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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Composition :

PIROXICAM-20MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Dolonex IM 20 mg Injection 1 ml

Dolonex IM 20 mg Injection 1 ml belongs to the group of medications known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to relieve symptoms like pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and musculoskeletal disorders. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.

Dolonex IM 20 mg Injection 1 ml contains 'Piroxicam' that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Dolonex IM 20 mg Injection 1 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as injection site reactions, diarrhoea, dizziness, nausea, vomiting, and stomach pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to speak to your doctor if you experience these side effects persistently.

Dolonex IM 20 mg Injection 1 ml may increase the risk of heart attack and the chances of stomach ulcers and bleeding. If you have had any recent heart bypass surgery, do not take Dolonex IM 20 mg Injection 1 ml unless prescribed by the doctor. Consult your doctor before taking Dolonex IM 20 mg Injection 1 ml if you are pregnant or breastfeeding. Dolonex IM 20 mg Injection 1 ml may cause dizziness, so drive with caution. Dolonex IM 20 mg Injection 1 ml is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Dolonex IM 20 mg Injection 1 ml as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Uses of Dolonex IM 20 mg Injection 1 ml

Musculoskeletal pain, Osteoarthritis, Rheumatoid arthritis

Directions for Use

Dolonex IM 20 mg Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Dolonex IM 20 mg Injection 1 ml belongs to the group of pain killers known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat musculoskeletal pain. It is also used to relieve symptoms associated with osteoarthritis, and rheumatoid arthritis, such as stiffness, swelling, and joint pain. Dolonex IM 20 mg Injection 1 ml works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. Prostaglandins are produced at the injury site and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Dolonex IM 20 mg Injection 1 ml may increase the risk of serious heart-related problems, like heart attack and stroke. So, if you are a heart patient, let your doctor know before taking Dolonex IM 20 mg Injection 1 ml. Besides this, Dolonex IM 20 mg Injection 1 ml may also cause stomach and intestinal bleeding/ulcers, so let your doctor know if you have these problems. Do not take Dolonex IM 20 mg Injection 1 ml if you have had heart bypass surgery or coronary artery bypass graft surgery (CABG) as it can increase the risk of a heart attack. Consult your doctor before taking Dolonex IM 20 mg Injection 1 ml if you are pregnant or breastfeeding. Dolonex IM 20 mg Injection 1 ml may cause dizziness, so drive only if you are alert. Dolonex IM 20 mg Injection 1 ml is not recommended for children as safety has not been established. Avoid consuming alcohol along with Dolonex IM 20 mg Injection 1 ml as it could lead to increased dizziness and may increase the risk of stomach bleeding. Inform your doctor before taking Dolonex IM 20 mg Injection 1 ml if you have asthma, water retention (oedema) or high blood pressure, stuffy/runny nose, nasal polyps, liver or kidney problems.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Using ketorolac tromethamine together with Dolonex IM 20 mg Injection 1 ml may increase the risk of side effects.

How to manage the interaction:
Taking Dolonex IM 20 mg Injection 1 ml with Ketorolac tromethamine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Co-administration of Cidofovir with Dolonex IM 20 mg Injection 1 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Dolonex IM 20 mg Injection 1 ml with Cidofovir is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
PiroxicamDesirudin
Severe
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Taking Dolonex IM 20 mg Injection 1 ml with Desirudin together can increase the risk of bleeding.

How to manage the interaction:
Taking Dolonex IM 20 mg Injection 1 ml with Desirudin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Taking Dolonex IM 20 mg Injection 1 ml with Meloxicam together can increase the risk of side effects inflammation(swelling with redness and pain), bleeding, ulceration, and perforation.

How to manage the interaction:
There may be a possibility of interaction between Dolonex IM 20 mg Injection 1 ml and Meloxicam, but it can be taken if prescribed by a doctor. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Using panobinostat together with Dolonex IM 20 mg Injection 1 ml may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Dolonex IM 20 mg Injection 1 ml and Panobinostat, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Using acalabrutinib together with Dolonex IM 20 mg Injection 1 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Dolonex IM 20 mg Injection 1 ml and Acalabrutinib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Taking Dolonex IM 20 mg Injection 1 ml with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Fondaparinux and Dolonex IM 20 mg Injection 1 ml, you can take these medicines together if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Using regorafenib together with Dolonex IM 20 mg Injection 1 ml may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Dolonex IM 20 mg Injection 1 ml and Regorafenib, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Coadministration of Naproxen and Dolonex IM 20 mg Injection 1 ml can increase the risk or severity of stomach bleeding, inflammation(swelling with redness and pain), ulcers.

How to manage the interaction:
There may be a possible interaction between Naproxen and Dolonex IM 20 mg Injection 1 ml, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
How does the drug interact with Dolonex IM 20 mg Injection 1 ml:
Coadministration of Dolonex IM 20 mg Injection 1 ml and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although taking Ketoconazole and Dolonex IM 20 mg Injection 1 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Dolonex IM 20 mg Injection 1 ml works by blocking the effect of chemical messengers (prostaglandin), thereby reducing pain, stiffness, swelling, and inflammation.

Diarrhoea might be a side-effect of Dolonex IM 20 mg Injection 1 ml. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Do not use Dolonex IM 20 mg Injection 1 ml immediately before or after bypass surgery. Dolonex IM 20 mg Injection 1 ml may increase the risk of heart attack or stroke. Therefore, inform your doctor if you have heart problems.

Dolonex IM 20 mg Injection 1 ml may be used to treat musculoskeletal pain. Musculoskeletal pain refers to the pain in the bones, muscles, ligaments, and tendon.

Drug-Drug Interactions Checker List

  • DULOXETINE
  • SERTRALINE
  • METOPROLOL
  • CELECOXIB

Disease/Condition Glossary

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age; the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons might include a past injury such as torn cartilage, dislocated joints, and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, and tendons. It can be acute or chronic, can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, muscle spasms or twitching, trouble moving the affected area, and soreness.

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