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Reviewed By Sunny S , MBBS
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Composition

ONDANSETRON-2MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Domi Up Spray 15ml

Domi Up Spray 15ml belongs to a group of medications called ' anti-emetics' primarily used in the prevention of vomiting (being sick) and nausea (feeling sick) that usually occur after cancer chemotherapy, radiation treatment or surgery. Nausea is an uneasy feeling in which a person feels an urge to vomit while vomiting is the natural response to the body to forcefully discharge the stomach contents.

Domi Up Spray 15ml contains 'Ondanestron' that works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Domi Up Spray 15ml prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Take Domi Up Spray 15ml as prescribed. Your doctor will advise you on how often you take Domi Up Spray 15ml based on your medical condition. A person taking Domi Up Spray 15ml often experience side effects that include a feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Although, not every person faces the side effects of Domi Up Spray 15ml, and even some of the unpleasant effects of Domi Up Spray 15ml do not require medical attention.

The use of Domi Up Spray 15ml is restricted in persons who are allergic to any of the ingredients present in this medicine. Tell your doctor if you are facing liver, kidney, or heart disorders. Domi Up Spray 15ml should be used during pregnancy or breastfeeding after consulting a doctor. Domi Up Spray 15ml contains lactose so tell your doctor if you have an intolerance to some sugars.

Uses of Domi Up Spray 15ml

Nausea, Vomiting

Directions for Use

Tablet: It can be taken with or without a meal as advised by the doctor. Swallow the tablet as a whole with a glass of water. Do not break, crush or chew it. Oral disintegrating tablet/Mouth dissolving tablet (tablet MD): Check the label for directions before use. Do not handle the tablet with wet hands. Place the tablet in the mouth and allow it to dissolve. Do not swallow it as a whole.Syrup/Suspension: Shake the bottle well before use and take it as prescribed by your doctor with a measuring cup or spoon.

Medicinal Benefits

Domi Up Spray 15ml belongs to a group of medications called anti-emetics used to prevent nausea and vomiting associated with conditions like cancer chemotherapy, radiotherapy, surgery, pregnancy and motion sickness in adults and children above 4 years of age. When serotonin level increases in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Domi Up Spray 15ml acts by inhibiting the release of this serotonin, thereby preventing nausea and vomiting. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Domi Up Spray 15ml

  • Sensations of flushing
  • Constipation
  • Headache
  • Confusion
  • Dizziness
  • Fast heartbeat
  • Fever
  • Headache
  • Shortness of breath
  • Weakness

Drug Warnings

Tell your doctor if you are dealing with an uneven heart, liver problems, or any other problem. Tell your doctor if you are taking medicine for epilepsy, cancer medicines, and abnormal heartbeats. Domi Up Spray 15ml may affect a person's ability to drive. Therefore, should avoid driving or operating any machine. People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of protein phenylalanine in the blood) should not take Domi Up Spray 15ml as it may cause serious conditions. The liver patient should not take more than 8 mg of Domi Up Spray 15ml daily. Domi Up Spray 15ml should be used during pregnancy or breastfeeding after consultation with a doctor. Taking Domi Up Spray 15ml with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
OndansetronMaprotiline
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Domi Up Spray 15ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronMaprotiline
Severe
How does the drug interact with Domi Up Spray 15ml:
When Domi Up Spray 15ml is taken with maprotiline, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with maprotiline can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronTrazodone
Severe
How does the drug interact with Domi Up Spray 15ml:
Coadministration of Domi Up Spray 15ml with Trazodone may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in body).

How to manage the interaction:
Although taking Domi Up Spray 15ml along with trazodone can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
OndansetronPentazocine
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Pentazocine with Domi Up Spray 15ml may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in body).

How to manage the interaction:
Taking Domi Up Spray 15ml with Pentazocine together can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
OndansetronIvabradine
Severe
How does the drug interact with Domi Up Spray 15ml:
Coadministration of Domi Up Spray 15ml with ivabradine can increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with ivabradine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronIloperidone
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with Iloperidone increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with Iloperidone can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronClomipramine
Severe
How does the drug interact with Domi Up Spray 15ml:
The combined use of Domi Up Spray 15ml with clomipramine can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking clomipramine and Domi Up Spray 15ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronVemurafenib
Severe
How does the drug interact with Domi Up Spray 15ml:
Although it is a very rare adverse effect, taking Domi Up Spray 15ml with vemurafenib increases the risk of an abnormal heart rhythm. If you're dealing with other heart illnesses or electrolyte imbalances (for example, magnesium or potassium loss likely due to serious or prolonged diarrhoea or vomiting), you may be at greater risk.

How to manage the interaction:
Although taking Domi Up Spray 15ml along with vemurafenib can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice
OndansetronChloroquine
Severe
How does the drug interact with Domi Up Spray 15ml:
Using chloroquine together with Domi Up Spray 15ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Domi Up Spray 15ml and chloroquine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without a doctor's advice.
OndansetronEfavirenz
Severe
How does the drug interact with Domi Up Spray 15ml:
Taking Domi Up Spray 15ml with efavirenz increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Domi Up Spray 15ml along with efavirenz can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils, and low-fat dairy products will help to keep a person in good health and avoid chances of nausea and vomiting. 
  • One should avoid taking greasy or oily foods as this food triggers nausea and vomit.
  • Eat cool foods instead of hot and spicy foods.
  • Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up which has got lost due to vomiting. 

 

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Domi Up Spray 15ml Substitute

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ACETAMINOPHEN
  • TRAMADOL
  • IBUPROFEN
  • PREGABALIN
  • LORAZEPAM

Special Advise

  • Do not use Domi Up Spray 15ml with Apomorphine as it can cause a sudden fall of blood pressure leading to death or coma.
  • Domi Up Spray 15ml contains 'phenylalanine' so if you have Phenylketonuria (PKU) avoid its intake. 

Disease/Condition Glossary

Nausea/Vomiting: Nausea is an uneasy feeling in the stomach that may come and go in waves in which a person feels with a strong urge to vomit. It happens before vomiting. While vomiting is a natural response of the body in which a person wants to expel stomach contents from the mouth forcefully. It can be triggered by taste, anxiety, smell, pain, or irritation to the stomach. Usually, a person faces nausea and vomiting as the unpleasant effects of cancer therapy after chemotherapy and radiation therapy. It is essential to control vomiting and nausea in cancer patients for performing everyday activities of the day. If not controlled, it can lead to mental changes, loss of appetite, malnutrition, and dehydration.

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