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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About ENDOXAN N INJECTION 1GM

ENDOXAN N INJECTION 1GM belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, ENDOXAN N INJECTION 1GM is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
ENDOXAN N INJECTION 1GM contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, ENDOXAN N INJECTION 1GM helps treat cancer. ENDOXAN N INJECTION 1GM suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, ENDOXAN N INJECTION 1GM may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. ENDOXAN N INJECTION 1GM may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of ENDOXAN N INJECTION 1GM

Malignant diseases (cancer), nephrotic syndrome (kidney disease)

Medicinal Benefits

ENDOXAN N INJECTION 1GM belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. ENDOXAN N INJECTION 1GM works by stopping or slowing the growth of cancer cells in the body. Thereby, ENDOXAN N INJECTION 1GM helps treat cancer. Additionally, ENDOXAN N INJECTION 1GM is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. ENDOXAN N INJECTION 1GM suppresses the body's immune system, thereby helping treat nephrotic syndrome.

Side Effects of ENDOXAN N INJECTION 1GM

  • Nausea
  • Vomiting
  • Stomatitis (inflamed and sore mouth)
  • Weakness
  • Malaise (general discomfort)
  • Fever
  • Leukopenia (low white blood cell count)
  • Alopecia (hair loss)

Directions for Use

ENDOXAN N INJECTION 1GM will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take ENDOXAN N INJECTION 1GM if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. ENDOXAN N INJECTION 1GM may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of ENDOXAN N INJECTION 1GM and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of Nalidixic acid with ENDOXAN N INJECTION 1GM may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of ENDOXAN N INJECTION 1GM and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideFingolimod
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Taking Fingolimod's ability to suppress the immune system may be enhanced by ENDOXAN N INJECTION 1GM.

How to manage the interaction:
Although taking ENDOXAN N INJECTION 1GM and Fingolimod together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away - a serious infection, problems, high body temperature, feeling cold, loose stools, a painful throat, body discomfort, difficulty breathing, losing weight, or experiencing pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.
CyclophosphamideBaricitinib
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Using baricitinib together with ENDOXAN N INJECTION 1GM may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with ENDOXAN N INJECTION 1GM if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue the medication without consulting a doctor.
CyclophosphamideLeflunomide
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Taking ENDOXAN N INJECTION 1GM with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, ENDOXAN N INJECTION 1GM can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideClozapine
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Taking Clozapine and ENDOXAN N INJECTION 1GM may increase the risk of infection.

How to manage the interaction:
Taking ENDOXAN N INJECTION 1GM with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideDeferiprone
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of ENDOXAN N INJECTION 1GM and Deferiprone may increase the risk of serious and potential infections.

How to manage the interaction:
Co-administration of ENDOXAN N INJECTION 1GM with Deferiprone can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of ENDOXAN N INJECTION 1GM with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with ENDOXAN N INJECTION 1GM can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideGolimumab
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of Golimumab with ENDOXAN N INJECTION 1GM may increase the risk of serious infections.

How to manage the interaction:
Co-administration of ENDOXAN N INJECTION 1GM with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideVoclosporin
Severe
How does the drug interact with ENDOXAN N INJECTION 1GM:
Co-administration of ENDOXAN N INJECTION 1GM with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between ENDOXAN N INJECTION 1GM and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with ENDOXAN N INJECTION 1GM:
ENDOXAN N INJECTION 1GM usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During ENDOXAN N INJECTION 1GM treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given ENDOXAN N INJECTION 1GM if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with ENDOXAN N INJECTION 1GM. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with ENDOXAN N INJECTION 1GM:
ENDOXAN N INJECTION 1GM should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During ENDOXAN N INJECTION 1GM treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with ENDOXAN N INJECTION 1GM should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with ENDOXAN N INJECTION 1GM:
ENDOXAN N INJECTION 1GM should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During ENDOXAN N INJECTION 1GM treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with ENDOXAN N INJECTION 1GM should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with ENDOXAN N INJECTION 1GM:
ENDOXAN N INJECTION 1GM should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During ENDOXAN N INJECTION 1GM treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with ENDOXAN N INJECTION 1GM should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

Drug-Drug Interactions Checker List

  • NATALIZUMAB
  • PACLITAXEL
  • ZIDOVUDINE
  • AMIODARONE
  • AMPHOTERICIN B
  • INDOMETHACIN
  • AZATHIOPRINE
  • BUSULFAN

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Special Advise

  • Monitoring of complete blood count whilst on treatment with ENDOXAN N INJECTION 1GM is advised.
  • Women of childbearing potential must use highly effective contraception during treatment and for up to 1 year after the last dose.
  • Male patients who are sexually active with a female partner of child-bearing potential must use condoms during treatment and for up to 6 months after the last dose.

Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner leading to the formation of tumours. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder in which the body excretes too much protein in the urine. Symptoms include foamy urine, weight gain, and swelling around the eyes and in the ankles and feet.

ENDOXAN N INJECTION 1GM Substitute

Substitutes safety advice
  • Phosmid 1000 mg Injection 1's

    73.80per tablet
  • Phoxelon 1000mg Injection 1's

    123.80per tablet
  • Uniphos 1000 Injection 1's

    126.90per tablet
  • Cyphos 1000 mg Injection 1's

    120.60per tablet
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