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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS

About Endoxan Tablet 10's

Endoxan Tablet 10's belongs to the group of anti-cancer medicines used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Endoxan Tablet 10's is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Endoxan Tablet 10's contains ‘Cyclophosphamide’, an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet 10's helps to treat cancer by killing the cancer cells.
 
You are advised to take Endoxan Tablet 10's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Endoxan Tablet 10's if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Endoxan Tablet 10's if you are pregnant or breastfeeding. Endoxan Tablet 10's may cause dizziness, so drive only if you are alert. Endoxan Tablet 10's should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Zydus Healthcare Ltd

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Endoxan Tablet 10's

Cancer, nephrotic syndrome (kidney disease)

Medicinal Benefits

Endoxan Tablet 10's belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Endoxan Tablet 10's is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan Tablet 10's is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet 10's helps to treat cancer by killing the cancer cells.

Side Effects of Endoxan Tablet 10's

  • Fever
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hair loss
  • Low blood cell count
  • Abdominal pain

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew it.Oral liquid: Check the label for directions before use and take the prescribed dose using the dosing syringe or medicine spoon.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Endoxan Tablet 10's if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Endoxan Tablet 10's if you are pregnant or breastfeeding. Endoxan Tablet 10's may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Endoxan Tablet 10's and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Nalidixic acid with Endoxan Tablet 10's may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Endoxan Tablet 10's and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideFingolimod
Severe
How does the drug interact with Endoxan Tablet 10's:
Taking Fingolimod's ability to suppress the immune system may be enhanced by Endoxan Tablet 10's.

How to manage the interaction:
Although taking Endoxan Tablet 10's and Fingolimod together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away - a serious infection, problems, high body temperature, feeling cold, loose stools, a painful throat, body discomfort, difficulty breathing, losing weight, or experiencing pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.
CyclophosphamideBaricitinib
Severe
How does the drug interact with Endoxan Tablet 10's:
Using baricitinib together with Endoxan Tablet 10's may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Endoxan Tablet 10's if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue the medication without consulting a doctor.
CyclophosphamideLeflunomide
Severe
How does the drug interact with Endoxan Tablet 10's:
Taking Endoxan Tablet 10's with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet 10's can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideClozapine
Severe
How does the drug interact with Endoxan Tablet 10's:
Taking Clozapine and Endoxan Tablet 10's may increase the risk of infection.

How to manage the interaction:
Taking Endoxan Tablet 10's with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideDeferiprone
Severe
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Endoxan Tablet 10's and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of Endoxan Tablet 10's with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Endoxan Tablet 10's with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Endoxan Tablet 10's can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideGolimumab
Severe
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Golimumab with Endoxan Tablet 10's may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Endoxan Tablet 10's with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Endoxan Tablet 10's:
Co-administration of Endoxan Tablet 10's with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Endoxan Tablet 10's and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Endoxan Tablet 10's:
Endoxan Tablet 10's usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Endoxan Tablet 10's treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Endoxan Tablet 10's if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Endoxan Tablet 10's. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet 10's:
Endoxan Tablet 10's should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet 10's treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet 10's should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet 10's:
Endoxan Tablet 10's should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet 10's treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet 10's should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet 10's:
Endoxan Tablet 10's should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet 10's treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet 10's should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

Drug-Drug Interactions Checker List

  • DOXORUBICIN
  • PACLITAXEL
  • APREPITANT
  • ONDANSETRON
  • ZIDOVUDINE

Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Special Advise

  • Monitoring of complete blood count while taking Endoxan Tablet 10's is advised.
  • Drink plenty of fluids to prevent urinary problems.
  • If you are due to have any surgery, inform the doctor that you are taking Endoxan Tablet 10's.

Author Details

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Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner, leading to tumour formation. Tumours could be benign/non-cancerous or malignant/cancerous. Lymphoma is a cancer of the lymphatic system, which is the body’s disease-fighting system. It includes lymph nodes, spleen, bone marrow, and thymus. Symptoms include enlarged lymph nodes, weight loss, and fatigue. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy, and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder with symptoms such as protein in the urine, high cholesterol levels, low blood protein levels, high triglyceride levels, and swelling.

Endoxan Tablet 10's Substitute

Substitutes safety advice
  • Cycloxan Tablet 10's

    3.47per tablet
  • Adcyclo 50 Tablet 10's

    3.51per tablet
  • Endoxan Tablet 10's

    3.83per tablet
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