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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Synonym :

DOXORUBICIN HYDROCHLORIDE

Composition :

DOXORUBICIN-10MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About DOXUTEC 10MG INJECTION 5ML

DOXUTEC 10MG INJECTION 5ML is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. DOXUTEC 10MG INJECTION 5ML is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

DOXUTEC 10MG INJECTION 5ML contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

DOXUTEC 10MG INJECTION 5ML may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer DOXUTEC 10MG INJECTION 5ML. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

DOXUTEC 10MG INJECTION 5ML should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. DOXUTEC 10MG INJECTION 5ML is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of DOXUTEC 10MG INJECTION 5ML

Breast Cancer

Directions for Use

A trained healthcare professional will administer DOXUTEC 10MG INJECTION 5ML. Hence, do not self-administer.

Medicinal Benefits

DOXUTEC 10MG INJECTION 5ML contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. DOXUTEC 10MG INJECTION 5ML is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma

Storage

Store in a cool and dry place away from sunlight
Side effects of Doxutec 10mg Injection 5ml
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.

Drug Warnings

DOXUTEC 10MG INJECTION 5ML should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. DOXUTEC 10MG INJECTION 5ML is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving DOXUTEC 10MG INJECTION 5ML without a doctor’s advice, as it can cause serious health conditions. DOXUTEC 10MG INJECTION 5ML is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
DoxorubicinEfavirenz
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Doxutec 10mg Injection 5ml:
Coadministration of Doxutec 10mg Injection 5ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Doxutec 10mg Injection 5ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinEfavirenz
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Taking Efavirenz and Doxutec 10mg Injection 5ml can increase the risk or severity of irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Doxutec 10mg Injection 5ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxorubicinAmisulpride
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Using Amisulpride together with Doxutec 10mg Injection 5ml can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Doxutec 10mg Injection 5ml and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinInfliximab
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Combining Infliximab with Doxutec 10mg Injection 5ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Doxutec 10mg Injection 5ml can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinThalidomide
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Taking thalidomide together with Doxutec 10mg Injection 5ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Doxutec 10mg Injection 5ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DoxorubicinMifepristone
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Co-administration of Doxutec 10mg Injection 5ml with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Doxutec 10mg Injection 5ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
DoxorubicinHaloperidol
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Co-administration of Doxutec 10mg Injection 5ml and Haloperidol can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Doxutec 10mg Injection 5ml with Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinMoxifloxacin
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Using Moxifloxacin together with Doxutec 10mg Injection 5ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Doxutec 10mg Injection 5ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or irregular heartbeat, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DoxorubicinNilotinib
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Coadministration of Doxutec 10mg Injection 5ml and Nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxutec 10mg Injection 5ml and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxorubicinAmiodarone
Severe
How does the drug interact with Doxutec 10mg Injection 5ml:
Coadministration of Doxutec 10mg Injection 5ml with amiodarone may increase the risk of abnormal cardiac rhythms.

How to manage the interaction:
Although taking Doxutec 10mg Injection 5ml with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor . Do not stop taking any medications without visiting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

DOXUTEC 10MG INJECTION 5ML Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

DOXUTEC 10MG INJECTION 5ML contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

DOXUTEC 10MG INJECTION 5ML can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with DOXUTEC 10MG INJECTION 5ML.

Drug-Drug Interactions Checker List

  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN
  • CLARITHROMYCIN
  • VORICONAZOLE
  • CYCLOSPORIN
  • BUPROPION
  • PAROXETINE
  • FLUOXETINE
  • DEXAMETHASONE
  • HALOPERIDOL

Special Advise

  • Avoid intercourse while on treatment with DOXUTEC 10MG INJECTION 5ML.
  • Regular complete blood count monitoring is advised.  Also, monitoring of liver function is important while receiving DOXUTEC 10MG INJECTION 5ML.
  • According to postmarketing reports, juvenile children receiving doxorubicin hydrochloride are at risk of developing late cardiovascular dysfunction. Risk factors include early age during treatment (particularly five years), large cumulative dosages, and receipt of multimodal modality therapy. All pediatric patients who have received doxorubicin hydrochloride should undergo long-term cardiovascular monitoring.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

Lymphoma: Lymphoma is a wide word for cancer that develops in lymph system cells. Hodgkin lymphoma and non-Hodgkin lymphoma (NHL) are the two most common kinds. Hodgkin lymphoma is frequently curable.

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