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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
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About Esomik D 30mg/20mg Capsule SR

Esomik D 30mg/20mg Capsule SR belongs to a group of gastrointestinal agents used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers and Zollinger-Ellison syndrome.

Esomik D 30mg/20mg Capsule SR is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Esomik D 30mg/20mg Capsule SR helps in treating acidity-related problems.

You are advised to take Esomik D 30mg/20mg Capsule SR for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking Esomik D 30mg/20mg Capsule SR if you are pregnant or breastfeeding. Esomik D 30mg/20mg Capsule SR may cause dizziness, so drive only if you are alert. Esomik D 30mg/20mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol and Esomik D 30mg/20mg Capsule SR as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Esomik D 30mg/20mg Capsule SR

Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, Stomach ulcers

Directions for Use

Take Esomik D 30mg/20mg Capsule SR 1 hour prior to food. Swallow Esomik D 30mg/20mg Capsule SR as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Esomik D 30mg/20mg Capsule SR is a combination of two drugs: Esomeprazole and Domperidone. Esomik D 30mg/20mg Capsule SR is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. It may also be indicated in the treatment of nausea, vomiting, fullness of the stomach, belching, heavy bloating, heartburn, acidity, gas, upper abdominal pain, erosive oesophagitis, and swallowing problems. Esomeprazole is a proton pump inhibitor that blocks an enzyme called gastric proton pump, responsible for acid production. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, Esomik D 30mg/20mg Capsule SR helps in treating acidity-related problems.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Esomik D 30mg/20mg Capsule SR

  • Dry mouth
  • Stomach pain
  • Diarrhoea
  • Headache
  • Flatulence

Drug Warnings

Do not take Esomik D 30mg/20mg Capsule SR if you are allergic to any of its contents or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, or heart problems. Inform your doctor before taking Esomik D 30mg/20mg Capsule SR if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Esomik D 30mg/20mg Capsule SR. On long-term treatment, Esomik D 30mg/20mg Capsule SR may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor if you are pregnant or breastfeeding. Esomik D 30mg/20mg Capsule SR may cause dizziness, so drive only if you are alert. Esomik D 30mg/20mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol along with Esomik D 30mg/20mg Capsule SR as it could lead to increased drowsiness and can elevate the production of stomach acid. A prolonged intake of Esomik D 30mg/20mg Capsule SR is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
EsomeprazoleClopidogrel
Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Esomik D 30mg/20mg Capsule SR may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
EsomeprazoleClopidogrel
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Coadministration of Clopidogrel with Esomik D 30mg/20mg Capsule SR may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Esomik D 30mg/20mg Capsule SR together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleErlotinib
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Coadministration of erlotinib and Esomik D 30mg/20mg Capsule SR can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Esomik D 30mg/20mg Capsule SR together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
EsomeprazoleDacomitinib
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Esomik D 30mg/20mg Capsule SR can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Esomik D 30mg/20mg Capsule SR with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleDasatinib
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Using Dasatinib together with Esomik D 30mg/20mg Capsule SR may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
EsomeprazoleNelfinavir
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Taking nelfinavir with Esomik D 30mg/20mg Capsule SR may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
EsomeprazoleTacrolimus
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Taking tacrolimus with Esomik D 30mg/20mg Capsule SR may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.
EsomeprazoleAtazanavir
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Esomik D 30mg/20mg Capsule SR reduces the absorption of atazanavir, resulting in reduced efficacy of atazanavir.

How to manage the interaction:
Although there is a possible interaction between Esomik D 30mg/20mg Capsule SR and atazanavir, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
EsomeprazoleGefitinib
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Taking gefitinib with Esomik D 30mg/20mg Capsule SR may reduce the effectiveness of gefitinib.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR and Gefitinib together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Gefitionib 12 hours before or after taking Esomik D 30mg/20mg Capsule SR. Do not stop taking any medications without consulting a doctor.
EsomeprazoleMethotrexate
Severe
How does the drug interact with Esomik D 30mg/20mg Capsule SR:
Co-administration of methotrexate and Esomik D 30mg/20mg Capsule SR can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Esomik D 30mg/20mg Capsule SR with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Esomik D 30mg/20mg Capsule SR Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Esomik D 30mg/20mg Capsule SR contains Esomeprazole and Domperidone. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Esomik D 30mg/20mg Capsule SR helps in treating acidity.

Diarrhoea might be a side-effect of Esomik D 30mg/20mg Capsule SR. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience excessive diarrhoea or if you find blood in your stools.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Dry mouth could be a side-effect of Esomik D 30mg/20mg Capsule SR. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.

Esomik D 30mg/20mg Capsule SR contains domperidone which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscles.

Do not take Esomik D 30mg/20mg Capsule SR for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Esomik D 30mg/20mg Capsule SR for 14days.

Esomik D 30mg/20mg Capsule SR should not be taken along with HIV medicines such as atazanavir, ritonavir, nelfinavir, and saquinavir as Esomik D 30mg/20mg Capsule SR might affect their absorption. Consult your doctor before taking Esomik D 30mg/20mg Capsule SR with other medicines to avoid unpleasant side-effects.

On long-term treatment, Esomik D 30mg/20mg Capsule SR might increase the risk of bone fracture in the spine, wrist or hip. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, as they can increase the risk of bone fractures.

Drug-Drug Interactions Checker List

  • ATAZANAVIR
  • SAQUINAVIR
  • RITONAVIR
  • NELFINAVIR
  • WARFARIN
  • CLOPIDOGREL
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • FLUCONAZOLE
  • ERLOTINIB
  • TOREMIFENE
  • VANDETANIB
  • VINCAMINE
  • DIAZEPAM
  • PHENYTOIN
  • CILOSTAZOL
  • CISAPRIDE
  • DOLASETRON
  • TACROLIMUS
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • MOXIFLOXACIN
  • PENTAMIDINE
  • TELITHROMYCIN
  • LEVOTHYROXINE
  • METHOTREXATE
  • CITALOPRAM
  • ESCITALOPRAM
  • DIGOXIN
  • HALOFANTRINE
  • HALOPERIDOL
  • PIMOZIDE
  • SERTINDOLE
  • MEQUITAZINE
  • MIZOLASTINE
  • AMIODARONE
  • DRONEDARONE
  • QUINIDINE
  • DISOPYRAMIDE
  • DOFETILIDE
  • SOTALOL
  • DILTIAZEM
  • VERAMAPIL

Special Advise

  • Inform your doctor before taking Esomik D 30mg/20mg Capsule SR if you are due to have Chromogranin A blood test.
  • Esomik D 30mg/20mg Capsule SR may cause changes in blood tests. Inform the person doing the tests that you are taking Esomik D 30mg/20mg Capsule SR.

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.

Stomach/Peptic ulcers: They are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.

Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting. 

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