Dolonex 40 mg IM Injection 5 x 2 ml belongs to the group of medications known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to relieve symptoms like pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and musculoskeletal disorders. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.

Dolonex 40 mg IM Injection 5 x 2 ml contains 'Piroxicam' that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Dolonex 40 mg IM Injection 5 x 2 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as injection site reactions, diarrhoea, dizziness, nausea, vomiting, and stomach pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to speak to your doctor if you experience these side effects persistently.

Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of heart attack and the chances of stomach ulcers and bleeding. If you have had any recent heart bypass surgery, do not take Dolonex 40 mg IM Injection 5 x 2 ml unless prescribed by the doctor. Consult your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you are pregnant or breastfeeding. Dolonex 40 mg IM Injection 5 x 2 ml may cause dizziness, so drive with caution. Dolonex 40 mg IM Injection 5 x 2 ml is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Dolonex 40 mg IM Injection 5 x 2 ml as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Dolonex 40 mg IM Injection 5 x 2 ml belongs to the group of pain killers known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat musculoskeletal pain. It is also used to relieve symptoms associated with osteoarthritis, and rheumatoid arthritis, such as stiffness, swelling, and joint pain. Dolonex 40 mg IM Injection 5 x 2 ml works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

• Injection site reactions
• Diarrhoea
• Dizziness
• Nausea
• Vomiting
• Stomach pain

Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of serious heart-related problems, like heart attack and stroke. So, if you are a heart patient, let your doctor know before taking Dolonex 40 mg IM Injection 5 x 2 ml. Besides this, Dolonex 40 mg IM Injection 5 x 2 ml may also cause stomach and intestinal bleeding/ulcers, so let your doctor know if you have these problems. Do not take Dolonex 40 mg IM Injection 5 x 2 ml if you have had heart bypass surgery or coronary artery bypass graft surgery (CABG) as it can increase the risk of a heart attack. Consult your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you are pregnant or breastfeeding. Dolonex 40 mg IM Injection 5 x 2 ml may cause dizziness, so drive only if you are alert. Dolonex 40 mg IM Injection 5 x 2 ml is not recommended for children as safety has not been established. Avoid consuming alcohol along with Dolonex 40 mg IM Injection 5 x 2 ml as it could lead to increased dizziness and may increase the risk of stomach bleeding. Inform your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you have asthma, water retention (oedema) or high blood pressure, stuffy/runny nose, nasal polyps, liver or kidney problems.

Drug-Drug Interactions: Dolonex 40 mg IM Injection 5 x 2 ml may have interaction with anti-depressants (duloxetine, sertraline), anti-hypertensives (metoprolol), and drugs used to treat arthritis (celecoxib).

Drug-Food Interactions: Avoid consuming alcohol along with Dolonex 40 mg IM Injection 5 x 2 ml as it could lead to increased dizziness. It could also lead to an increase in the risk of stomach bleeding.

Drug-Disease Interactions: Inform your doctor if you have/had heart failure, fluid retention (oedema), asthma, gastrointestinal ulcer/bleeding, high blood pressure, hyperkalemia (high levels of potassium), thrombosis (formation of clots), anaemia (low red blood cells), rash, platelet aggregation inhibition, kidney and liver problems.

• DULOXETINE
• SERTRALINE
• METOPROLOL
• CELECOXIB

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Acupuncture, massage, and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
• Avoid smoking and alcohol consumption.

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age; the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons might include a past injury such as torn cartilage, dislocated joints, and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, and tendons. It can be acute or chronic, can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, muscle spasms or twitching, trouble moving the affected area, and soreness.