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  3. Esopera LS Capsule 10's

Esopera LS Capsule 10's, Pack of 10 CapsuleS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Whats That

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Composition :

ESOMEPRAZOLE-40MG + LEVOSULPIRIDE-75MG

Manufacturer/Marketer :

Unipark Biotech Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Esopera LS Capsule

Esopera LS Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

Esopera LS Capsule contains Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Esopera LS Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

You are advised to take Esopera LS Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Inform your doctor before taking Esopera LS Capsule if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Esopera LS Capsule may increase the risk of bone fractures. Consult your doctor if you are pregnant or breastfeeding. Esopera LS Capsule may cause drowsiness and dizziness, so drive only if you are alert. Esopera LS Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Esopera LS Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Uses of Esopera LS Capsule

Gastro-oesophageal reflux disease.

Directions for Use

Take Esopera LS Capsule 1hour prior food. Swallow Esopera LS Capsule as a whole with a glass of water, do not chew, or crush it.

Medicinal Benefits

Esopera LS Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Esopera LS Capsule is a combination of two drugs, namely: Esomeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Esopera LS Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Esopera LS Capsule if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Esopera LS Capsule if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Esopera LS Capsule may increase the risk of bone fractures. Do not take Esopera LS Capsule if you are pregnant or breastfeeding. Esopera LS Capsule may cause dizziness and drowsiness, so drive only if you are alert. Esopera LS Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Esopera LS Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid. 

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
EsomeprazoleCitalopram
Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Esopera LS Capsule:
Esopera LS Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Esopera LS Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
EsomeprazoleCitalopram
Severe
How does the drug interact with Esopera LS Capsule:
Combining Esopera LS Capsule with Citalopram can increase the risk of irregular heart rhythm. .

How to manage the interaction:
Co-administration of Esopera LS Capsule with Citalopram can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, it's important to contact your doctor immediately. Do not stop using any medications without a doctor's advice.
EsomeprazoleTacrolimus
Severe
How does the drug interact with Esopera LS Capsule:
Taking tacrolimus with Esopera LS Capsule may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Esopera LS Capsule with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.
EsomeprazoleClopidogrel
Severe
How does the drug interact with Esopera LS Capsule:
Coadministration of Clopidogrel with Esopera LS Capsule may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Esopera LS Capsule together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazolePazopanib
Severe
How does the drug interact with Esopera LS Capsule:
Esopera LS Capsule decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Esopera LS Capsule and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
EsomeprazoleDasatinib
Severe
How does the drug interact with Esopera LS Capsule:
Using Dasatinib together with Esopera LS Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Esopera LS Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
EsomeprazoleErlotinib
Severe
How does the drug interact with Esopera LS Capsule:
Coadministration of erlotinib and Esopera LS Capsule can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Esopera LS Capsule together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
EsomeprazoleDacomitinib
Severe
How does the drug interact with Esopera LS Capsule:
Esopera LS Capsule can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Esopera LS Capsule with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleMethotrexate
Severe
How does the drug interact with Esopera LS Capsule:
Co-administration of methotrexate and Esopera LS Capsule can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Esopera LS Capsule with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
EsomeprazoleNelfinavir
Severe
How does the drug interact with Esopera LS Capsule:
Taking nelfinavir with Esopera LS Capsule may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Esopera LS Capsule and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Esopera LS Capsule Substitute

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:31 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Esopera LS Capsule is a combination of two drugs, namely: Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Esopera LS Capsule helps in preventing acid reflux, thereby providing relief from acidity.

Diarrhoea might be a side-effect of Esopera LS Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Do not take Esopera LS Capsule with nelfinavir (a drug used to treat HIV infections). Consult your doctor before taking Esopera LS Capsule with other medicines to rule out unpleasant side-effects.

Esopera LS Capsule contains esomeprazole which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking Esopera LS Capsule for longer durations. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, your doctor may prescribe calcium and vitamin D supplements.

Esopera LS Capsule may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Esopera LS Capsule .

Dry mouth could be a side-effect of Esopera LS Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • NAPROXEN
  • ATAZANAVIR
  • CLOPIDOGREL
  • WARFARIN
  • CILOSTAZOL
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • ERLOTINIB
  • METHOTREXATE
  • CITALOPRAM
  • IMIPRAMINE
  • CLOMIPRAMINE
  • DULOXETINE
  • DIAZEPAM
  • PHENYTOIN
  • CISAPRIDE
  • DIGOXIN
  • TACROLIMUS
  • RIFAMPICIN

Special Advise

  • Esopera LS Capsule may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Esopera LS Capsule .
  • Inform your doctor before taking Esopera LS Capsule if you are due to have Chromogranin A test.

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

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