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Written By Veda Maddala , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

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Composition :

LEUPRORELIN-3.75MG

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Endorelin Depot 3.75Mg Inj

Endorelin Depot 3.75Mg Inj belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, Endorelin Depot 3.75Mg Inj is used to treat premature puberty in children. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems.

Endorelin Depot 3.75Mg Inj contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Endorelin Depot 3.75Mg Inj is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.  

Use Endorelin Depot 3.75Mg Inj as prescribed by your doctor. You are advised to take Endorelin Depot 3.75Mg Inj for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. Most of these side effects of Endorelin Depot 3.75Mg Inj do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Endorelin Depot 3.75Mg Inj or any other medicines, please tell your doctor. Endorelin Depot 3.75Mg Inj is contraindicated in pregnant and breastfeeding women. It is advised to use effective contraceptive measures to avoid pregnancy while taking Endorelin Depot 3.75Mg Inj as it may cause birth defects. Endorelin Depot 3.75Mg Inj should be used with caution in children. You are recommended to avoid or limit consumption of alcohol with Endorelin Depot 3.75Mg Inj as it may increase the risk of bone density loss. Drive only if you are alert as Endorelin Depot 3.75Mg Inj may cause dizziness, drowsiness, or vision disturbances.

Uses of Endorelin Depot 3.75Mg Inj

Prostate cancer, Breast cancer, Endometriosis, Premature puberty

Directions for Use

Endorelin Depot 3.75Mg Inj will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Endorelin Depot 3.75Mg Inj contains Leuprorelin which works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and oestrogen in women. Thereby, Endorelin Depot 3.75Mg Inj is used in the treatment of prostate cancer by inhibiting the growth of the tumour or causing it to shrink.  Also, Endorelin Depot 3.75Mg Inj is used to treat hormone-responsive breast cancer in pre and postmenopausal women. By reducing testosterone and oestrogen levels, Endorelin Depot 3.75Mg Inj delays the onset of puberty in children.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Endorelin Depot 3.75Mg Inj

In men:

  • Muscle weakness
  • Bone pain
  • Inability to have an erection
  • Tiredness
  • Decreased interest in sex

In women:

  • Breast tenderness
  • Difficulty in sleeping
  • Headache
  • Vaginal dryness
  • Changes in breast size

In children:

  • Acne
  • Mood swings
  • Vaginal bleeding
  • Pain, redness, swelling or skin hardening at the injection site

Drug Warnings

If you are allergic to Endorelin Depot 3.75Mg Inj or any other medicines, please tell your doctor. Endorelin Depot 3.75Mg Inj is contraindicated in pregnant and breastfeeding women. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Endorelin Depot 3.75Mg Inj as it may cause birth defects. Endorelin Depot 3.75Mg Inj should be used with caution in children. You are advised to quit smoking as it may increase the risk of prostate cancer. You are recommended to avoid or limit consumption of alcohol with Endorelin Depot 3.75Mg Inj as it may increase the risk of bone density loss. Drive only if you are alert as Endorelin Depot 3.75Mg Inj may cause dizziness, drowsiness or vision disturbances.

Drug-Drug Interactions

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LeuprorelinCisapride
Critical
LeuprorelinSaquinavir
Critical

Drug-Drug Interactions

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LeuprorelinCisapride
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Endorelin Depot 3.75Mg Inj with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking Endorelin Depot 3.75Mg Inj with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCitalopram
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Coadministration of Endorelin Depot 3.75Mg Inj and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinNilotinib
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinPimozide
Critical
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking Endorelin Depot 3.75Mg Inj with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Endorelin Depot 3.75Mg Inj with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCeritinib
Severe
How does the drug interact with Endorelin Depot 3.75Mg Inj:
Taking Endorelin Depot 3.75Mg Inj and Ceritinib together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Endorelin Depot 3.75Mg Inj and Ceritinib, you can take these medicines together if prescribed by your doctor. If you experience symptoms like irregular heart rhythm, dizziness, fainting, or difficulty breathing, you must contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, and saturated fat found in animal products, milk, and dairy products as they may increase the risk of prostate cancer.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Quit smoking to reduce the risk of prostate cancer.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.

Habit Forming

No

Therapeutic Class

GONADOTROPHIN-RELEASING HORMONE AGONIST

Endorelin Depot 3.75Mg Inj Substitute

Substitutes safety advice
  • Luprova 3.75 Injection 1's

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  • Palutor 3.75 mg Combipack Injection 1's

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Endorelin Depot 3.75Mg Inj contains Leuprorelin, a synthetic hormone that works similar to the natural hormone, gonadotropin-releasing hormone (GnRH) by acting on the pituitary gland and decreases the levels of testosterone in men and oestrogen in women. Thereby, Endorelin Depot 3.75Mg Inj is used in the treatment of prostate cancer by inhibiting the growth of tumour or causing it to shrink.

Endorelin Depot 3.75Mg Inj may stop menstrual periods. However, after 7 to 12 weeks of taking the final dose of injection, periods will resume. Please consult a doctor if you have any concerns regarding this.

Endorelin Depot 3.75Mg Inj should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Endorelin Depot 3.75Mg Inj and inform your doctor if you have diabetes before taking Endorelin Depot 3.75Mg Inj.

Endorelin Depot 3.75Mg Inj may be used to treat endometriosis (tissue lining the uterus known as endometrium grows outside the uterus). Endorelin Depot 3.75Mg Inj reduces oestrogen levels and causes menopause temporarily. Thereby, shrink the tissue outside the uterus or stop its growth.

Endorelin Depot 3.75Mg Inj may decrease bone density, especially when used for the treatment of premature puberty in children. Therefore, regular monitoring of bone density is recommended while taking Endorelin Depot 3.75Mg Inj.

Endorelin Depot 3.75Mg Inj should be used with extreme caution in patients suffering from depression as it may worsen the condition. Therefore, inform your doctor if you have any history of depression before taking Endorelin Depot 3.75Mg Inj.

Drug-Drug Interactions Checker List

  • MOXIFLOXACIN
  • PROCAINAMIDE
  • QUINIDINE
  • SOTALOL
  • AMIODARONE
  • METHADONE
  • CLOZAPINE

Special Advise

Endorelin Depot 3.75Mg Inj may cause changes in blood cholesterol levels or affect values in liver functioning tests. Therefore, inform your doctor that you are taking Endorelin Depot 3.75Mg Inj before undergoing any tests.

Disease/Condition Glossary

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems. Certain factors increase the risk of prostate cancer, such as the family history of prostate cancer, older age, obesity, or genetic changes.

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast.

Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements.  

Premature puberty: It is a condition in which the signs of puberty (physical changes in which a child’s body matures into an adult body) start early in children, i.e., before 9 years in girls and before 10 years in boys.

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