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  3. Doxific Plus Injection 1's

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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Whats That

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Composition :

DOXYCYCLINE-100MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Doxific Plus Injection

Doxific Plus Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxific Plus Injection may also be used to treat or prevent anthrax.

Doxific Plus Injection contains 'Doxycycline' which stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Plus Injection helps treat bacterial infections. It is a broad-spectrum antibiotic which is effective against both gram-negative and gram-positive bacteria.

Doxific Plus Injection will be administered by a healthcare professional; do not self-administer. In some cases, Doxific Plus Injection may cause pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea. Most of these side effects of Doxific Plus Injection do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Do not take Doxific Plus Injection if you are allergic to any of the components. Consult your doctor if you are pregnant or breastfeeding. Use of Doxific Plus Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Doxific Plus Injection

Bacterial infections

Directions for Use

Doxific Plus Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Doxific Plus Injection belongs to the class of medicines called tetracycline antibiotics which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites. It is used to treat respiratory tract infections (influenza, pneumonia), genitourinary infections (syphilis, gonorrhoea), anthrax infection, sinuses, eye, and skin infections. Besides this, it is also indicated in the tick-borne infections (typhus fever) caused by the Rickettsia group of bacteria like typhus fever. Off-label, usage includes the prevention of malaria and the treatment of acne.

Storage

Keep out of sight and reach of children.

Drug Warnings

Do not take Doxific Plus Injection if you are allergic to any of its contents. Inform your doctor if you have lupus, or if you are pregnant or breastfeeding.  Use of Doxific Plus Injection during tooth development (last half of pregnancy, infancy, and in children below 8 years) may cause teeth staining (yellow-grey-brown). Consult your doctor if you experience any skin reactions, fever,  muscle, or joint problems.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Doxific Plus Injection:
Coadministration of Tretinoin with Doxific Plus Injection can increase the risk of side effects like vision problems.

How to manage the interaction:
Taking Tretinoin with Doxific Plus Injection is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Doxific Plus Injection:
Taking isotretinoin with Doxific Plus Injection may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking isotretinoin and Doxific Plus Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
DoxycyclineEtretinate
Critical
How does the drug interact with Doxific Plus Injection:
Taking Doxific Plus Injection with etretinate may increase the risk of vision problems.

How to manage the interaction:
Taking Etretinate with Doxific Plus Injection is not recommended, but can be taken if prescribed by a doctor. However, consult a doctor if you experience headache, nausea, vomiting, and visual disturbances. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Doxific Plus Injection:
Coadministration of Acitretin with Doxific Plus Injection can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Acitretin with Doxific Plus Injection together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxycyclineMipomersen
Severe
How does the drug interact with Doxific Plus Injection:
Taking Doxific Plus Injection with mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Doxific Plus Injection with Mipomersen can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineMagnesium lactate
Severe
How does the drug interact with Doxific Plus Injection:
Magnesium lactate reduces the absorption and effectiveness of Doxific Plus Injection.

How to manage the interaction:
Although taking Doxific Plus Injection with Magnesium lactate can possibly result in an interaction, they can be taken together as advised by your doctor. It is recommended to take Doxific Plus Injection 2 hours before or 6 hours after taking magnesium lactate. Do not stop using any medications without consulting a doctor.
DoxycyclineAminolevulinic acid
Severe
How does the drug interact with Doxific Plus Injection:
Co-administration of aminolevulinic acid with Doxific Plus Injection may increase the risk of sunburn.

How to manage the interaction:
Co-administration of Doxific Plus Injection with Aminolevulinic acid can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a sunburn, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Doxific Plus Injection:
Coadministration of Ketoconazole and Doxific Plus Injection may increase the risk of liver problems.

How to manage the interaction:
Although taking Doxific Plus Injection with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any symptoms such as joint pain or swelling, skin rash, itching, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DoxycyclineFerrous fumarate
Severe
How does the drug interact with Doxific Plus Injection:
Taking Doxific Plus Injection with ferrous fumarate can reduce the levels and effects of Doxific Plus Injection.

How to manage the interaction:
Although taking ferrous fumarate and Doxific Plus Injection possibly results in an interaction, they can be taken together as advised by your doctor. However, consult a doctor if you experience any unusual symptoms. Do not stop using any medications without consulting a doctor.
How does the drug interact with Doxific Plus Injection:
Coadministration of Sodium Citrate with Doxific Plus Injection can reduce the effectiveness of Doxific Plus Injection.

How to manage the interaction:
Although taking Sodium Citrate with Doxific Plus Injection can possibly result in decreased efficacy, they can be taken together if prescribed by a doctor. It is advised to separate sodium citrate and Doxific Plus Injection by three to four hours. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after completing the full course of Doxific Plus Injection to restore healthy bacteria in the intestine that may have been killed due to the usage of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Doxific Plus Injection.
  • Avoid intake of alcoholic beverages with Doxific Plus Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Doxific Plus Injection in fighting off infections.

Side Effects of Doxific Plus Injection

  • Pain, itching, swelling or redness at the site of injection
  • Nausea
  • Vomiting
  • Diarrhoea

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Doxific Plus Injection stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxific Plus Injection helps treat bacterial infections.

No, Doxific Plus Injection should not be stopped even if you feel better as it is an antibiotic medication and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form and will also become difficult to treat due to antibiotic resistance.

If you are taking Doxific Plus Injection, avoid taking antacids containing aluminium, calcium or magnesium or other drugs containing these cations; oral zinc, iron salts or bismuth preparations within 2 hours of consumption of Doxific Plus Injection as they may affect the absorption of Doxific Plus Injection. Avoid taking dairy products within 2 hours of taking Doxific Plus Injection as they may also impair the absorption of Doxific Plus Injection.

Use of Doxific Plus Injection during tooth development (last half of pregnancy, infancy, and in children below the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.

Doxific Plus Injection may make your skin sensitive to sunlight. So, apply sunscreen while going out and wear protective clothing and sunglasses. Avoid prolonged and unnecessary exposure to sunlight.

Doxific Plus Injection may lower the effectiveness of hormonal contraceptives such as birth control pills, rings, patches, or injections. Consult your doctor if you have any concerns, your doctor may advise regarding other forms of contraception.

Doxific Plus Injection does not completely prevent malaria caused by P. falciparum as Doxific Plus Injection is given as a prophylactic regimen (protection) whenever anyone enters a malaria-prone area.

Drug-Drug Interactions Checker List

  • ACITRETIN
  • ISOTRETINOIN
  • WARFARIN
  • DIGOXIN
  • PHENYTOIN
  • CARBAMAZEPINE
  • ALUMINIUM
  • CALCIUM
  • MAGNESIUM
  • BISMUTH SUBSALICYLATE

Special Advise

  • Wear sunglasses and sunscreen when you go out in the sun as Doxific Plus Injection can make your skin sensitive to light.
  • Maintain a gap of 2 hours between Doxific Plus Injection and iron supplements and antacids as taking them together might affect the working of Doxific Plus Injection.
  • Doxific Plus Injection might affect certain lab tests, inform the person doing the tests that you are taking Doxific Plus Injection.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

Have a query?

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Alcohol

Caution

It is not known if alcohol affects Doxific Plus Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Doxific Plus Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Doxific Plus Injection in pregnant women. In some cases, taking Doxific Plus Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Doxific Plus Injection.

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Breast Feeding

Caution

Doxific Plus Injection is excreted in the breast milk. However, the extent of absorption of Doxific Plus Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Doxific Plus Injection.

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Driving

Caution

It is not known if Doxific Plus Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Doxific Plus Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Doxific Plus Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Doxific Plus Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

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