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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

About Dolonex 40 mg IM Injection 5 x 2 ml

Dolonex 40 mg IM Injection 5 x 2 ml belongs to the group of medications known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to relieve symptoms like pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and musculoskeletal disorders. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.

Dolonex 40 mg IM Injection 5 x 2 ml contains 'Piroxicam' that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Dolonex 40 mg IM Injection 5 x 2 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as injection site reactions, diarrhoea, dizziness, nausea, vomiting, and stomach pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to speak to your doctor if you experience these side effects persistently.

Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of heart attack and the chances of stomach ulcers and bleeding. If you have had any recent heart bypass surgery, do not take Dolonex 40 mg IM Injection 5 x 2 ml unless prescribed by the doctor. Consult your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you are pregnant or breastfeeding. Dolonex 40 mg IM Injection 5 x 2 ml may cause dizziness, so drive with caution. Dolonex 40 mg IM Injection 5 x 2 ml is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Dolonex 40 mg IM Injection 5 x 2 ml as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Composition

PIROXICAM-40MG

Manufacturer/Marketer

Pfizer Ltd

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Dolonex 40 mg IM Injection 5 x 2 ml

Musculoskeletal pain, Osteoarthritis, Rheumatoid arthritis

Medicinal Benefits

Dolonex 40 mg IM Injection 5 x 2 ml belongs to the group of pain killers known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat musculoskeletal pain. It is also used to relieve symptoms associated with osteoarthritis, and rheumatoid arthritis, such as stiffness, swelling, and joint pain. Dolonex 40 mg IM Injection 5 x 2 ml works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Side Effects of Dolonex 40 mg IM Injection 5 x 2 ml

  • Injection site reactions
  • Diarrhoea
  • Dizziness
  • Nausea
  • Vomiting
  • Stomach pain

Directions for Use

Dolonex 40 mg IM Injection 5 x 2 ml will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of serious heart-related problems, like heart attack and stroke. So, if you are a heart patient, let your doctor know before taking Dolonex 40 mg IM Injection 5 x 2 ml. Besides this, Dolonex 40 mg IM Injection 5 x 2 ml may also cause stomach and intestinal bleeding/ulcers, so let your doctor know if you have these problems. Do not take Dolonex 40 mg IM Injection 5 x 2 ml if you have had heart bypass surgery or coronary artery bypass graft surgery (CABG) as it can increase the risk of a heart attack. Consult your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you are pregnant or breastfeeding. Dolonex 40 mg IM Injection 5 x 2 ml may cause dizziness, so drive only if you are alert. Dolonex 40 mg IM Injection 5 x 2 ml is not recommended for children as safety has not been established. Avoid consuming alcohol along with Dolonex 40 mg IM Injection 5 x 2 ml as it could lead to increased dizziness and may increase the risk of stomach bleeding. Inform your doctor before taking Dolonex 40 mg IM Injection 5 x 2 ml if you have asthma, water retention (oedema) or high blood pressure, stuffy/runny nose, nasal polyps, liver or kidney problems.

Therapeutic Class

ANALGESICS

Drug-Drug Interactions

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PiroxicamKetorolac tromethamine
Critical
PiroxicamCidofovir
Critical

Drug-Drug Interactions

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PiroxicamKetorolac tromethamine
Critical
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Using ketorolac tromethamine together with Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of side effects.

How to manage the interaction:
Taking Dolonex 40 mg IM Injection 5 x 2 ml with Ketorolac tromethamine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without talking to a doctor.
PiroxicamCidofovir
Critical
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Co-administration of Cidofovir with Dolonex 40 mg IM Injection 5 x 2 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Dolonex 40 mg IM Injection 5 x 2 ml with Cidofovir is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
PiroxicamValdecoxib
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Coadministration of Dolonex 40 mg IM Injection 5 x 2 ml with Valdecoxib can increase the risk of side effects including inflammation(swelling with redness and pain), bleeding, ulceration.

How to manage the interaction:
Taking Dolonex 40 mg IM Injection 5 x 2 ml with Valdecoxib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without consulting a doctor.
PiroxicamAcalabrutinib
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Using acalabrutinib together with Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Dolonex 40 mg IM Injection 5 x 2 ml and Acalabrutinib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
PiroxicamBenazepril
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Using benazepril together with Dolonex 40 mg IM Injection 5 x 2 ml may reduce the effects of benazepril in lowering blood pressure, they may also result in kidney problems.

How to manage the interaction:
Taking Dolonex 40 mg IM Injection 5 x 2 ml with Benazepril together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not stop using any medications without a doctor's advice.
PiroxicamPonatinib
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Using Ponatinib together with Dolonex 40 mg IM Injection 5 x 2 ml may increase the risk of bleeding.

How to manage the interaction:
Taking Dolonex 40 mg IM Injection 5 x 2 ml with Ponatinib together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without consulting a doctor.
PiroxicamEtodolac
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Coadministration of Dolonex 40 mg IM Injection 5 x 2 ml with Etodolac can increase the risk of side effects such as inflammation(swelling with redness), bleeding, ulceration.

How to manage the interaction:
Although taking Etodolac and Dolonex 40 mg IM Injection 5 x 2 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
PiroxicamFlurbiprofen
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Using Dolonex 40 mg IM Injection 5 x 2 ml together with flurbiprofen may increase the risk of side effects such as inflammation(swelling with redness and pain), bleeding and ulceration.

How to manage the interaction:
Although there is a possible interaction between Flurbiprofen and Dolonex 40 mg IM Injection 5 x 2 ml, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PiroxicamLithium
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Co-administration of Dolonex 40 mg IM Injection 5 x 2 ml and Lithium can increase the levels of Lithium, which may lead to side effects.

How to manage the interaction:
Co-administration of Lithium with Dolonex 40 mg IM Injection 5 x 2 ml can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination. Do not stop using any medications without talking to a doctor.
PiroxicamTenofovir alafenamide
Severe
How does the drug interact with Dolonex 40 mg IM Injection 5 x 2 ml:
Coadministration of Dolonex 40 mg IM Injection 5 x 2 ml and Tenofovir alafenamide can increase the risk of kidney damage.

How to manage the interaction:
Although taking Tenofovir alafenamide and Dolonex 40 mg IM Injection 5 x 2 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, dizziness, and irregular heartbeat, consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DULOXETINE
  • SERTRALINE
  • METOPROLOL
  • CELECOXIB

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Author Details

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Disease/Condition Glossary

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age; the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons might include a past injury such as torn cartilage, dislocated joints, and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, and tendons. It can be acute or chronic, can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, muscle spasms or twitching, trouble moving the affected area, and soreness.

Dolonex 40 mg IM Injection 5 x 2 ml Substitute

Substitutes safety advice
  • Medicam Dt Tablet 10's

    9.45per tablet
  • Doloforce Injection 4 x 2 ml

    35.00per tablet
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