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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer

Zydus Healthcare Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Endoxan Tablet

Endoxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Endoxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.
 
You are advised to take Endoxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Endoxan Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Endoxan Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Endoxan Tablet

Cancer, nephrotic syndrome (kidney disease)

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew it.Oral liquid: Check the label for directions before use and take the prescribed dose using the dosing syringe or medicine spoon.

Medicinal Benefits

Endoxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Endoxan Tablet

  • Fever
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hair loss
  • Low blood cell count
  • Abdominal pain

Drug Warnings

Do not take Endoxan Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
CyclophosphamideCidofovir
Critical

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
How does the drug interact with Endoxan Tablet:
Co-administration of Nalidixic acid with Endoxan Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Endoxan Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideCidofovir
Critical
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideThiotepa
Severe
How does the drug interact with Endoxan Tablet:
When Thiotepa is taken with Endoxan Tablet, can increase the blood levels or add to the medication side effects of Endoxan Tablet.

How to manage the interaction:
Although taking Thiotepa and Endoxan Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLidocaine
Severe
How does the drug interact with Endoxan Tablet:
Taking Lidocaine with Endoxan Tablet may increase the risk of methemoglobinemia (a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with lidocaine if prescribed by the doctor. However, consult the doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue the medication without consulting a doctor.
CyclophosphamideBusulfan
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Endoxan Tablet, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Endoxan Tablet:
Taking Endoxan Tablet with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Ropivacaine with Endoxan Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Endoxan Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Endoxan Tablet may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Endoxan Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Endoxan Tablet and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Endoxan Tablet Substitute

Substitutes safety advice
  • Cycloxan Tablet 10's

    by Others

    3.66per tablet
  • Adcyclo 50 Tablet 10's

    by Others

    3.51per tablet
  • Endoxan Tablet 10's

    by Others

    3.83per tablet
  • Finoxamide Tablet 10's

    by Others

    2.97per tablet
  • Eldamide 50mg Tablet

    by Others

    2.03per tablet

Author Details

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Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Endoxan Tablet treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Endoxan Tablet if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Endoxan Tablet. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

Drug-Drug Interactions Checker List

  • DOXORUBICIN
  • PACLITAXEL
  • APREPITANT
  • ONDANSETRON
  • ZIDOVUDINE

Special Advise

  • Monitoring of complete blood count while taking Endoxan Tablet is advised.
  • Drink plenty of fluids to prevent urinary problems.
  • If you are due to have any surgery, inform the doctor that you are taking Endoxan Tablet .

Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner, leading to tumour formation. Tumours could be benign/non-cancerous or malignant/cancerous. Lymphoma is a cancer of the lymphatic system, which is the body’s disease-fighting system. It includes lymph nodes, spleen, bone marrow, and thymus. Symptoms include enlarged lymph nodes, weight loss, and fatigue. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy, and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder with symptoms such as protein in the urine, high cholesterol levels, low blood protein levels, high triglyceride levels, and swelling.

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