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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Uniphos 1000 Injection

Uniphos 1000 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, Uniphos 1000 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Uniphos 1000 Injection contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Uniphos 1000 Injection suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, Uniphos 1000 Injection may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. Uniphos 1000 Injection may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Uniphos 1000 Injection

Malignant diseases (cancer), nephrotic syndrome (kidney disease)

Directions for Use

Uniphos 1000 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Uniphos 1000 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Uniphos 1000 Injection works by stopping or slowing the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Additionally, Uniphos 1000 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. Uniphos 1000 Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Uniphos 1000 Injection

  • Nausea
  • Vomiting
  • Stomatitis (inflamed and sore mouth)
  • Weakness
  • Malaise (general discomfort)
  • Fever
  • Leukopenia (low white blood cell count)
  • Alopecia (hair loss)

Drug Warnings

Do not take Uniphos 1000 Injection if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. Uniphos 1000 Injection may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Uniphos 1000 Injection and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Nalidixic acid with Uniphos 1000 Injection may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Uniphos 1000 Injection and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideTenofovir disoproxil
Severe
How does the drug interact with Uniphos 1000 Injection:
Coadministration of Tenofovir disoproxil with Uniphos 1000 Injection may increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction, Uniphos 1000 Injection can be taken with Tenofovir disoproxil if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medication without consulting a doctor.
CyclophosphamideClozapine
Severe
How does the drug interact with Uniphos 1000 Injection:
Taking Clozapine and Uniphos 1000 Injection may increase the risk of infection.

How to manage the interaction:
Taking Uniphos 1000 Injection with Clozapine can possibly lead to an interaction. However, they can be taken together if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Uniphos 1000 Injection:
When Uniphos 1000 Injection is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Uniphos 1000 Injection and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLidocaine
Severe
How does the drug interact with Uniphos 1000 Injection:
Taking Lidocaine with Uniphos 1000 Injection may increase the risk of methemoglobinemia (a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Although there is a possible interaction, Uniphos 1000 Injection can be taken with lidocaine if prescribed by the doctor. However, consult the doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue the medication without consulting a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Uniphos 1000 Injection may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Uniphos 1000 Injection can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideTeriflunomide
Severe
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Uniphos 1000 Injection with Teriflunomide can increase the risk of side effects.

How to manage the interaction:
Although taking Uniphos 1000 Injection and Teriflunomide together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any symptoms like fever, chills, sore throat, or muscle aches, it's best to contact a doctor right away. Other symptoms to watch out for include diarrhea, shortness of breath, weight loss, or pain during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideGolimumab
Severe
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Golimumab with Uniphos 1000 Injection may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Uniphos 1000 Injection with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideCladribine
Severe
How does the drug interact with Uniphos 1000 Injection:
The combined use of Cladribine with Uniphos 1000 Injection can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Uniphos 1000 Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Uniphos 1000 Injection Substitute

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Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Uniphos 1000 Injection treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Uniphos 1000 Injection if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Uniphos 1000 Injection. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

FAQs

Uniphos 1000 Injection works by stopping or slowing down the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Uniphos 1000 Injection suppresses the body's immune system and helps treat nephrotic syndrome.

Uniphos 1000 Injection might impair fertility and interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm). Please consult your doctor if you have any concerns.

Men should avoid fathering a child during the treatment and for six months following discontinuation of therapy.

Uniphos 1000 Injection might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding or bruising or if the wounds do not heal properly.

Drug-Drug Interactions Checker List

  • NATALIZUMAB
  • PACLITAXEL
  • ZIDOVUDINE
  • AMIODARONE
  • AMPHOTERICIN B
  • INDOMETHACIN
  • AZATHIOPRINE
  • BUSULFAN

Special Advise

  • Monitoring of complete blood count whilst on treatment with Uniphos 1000 Injection is advised.
  • Women of childbearing potential must use highly effective contraception during treatment and for up to 1 year after the last dose.
  • Male patients who are sexually active with a female partner of child-bearing potential must use condoms during treatment and for up to 6 months after the last dose.

Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner leading to the formation of tumours. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder in which the body excretes too much protein in the urine. Symptoms include foamy urine, weight gain, and swelling around the eyes and in the ankles and feet.

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