Endoblock T Kit Combipack belongs to the class of medicines called antihypertensives, primarily used to treat pulmonary arterial hypertension (high blood pressure affecting arteries in the lungs). Pulmonary hypertension is defined as high blood pressure in the blood veins that supply the blood to the lungs (pulmonary arteries). It can affect the arteries of the lungs and the right side of the heart. The common symptoms of pulmonary hypertension are shortness of breath, dizziness, palpitations, and chest pressure.

Endoblock T Kit Combipack is a combination of two medications: ambrisentan and tadalafil. Tadalafil belongs to a class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. It aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan belongs to a class of drugs known as 'endothelin receptor antagonists.' Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

Endoblock T Kit Combipack can be taken with or without food. Swallow the tablet whole with a glass of water; do not crush, chew or break it. You are advised to take Endoblock T Kit Combipack for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Endoblock T Kit Combipack can cause side effects like headache, flushing, blocked nose, palpitations, diarrhoea, nausea, indigestion, muscle aches and pain. These side effects are unfamiliar to everyone and vary from person to person. Please get in touch with your doctor if you experience any of the side effects persistently.

If you are allergic to any of the ingredients of Endoblock T Kit Combipack, please do not take it. Stopping Endoblock T Kit Combipack without consulting your doctor may aggravate your condition and increase your chances of future cardiac problems. Consult your doctor if you are pregnant or breastfeeding. Endoblock T Kit Combipack causes drowsiness and dizziness, so drive only if you are alert. Endoblock T Kit Combipack should not be given to children as safety and effectiveness have not been established. Alcohol should not be consumed with Endoblock T Kit Combipack since it may raise the risk of low blood pressure. Keep your doctor up to date on your medical condition and medications to rule out any potential side effects.

Endoblock T Kit Combipack is an antihypertensive drug used to treat pulmonary arterial hypertension (PAH). Endoblock T Kit Combipack contains tadalafil (PDE-5 inhibitor) and ambrisentan (endothelin receptor antagonist). Tadalafil aids in treating pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs while decreasing the workload on the heart. Ambrisentan prevents endothelin, a naturally occurring substance that constricts blood vessels and raises blood pressure. It relaxes the constricted pulmonary arteries and increases blood supply to the lungs, lowering blood pressure.

• Headache
• Flushing (redness of the skin)
• Nasal and sinus congestion (blocked nose)
• Nausea
• Indigestion
• Muscle aches
• Back pain
• Pain in the extremity
• Dizziness

If you are allergic to any of the ingredients of Endoblock T Kit Combipack, please do not take it. Stopping Endoblock T Kit Combipack without consulting your doctor may aggravate your condition and increase your chances of future cardiac problems. Endoblock T Kit Combipack is not recommended during pregnancy because it is harmful to the foetus. Before using Endoblock T Kit Combipack, you should definitely get a negative pregnancy test. Also, if you are undergoing treatment with Endoblock T Kit Combipack, please use reliable forms of birth control to avoid pregnancy. Brief your medical history to the doctor if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure). Endoblock T Kit Combipack causes drowsiness and dizziness, so drive if you are alert. Avoid consuming alcohol with Endoblock T Kit Combipack as it may raise the chance of developing low blood pressure. Endoblock T Kit Combipack is not suggested for patients under the age of 18.

Drug-Drug Interactions: Endoblock T Kit Combipack may interact with other medicines used to treat PAH (e.g. iloprost, epoprostenol), medicines categorised as nitrates (e.g. organic nitrate), alpha-blockers (e.g. tamsulosin), antihypertensive medications (e.g. amlodipine, enalapril and metoprolol), antifungals (e.g. itraconazole), antibiotics (e.g. rifampicin) and immunosuppressants (e.g. cyclosporine).

Drug-Food Interactions: Limit or avoid the intake of alcohol.

Drug-Disease Interactions: Endoblock T Kit Combipack may interact with diseases conditions, including heart disorders, liver or kidney illnesses, lung conditions, anaemia, oedema (fluid retention), seizures, eye disorders, low blood pressure and severe dehydration.

• ILOPROST
• EPOPROSTENOL
• ORGANIC NITRATE
• TAMSULOSIN
• AMLODIPINE
• ENALAPRIL
• METOPROLOL
• ITRACONAZOLE
• RIFAMPICIN
• CYCLOSPORINE

• Keep your heart healthy by exercising on a regular basis.
• Consume natural and nutritious foods while avoiding high-sodium processed foods.
• Reduce your salt intake in your diet to keep your blood pressure stable.
• Obesity is a risk factor for hypertension, so reduce those excess pounds.
• Avoid smoking and drinking alcohol.
• High blood pressure can also be caused by chronic stress. As a result, avoid stress and make time for yourself to relax and engage in things that you enjoy.
• Include heart-healthy omega 3 fatty acid-containing foods and beverages in your daily diet.
• To lower your blood pressure (BP), you can also use low-fat cooking oils such as olive oil, coconut oil, soybean oil and canola oil.

• Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor.
• Your doctor may suggest liver function tests since Endoblock T Kit Combipack may cause a change in liver enzymes.

Pulmonary Arterial Hypertension: It is referred to as high blood pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries). It can affect the arteries of the lungs and the right side of the heart. The walls of the pulmonary arteries thicken and stiffen, making it difficult for blood to flow through. Because of the reduced blood flow, the right side of the heart has a harder time pumping blood through the arteries. The common symptoms of pulmonary hypertension are shortness of breath, dizziness, palpitations, and chest pressure. It can affect people of all ages, but it's more common in people who already have a heart or lung problem.