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Written By Veda Maddala , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

NORETHISTERONE-5MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Endotif Tablet

Endotif Tablet belongs to the class of medicines called progestogens used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, Endotif Tablet may be used in the treatment of breast cancer. Endometriosis is a disorder in which the uterus's tissue lining (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain.

Endotif Tablet contains Norethisterone that works by mimicking the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

Take Endotif Tablet as prescribed by your doctor. You are advised to take Endotif Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, diarrhea, headache, breast pain, and tenderness. Most of these side effects of Endotif Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Endotif Tablet or any other medicines, please tell your doctor. Endotif Tablet is not recommended for pregnant women as it may harm the unborn baby. If you are breastfeeding, consult a doctor before taking Endotif Tablet. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Endotif Tablet. You are advised to stop smoking while taking Endotif Tablet as it may increase the risk of adverse effects.

Uses of Endotif Tablet

Heavy, painful or irregular periods, Premenstrual syndrome (PMS), Endometriosis, Breast cancer

Directions for Use

Take Endotif Tablet with or without food as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Endotif Tablet contains Norethisterone, a synthetic hormone that mimics the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

Storage

Keep Endotif Tablet out of reach and sight of children.

Drug Warnings

If you are allergic to Endotif Tablet or any other medicines, please tell your doctor. Endotif Tablet is not recommended for pregnant women as it may harm an unborn baby. If you are breastfeeding, consult a doctor before taking Endotif Tablet. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Endotif Tablet. You are advised to stop smoking while taking Endotif Tablet as it may increase the risk of adverse effects. If you are about to undergo any surgery, please inform your doctor that you are taking Endotif Tablet as it may increase the effect of certain anesthetics. If you experience sudden shortness of breath, rapid heartbeat, sudden, severe, sharp pain in the chest, or cough up blood, stop taking Endotif Tablet and consult a doctor immediately as these might be signs of a blood clot in the lungs.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Endotif Tablet:
Coadministration of Endotif Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Endotif Tablet in the body.

How to manage the interaction:
Taking Endotif Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Endotif Tablet:
Coadministration of Endotif Tablet with Oxcarbazepine can reduce the blood levels and effects of norethindrone. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking oxcarbazepine and Endotif Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endotif Tablet:
Eslicarbazepine may reduce the effects of Endotif Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Endotif Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
NorethisteroneRifapentine
Severe
How does the drug interact with Endotif Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Endotif Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Endotif Tablet:
Using Felbamate and Endotif Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Endotif Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endotif Tablet:
Using tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking Endotif Tablet with tranexamic acid can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endotif Tablet:
Taking Endotif Tablet with rifampicin can decrease the blood levels of Endotif Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Endotif Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneEtretinate
Severe
How does the drug interact with Endotif Tablet:
Using Etretinate and Endotif Tablet together can cause severe, birth defects. Never use etretinate if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy.

How to manage the interaction:
Although taking Endotif Tablet and Etretinate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, make sure to contact your doctor right away. These symptoms may be related to your birth control. Do not stop using any medications without a doctor's advice.
How does the drug interact with Endotif Tablet:
Taking carbamazepine and Endotif Tablet may possibly reduce the effects of Endotif Tablet which may result in higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking carbamazepine and Endotif Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. Contact your doctor if you experience hot flashes, vaginal dryness, or uncontrolled bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endotif Tablet:
Coadministration of Endotif Tablet with Topiramate can reduce the blood levels and effects of norethindrone in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Endotif Tablet and topiramate together can result in an interaction; it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, hot flashes or vaginal dryness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Endotif Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Endotif Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Endotif Tablet dose.

Diet & Lifestyle Advise

  • Avoid fried and processed foods.
  • Include fiber-rich foods like whole grains, fruits, and vegetables in your diet.
  • Avoid refined carbohydrates that are high in sugars.
  • Replace animal proteins (like eggs, fish, and meat) with vegetable protein sources (nuts, seeds, and beans).
  • Avoid drinking excess alcohol or caffeinated drinks as they can worsen the symptoms.
  • Maintain a healthy weight, do moderate exercise regularly.
  • Avoid smoking and alcohol intake.

Side Effects of Endotif Tablet

  • Unusual vaginal bleeding or spotting
  • Dizziness
  • Dry mouth
  • Constipation
  • Abdominal pain/cramps
  • Nausea
  • Diarrhea
  • Headache
  • Breast pain and tenderness

Habit Forming

No

Therapeutic Class

PROGESTIN

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Endotif Tablet contains Norethisterone, a synthetic hormone that works by mimicking the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

Endotif Tablet may be used to delay periods. Endotif Tablet keeps progesterone levels high and prevents shedding of the womb lining. However, please consult a doctor before using Endotif Tablet.

Endotif Tablet may increase the risk of a blood clot in the veins of the leg, especially if you are overweight, smoking, or have a history of a blood clot in the lungs or veins, repeated miscarriage or have major surgery, serious injury, or systemic lupus erythematosus (autoimmune disease). Therefore, please inform your doctor if you have any of these conditions before taking Endotif Tablet.

You are not recommended to take Endotif Tablet with rifampicin as it may decrease the levels of Endotif Tablet in blood and reduce its effectiveness. However, please consult a doctor before taking Endotif Tablet with other medicines.

Periods usually resume within 3 days of discontinuing Endotif Tablet. However, please consult a doctor if you have any concerns regarding this.

Endotif Tablet may cause changes in blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Endotif Tablet and inform your doctor if you have diabetes before taking Endotif Tablet.

Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • PHENYTOIN
  • NELFINAVIR
  • RITONAVIR
  • AMINOGLUTETHIMIDE
  • COTRIMOXAZOLE
  • RIFAMPICIN
  • TETRACYCLINE
  • CICLOSPORIN

Special Advise

  • Endotif Tablet may interfere with certain laboratory tests. Therefore, inform your doctor that you are taking Endotif Tablet before undergoing any tests.

Disease/Condition Glossary

Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements. 

Have a query?

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Alcohol

Caution

The interaction of Endotif Tablet with alcohol is unknown. Please consult a doctor before consuming alcohol while using Endotif Tablet.

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Pregnancy

Unsafe

Endotif Tablet is a category X pregnancy drug and is not recommended for use during pregnancy as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Endotif Tablet is given to breastfeeding women only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Safe if prescribed

Endotif Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Unsafe

Endotif Tablet is not recommended if you have liver disease. However, if you have any concerns regarding this, please consult a doctor.

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Kidney

Caution

Take Endotif Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Endotif Tablet is not recommended for use in children under 18 years.

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