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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS

About Espazine Plus Tablet 10's

Espazine Plus Tablet 10's belongs to a class of drugs called 'antipsychotics' used to prevent and treat schizophrenia (a mental illness). Additionally, Espazine Plus Tablet 10's may be used to anxiety and depression over a short period. Schizophrenia is a mental disorder that affects a person's ability to feel, think and behave clearly. Anxiety is a mental health disorder associated with fear, worry, and excessive nervousness that may interfere with daily activities. Depression is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.

Espazine Plus Tablet 10's combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, Espazine Plus Tablet 10's helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic. On the other hand, Trihexyphenidyl is an anticholinergic agent that acts on the nervous system and corrects some of the chemical imbalances that cause some side effects such as shaking of hands and muscle spasms due to Trifluoperazine.

Take Espazine Plus Tablet 10's as prescribed by your doctor. You are advised to take Espazine Plus Tablet 10's for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience nausea, constipation, dryness in the mouth, sedation, weight gain, orthostatic hypotension (sudden lowering of blood pressure on standing), urinary retention, increased prolactin level in the blood, dizziness, blurred vision, and nervousness. Most of these side effects of Espazine Plus Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Espazine Plus Tablet 10's or any other medicines, please tell your doctor. Avoid taking Espazine Plus Tablet 10's if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Espazine Plus Tablet 10's should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Avoid consuming alcohol along with Espazine Plus Tablet 10's as it could lead to increased drowsiness and dizziness. Consult your doctor before giving this medicine to your child. Keep your doctor informed about your medicines and health condition and rule out any side effects. 

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

Uses of Espazine Plus Tablet 10's

Schizophrenia, Anxiety, Depression

Medicinal Benefits

Espazine Plus Tablet 10's combination composed of two different medicines, namely; Trifluoperazine and Trihexyphenidyl used to prevent and treat relapses of schizophrenia (a mental illness). Additionally, Espazine Plus Tablet 10's may be used to anxiety and depression over a short period. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behavior, and emotions. Thereby, Espazine Plus Tablet 10's helps in controlling psychotic illness, relieving depression, lighten the mood, and relieve anxiety symptoms such as fear and panic. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms, etc.). On the other hand, Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine. Trihexyphenidyl exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. Espazine Plus Tablet 10's improves muscle control and reduces stiffness, thereby helps the muscles move naturally. 

Side Effects of Espazine Plus Tablet 10's

  • Nausea
  • Constipation
  • Dry mouth
  • Sedation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in the blood
  • Dizziness
  • Abdominal Pain
  • Excessive sweating
  • Decreased blood pressure
  • Urine retention
  • Blurred vision
  • Nervousness

Directions for Use

Swallow Espazine Plus Tablet 10's as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Espazine Plus Tablet 10's or any other medicines, please tell your doctor. Avoid taking Espazine Plus Tablet 10's if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Espazine Plus Tablet 10's should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Do not discontinue Espazine Plus Tablet 10's on your own. Inform your doctor before taking Espazine Plus Tablet 10's if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver, or kidney problems. Talk to your doctor immediately if you experience hallucinations. Espazine Plus Tablet 10's may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. Espazine Plus Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with Espazine Plus Tablet 10's as it could lead to increased drowsiness and dizziness. 

Therapeutic Class

ANTIPSYCHOTICS

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
TrihexyphenidylPotassium chloride
Critical

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Espazine Plus Tablet 10's:
Co-administration of Espazine Plus Tablet 10's with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Espazine Plus Tablet 10's with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Espazine Plus Tablet 10's:
Co-administration of Espazine Plus Tablet 10's with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Espazine Plus Tablet 10's with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrifluoperazineZiprasidone
Critical
How does the drug interact with Espazine Plus Tablet 10's:
Co-administration of Espazine Plus Tablet 10's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Espazine Plus Tablet 10's with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrifluoperazineMetoclopramide
Critical
How does the drug interact with Espazine Plus Tablet 10's:
Co-administration of Metoclopramide with Espazine Plus Tablet 10's can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Metoclopramide with Espazine Plus Tablet 10's is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylKetamine
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Taking Espazine Plus Tablet 10's with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Espazine Plus Tablet 10's and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylZonisamide
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Coadministration of Espazine Plus Tablet 10's with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Espazine Plus Tablet 10's with Zonisamide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Taking Espazine Plus Tablet 10's with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Espazine Plus Tablet 10's and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylTopiramate
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Taking Espazine Plus Tablet 10's with topiramate can increase the risk of increase body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Espazine Plus Tablet 10's with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness or lightheaded, increase body temperature contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrihexyphenidylAmantadine
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Coadministration of Allopurinol with Espazine Plus Tablet 10's may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Espazine Plus Tablet 10's together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
TrifluoperazineMorphine
Severe
How does the drug interact with Espazine Plus Tablet 10's:
Using Morphine together with Espazine Plus Tablet 10's can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Espazine Plus Tablet 10's can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • GUANETHIDINE
  • CODEINE
  • ATROPINE
  • PROCYCLIDINE
  • PROMAZINE
  • PROCHLORPERAZINE
  • CHLORPROMAZINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • OLANZAPINE
  • RISPERIDONE
  • QUETIAPINE
  • TRIFLUOPERAZINE
  • LAMOTRIGINE
  • CLONAZEPAM
  • PREGABALIN
  • LEVODOPA
  • WARFARIN
  • DESFERRIOXAMINE
  • DISOPYRAMIDE
  • PROCAINAMIDE
  • QUINIDINE
  • AMIODARONE
  • SOTALOL
  • DIPHENHYDRAMINE
  • BENZTROPINE MESYLATE
  • ESCITALOPRAM
  • DULOXETINE
  • ALPRAZOLAM
  • ACETAMINOPHEN

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate, and magnesium. 
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Special Advise

  • If you are going to have a special X-ray examination of the spinal cord or brain involving metrizamide (chemical), inform your doctor that you are taking Espazine Plus Tablet 10's.
  • Blood tests are recommended while taking Espazine Plus Tablet 10's to monitor blood counts and liver functioning.
  • This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Author Details

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Disease/Condition Glossary

Schizophrenia: It is a mental disorder that affects a person's ability to feel, think and behave clearly. The symptoms include hallucinations, thought or movement disorders, delusions (misbelief), lack of emotion, sleep problems, isolation from family and friends and difficulty in doing daily activities.

Anxiety: It is a mental health disorder associated with fear, worry and excessive nervousness that may interfere with daily activities. The anxiety symptoms include feeling more stress than required for that event and lack of ability to set aside restlessness and worry. Anxiety can be treated by psychotherapy (meeting a psychologist) or medications.

Depression: It is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.

Espazine Plus Tablet 10's Substitute

Substitutes safety advice
  • Trinicalm Plus Tablet 10's

    2.66per tablet
  • Parkin Plus Tablet 10's

    3.51per tablet
  • Trazine-S Tablet 10's

    2.30per tablet
  • Lacalm Plus Tablet 10's

    1.62per tablet
  • NEOCALM PLUS TABLET

    1.40per tablet
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