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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
COD available

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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Encorate 100 mg Injection 5 ml

Encorate 100 mg Injection 5 ml belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Encorate 100 mg Injection 5 ml is also used to treat bipolar disorder. Epilepsy is a central nervous system disorder characterized by a sudden rush of electrical activity in the brain leading to seizures, unusual behavior, and loss of awareness. Bipolar disorder is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 
­ 
Encorate 100 mg Injection 5 ml contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Encorate 100 mg Injection 5 ml increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
Encorate 100 mg Injection 5 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as sleepiness, dizziness, nausea, headache, and asthenia (weakness). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are of childbearing age, use effective contraception while on treatment with Encorate 100 mg Injection 5 ml. Inform your doctor before taking Encorate 100 mg Injection 5 ml if you are pregnant or breastfeeding. Do not drive or operate machinery as Encorate 100 mg Injection 5 ml may cause sleepiness and dizziness. Avoid consuming alcohol along with Encorate 100 mg Injection 5 ml as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Encorate 100 mg Injection 5 ml

Epilepsy/seizures, Bipolar disorder

Directions for Use

Encorate 100 mg Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Encorate 100 mg Injection 5 ml belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Encorate 100 mg Injection 5 ml decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Additionally, Encorate 100 mg Injection 5 ml is also used to treat bipolar disorder. Encorate 100 mg Injection 5 ml increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Encorate 100 mg Injection 5 ml

  • Somnolence (sleepiness)
  • Dizziness
  • Nausea
  • Headache
  • Asthenia (weakness)
  • Paresthesia (prickling or burning sensation)

Drug Warnings

Do not take Encorate 100 mg Injection 5 ml if you are allergic to any of its contents, if you have urea cycle problems, mitochondrial disorders, or hepatic disease/dysfunction. Inform your doctor if you have/had liver problems, porphyria (blood disorder), diabetes, immune system disorder, bleeding problems, systemic lupus erythematosus (a rare skin condition), or kidney problems. Encorate 100 mg Injection 5 ml may cause hepatotoxicity (liver damage); consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). Encorate 100 mg Injection 5 ml may also cause pancreatitis (inflammation of the pancreas); consult your doctor if you experience symptoms such as abdominal pain, vomiting, nausea, and/or anorexia (eating disorder).

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateDoripenem
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Encorate 100 mg Injection 5 ml:
Combining Sodium phenylbutyrate and Encorate 100 mg Injection 5 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Encorate 100 mg Injection 5 ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Encorate 100 mg Injection 5 ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Encorate 100 mg Injection 5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Lithium with Encorate 100 mg Injection 5 ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Encorate 100 mg Injection 5 ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Teriflunomide and Encorate 100 mg Injection 5 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Encorate 100 mg Injection 5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Vorinostat with Encorate 100 mg Injection 5 ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Encorate 100 mg Injection 5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Leflunomide and Encorate 100 mg Injection 5 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Encorate 100 mg Injection 5 ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Meropenam and Encorate 100 mg Injection 5 ml together can reduce the effect of Encorate 100 mg Injection 5 ml.

How to manage the interaction:
Co-administration of Meropenam and Encorate 100 mg Injection 5 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
The combined use of Ertapenem and Encorate 100 mg Injection 5 ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Encorate 100 mg Injection 5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Co-administration of Ketamine and Encorate 100 mg Injection 5 ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Encorate 100 mg Injection 5 ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Encorate 100 mg Injection 5 ml:
Using buprenorphine together with Encorate 100 mg Injection 5 ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Encorate 100 mg Injection 5 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Encorate 100 mg Injection 5 ml Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Encorate 100 mg Injection 5 ml decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Encorate 100 mg Injection 5 ml is used to treat bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Encorate 100 mg Injection 5 ml may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Encorate 100 mg Injection 5 ml may cause hepatotoxicity (liver damage). Consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). Serum liver tests before starting Encorate 100 mg Injection 5 ml and at regular intervals for at least six months are advised.

Encorate 100 mg Injection 5 ml should not be administered to women of child-bearing age unless it is essential to manage her condition. Women of child-bearing age must use effective contraception whilst on treatment with Encorate 100 mg Injection 5 ml.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PHENYTOIN
  • PRIMIDONE
  • CARBAMAZEPINE
  • TOPIRAMATE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • WARFARIN
  • ZIDOVUDINE
  • DIAZEPAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • RIFAMPICIN

Special Advise

  • Contact your doctor immediately if you develop suicidal thoughts such as harming or killing yourself.
  • Regular tests such as serum liver tests, platelet count, coagulation tests, and ammonia level tests are advised whilst on treatment with Encorate 100 mg Injection 5 ml.
  • If you are of childbearing age, use effective contraception during the entire treatment with Encorate 100 mg Injection 5 ml.
  • Consult your doctor immediately if you become pregnant while on treatment with Encorate 100 mg Injection 5 ml.

Disease/Condition Glossary

Epilepsy/Seizures: Seizures, also known as fits or convulsions, is a single occurrence of abnormal electrical activity in the brain, whereas epilepsy is a chronic neurological disorder characterized by recurrent seizures. The possible causes of epilepsy include traumatic brain injury, scarring on the brain after a brain injury, high fever, stroke, vascular diseases, lack of oxygen to the brain, brain tumour, and genetic disorders. Symptoms include mood changes, anxiousness, nausea, dizziness, weakness, headache, muscle jerking, spasms, loss of balance, teeth clenching, rapid blinking or eye movements, biting the tongue, confusion, and loss of consciousness.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. Symptoms of manic episodes include high energy, loss of touch with reality, and reduced need for sleep. Symptoms of depressive episodes include low motivation, low energy, and loss of interest in daily life.

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