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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Uniphos 1000 Injection

Uniphos 1000 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, Uniphos 1000 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Uniphos 1000 Injection contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Uniphos 1000 Injection suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, Uniphos 1000 Injection may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. Uniphos 1000 Injection may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Uniphos 1000 Injection

Malignant diseases (cancer), nephrotic syndrome (kidney disease)

Directions for Use

Uniphos 1000 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Uniphos 1000 Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Uniphos 1000 Injection works by stopping or slowing the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Additionally, Uniphos 1000 Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. Uniphos 1000 Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.

Storage

Store in a cool and dry place away from sunlight
Side effects of Uniphos 1000 Injection
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Your doctor may adjust the dose of the suspected medication based on your immune health; however, do not stop taking it suddenly without consulting them first.
  • Wash your hands often and handle food safely to avoid germs.
  • Get enough sleep and manage your stress levels to help your immune system stay strong.
  • Eat a balanced diet with plenty of vegetables, fruits, whole grains, dairy, and proteins.
  • Do not eat raw eggs, meat, fruits, unpasteurized milk, or uncooked vegetables.
  • Stay away from crowded places and individuals who are sick.
  • Have regular blood tests to check your immune system’s health.
  • Keep your vaccines up-to-date and ask your doctor about which vaccines you need.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Drug Warnings

Do not take Uniphos 1000 Injection if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. Uniphos 1000 Injection may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Uniphos 1000 Injection:
Co-administration of Uniphos 1000 Injection and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Nalidixic acid with Uniphos 1000 Injection may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Uniphos 1000 Injection and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Ropivacaine with Uniphos 1000 Injection can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Uniphos 1000 Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Uniphos 1000 Injection:
When Adalimumab is taken with Uniphos 1000 Injection, may increase the risk of serious infections.

How to manage the interaction:
Although taking Uniphos 1000 Injection and Adalimumab together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Uniphos 1000 Injection:
When Uniphos 1000 Injection is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Uniphos 1000 Injection and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Uniphos 1000 Injection:
Using baricitinib together with Uniphos 1000 Injection may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Uniphos 1000 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Uniphos 1000 Injection:
Taking Uniphos 1000 Injection with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Uniphos 1000 Injection can be taken with Tofacitinib if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Uniphos 1000 Injection:
Coadministration of Tenofovir disoproxil with Uniphos 1000 Injection may increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction, Uniphos 1000 Injection can be taken with Tenofovir disoproxil if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medication without consulting a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Uniphos 1000 Injection with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Uniphos 1000 Injection and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Uniphos 1000 Injection:
Co-administration of Uniphos 1000 Injection with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Uniphos 1000 Injection, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-1000MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Uniphos 1000 Injection treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Uniphos 1000 Injection if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Uniphos 1000 Injection. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-1000MGObstructive and reflux uropathy
Severe
How does the disease interact with Uniphos 1000 Injection:
Uniphos 1000 Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Uniphos 1000 Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Uniphos 1000 Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

FAQs

Uniphos 1000 Injection works by stopping or slowing down the growth of cancer cells in the body. Thereby, Uniphos 1000 Injection helps treat cancer. Uniphos 1000 Injection suppresses the body's immune system and helps treat nephrotic syndrome.

Uniphos 1000 Injection might impair fertility and interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm). Please consult your doctor if you have any concerns.

Men should avoid fathering a child during the treatment and for six months following discontinuation of therapy.

Uniphos 1000 Injection might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding or bruising or if the wounds do not heal properly.

Drug-Drug Interactions Checker List

  • NATALIZUMAB
  • PACLITAXEL
  • ZIDOVUDINE
  • AMIODARONE
  • AMPHOTERICIN B
  • INDOMETHACIN
  • AZATHIOPRINE
  • BUSULFAN

Special Advise

  • Monitoring of complete blood count whilst on treatment with Uniphos 1000 Injection is advised.
  • Women of childbearing potential must use highly effective contraception during treatment and for up to 1 year after the last dose.
  • Male patients who are sexually active with a female partner of child-bearing potential must use condoms during treatment and for up to 6 months after the last dose.

Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner leading to the formation of tumours. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder in which the body excretes too much protein in the urine. Symptoms include foamy urine, weight gain, and swelling around the eyes and in the ankles and feet.

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