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Written By Veda Maddala , M Pharmacy
Reviewed By Hari Kumar , MBBS

About Luprovian 3.75 mg Injection Combipack

Luprovian 3.75 mg Injection Combipack belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, Luprovian 3.75 mg Injection Combipack is used to treat premature puberty in children. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems.

Luprovian 3.75 mg Injection Combipack contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.  

Use Luprovian 3.75 mg Injection Combipack as prescribed by your doctor. You are advised to take Luprovian 3.75 mg Injection Combipack for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. Most of these side effects of Luprovian 3.75 mg Injection Combipack do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Luprovian 3.75 mg Injection Combipack or any other medicines, please tell your doctor. Luprovian 3.75 mg Injection Combipack is contraindicated in pregnant and breastfeeding women. It is advised to use effective contraceptive measures to avoid pregnancy while taking Luprovian 3.75 mg Injection Combipack as it may cause birth defects. Luprovian 3.75 mg Injection Combipack should be used with caution in children. You are recommended to avoid or limit consumption of alcohol with Luprovian 3.75 mg Injection Combipack as it may increase the risk of bone density loss. Drive only if you are alert as Luprovian 3.75 mg Injection Combipack may cause dizziness, drowsiness, or vision disturbances.

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Non returnable*
COD available

Online payment accepted

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Sep-2024

for this medicine

Uses of Luprovian 3.75 mg Injection Combipack

Prostate cancer, Breast cancer, Endometriosis, Premature puberty

Medicinal Benefits

Luprovian 3.75 mg Injection Combipack contains Leuprorelin which works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and oestrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of the tumour or causing it to shrink.  Also, Luprovian 3.75 mg Injection Combipack is used to treat hormone-responsive breast cancer in pre and postmenopausal women. By reducing testosterone and oestrogen levels, Luprovian 3.75 mg Injection Combipack delays the onset of puberty in children.

Side Effects of Luprovian 3.75 mg Injection Combipack

In men:

  • Muscle weakness
  • Bone pain
  • Inability to have an erection
  • Tiredness
  • Decreased interest in sex

In women:

  • Breast tenderness
  • Difficulty in sleeping
  • Headache
  • Vaginal dryness
  • Changes in breast size

In children:

  • Acne
  • Mood swings
  • Vaginal bleeding
  • Pain, redness, swelling or skin hardening at the injection site

Directions for Use

Luprovian 3.75 mg Injection Combipack will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Luprovian 3.75 mg Injection Combipack or any other medicines, please tell your doctor. Luprovian 3.75 mg Injection Combipack is contraindicated in pregnant and breastfeeding women. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Luprovian 3.75 mg Injection Combipack as it may cause birth defects. Luprovian 3.75 mg Injection Combipack should be used with caution in children. You are advised to quit smoking as it may increase the risk of prostate cancer. You are recommended to avoid or limit consumption of alcohol with Luprovian 3.75 mg Injection Combipack as it may increase the risk of bone density loss. Drive only if you are alert as Luprovian 3.75 mg Injection Combipack may cause dizziness, drowsiness or vision disturbances.

Therapeutic Class

GONADOTROPHIN-RELEASING HORMONE AGONIST

Drug-Drug Interactions

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LeuprorelinPimozide
Critical
LeuprorelinVandetanib
Critical

Drug-Drug Interactions

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LeuprorelinPimozide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Luprovian 3.75 mg Injection Combipack with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Luprovian 3.75 mg Injection Combipack with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCitalopram
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Coadministration of Luprovian 3.75 mg Injection Combipack and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinNilotinib
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinCisapride
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Luprovian 3.75 mg Injection Combipack with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinProcainamide
Severe
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with procainamide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Luprovian 3.75 mg Injection Combipack and procainamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • MOXIFLOXACIN
  • PROCAINAMIDE
  • QUINIDINE
  • SOTALOL
  • AMIODARONE
  • METHADONE
  • CLOZAPINE

Diet & Lifestyle Advise

  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, and saturated fat found in animal products, milk, and dairy products as they may increase the risk of prostate cancer.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Quit smoking to reduce the risk of prostate cancer.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.

Habit Forming

No

Special Advise

Luprovian 3.75 mg Injection Combipack may cause changes in blood cholesterol levels or affect values in liver functioning tests. Therefore, inform your doctor that you are taking Luprovian 3.75 mg Injection Combipack before undergoing any tests.

Author Details

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Disease/Condition Glossary

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems. Certain factors increase the risk of prostate cancer, such as the family history of prostate cancer, older age, obesity, or genetic changes.

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast.

Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements.  

Premature puberty: It is a condition in which the signs of puberty (physical changes in which a child’s body matures into an adult body) start early in children, i.e., before 9 years in girls and before 10 years in boys.

Luprovian 3.75 mg Injection Combipack Substitute

Substitutes safety advice
  • Luprova 3.75Mg Inj

    by AYUR

    2858.50per tablet
  • Endorelin Depot 3.75Mg Inj

    by AYUR

    2505.90per tablet
  • Leuprolide Depot 3.75mg Injection 1's

    3234.49per tablet
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