney failure
Severe
How does the disease interact with Glimisave 4 Tablet:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.

How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
GLIMEPIRIDE-4MGOther disorders of adrenal gland
Moderate
How does the disease interact with Glimisave 4 Tablet:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.

How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
GLIMEPIRIDE-4MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with Glimisave 4 Tablet:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.

How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
GLIMEPIRIDE-4MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with Glimisave 4 Tablet:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.

How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • DULOXETINE
  • DAPAGLIFLOZIN
  • GLYBURIDE
  • INSULIN
  • CANAGLIFLOZIN
  • SITAGLIPTIN
  • EMPAGLIFLOZIN
  • FUROSEMIDE
  • ATORVASTATIN
  • PREGABALIN
  • METFORMIN
  • NAPROXEN
  • CLOPIDOGREL
  • IBUPROFEN
  • WARFARIN

Disease/Condition Glossary

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and an increased chance of heart attack or stroke.

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