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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Espra DSR Capsule

Espra DSR Capsule belongs to a group of gastrointestinal agents used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers and Zollinger-Ellison syndrome.

Espra DSR Capsule is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Espra DSR Capsule helps in treating acidity-related problems.

You are advised to take Espra DSR Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking Espra DSR Capsule if you are pregnant or breastfeeding. Espra DSR Capsule may cause dizziness, so drive only if you are alert. Espra DSR Capsule should not be given to children as safety has not been established. Avoid consuming alcohol and Espra DSR Capsule as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Espra DSR Capsule

Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, Stomach ulcers

Directions for Use

Take Espra DSR Capsule 1 hour prior to food. Swallow Espra DSR Capsule as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Espra DSR Capsule is a combination of two drugs: Esomeprazole and Domperidone. Espra DSR Capsule is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. It may also be indicated in the treatment of nausea, vomiting, fullness of the stomach, belching, heavy bloating, heartburn, acidity, gas, upper abdominal pain, erosive oesophagitis, and swallowing problems. Esomeprazole is a proton pump inhibitor that blocks an enzyme called gastric proton pump, responsible for acid production. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, Espra DSR Capsule helps in treating acidity-related problems.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Espra DSR Capsule

  • Dry mouth
  • Stomach pain
  • Diarrhoea
  • Headache
  • Flatulence

Drug Warnings

Do not take Espra DSR Capsule if you are allergic to any of its contents or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, or heart problems. Inform your doctor before taking Espra DSR Capsule if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Espra DSR Capsule . On long-term treatment, Espra DSR Capsule may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor if you are pregnant or breastfeeding. Espra DSR Capsule may cause dizziness, so drive only if you are alert. Espra DSR Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Espra DSR Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid. A prolonged intake of Espra DSR Capsule is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
NaproxenCidofovir
Critical

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Espra DSR Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
NaproxenCidofovir
Critical
How does the drug interact with Espra DSR Capsule:
Taking cidofovir with Espra DSR Capsule may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Espra DSR Capsule with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
NaproxenKetorolac
Critical
How does the drug interact with Espra DSR Capsule:
Coadministration of Ketorolac with Espra DSR Capsule can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Espra DSR Capsule together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
NaproxenMeloxicam
Critical
How does the drug interact with Espra DSR Capsule:
Co-administration of Espra DSR Capsule with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Espra DSR Capsule is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
EsomeprazoleDasatinib
Severe
How does the drug interact with Espra DSR Capsule:
Using Dasatinib together with Espra DSR Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Espra DSR Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
EsomeprazoleGefitinib
Severe
How does the drug interact with Espra DSR Capsule:
Taking gefitinib with Espra DSR Capsule may reduce the effectiveness of gefitinib.

How to manage the interaction:
Although taking Espra DSR Capsule and Gefitinib together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Gefitionib 12 hours before or after taking Espra DSR Capsule. Do not stop taking any medications without consulting a doctor.
EsomeprazolePazopanib
Severe
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Espra DSR Capsule and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.
EsomeprazoleMethotrexate
Severe
How does the drug interact with Espra DSR Capsule:
Co-administration of methotrexate and Espra DSR Capsule can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Espra DSR Capsule with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
EsomeprazoleDacomitinib
Severe
How does the drug interact with Espra DSR Capsule:
Espra DSR Capsule can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Espra DSR Capsule with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EsomeprazoleClopidogrel
Severe
How does the drug interact with Espra DSR Capsule:
Coadministration of Clopidogrel with Espra DSR Capsule may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Espra DSR Capsule together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Espra DSR Capsule Substitute

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Espra DSR Capsule contains Esomeprazole and Domperidone. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Espra DSR Capsule helps in treating acidity.

Diarrhoea might be a side-effect of Espra DSR Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience excessive diarrhoea or if you find blood in your stools.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Dry mouth could be a side-effect of Espra DSR Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.

Espra DSR Capsule contains domperidone which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscles.

Do not take Espra DSR Capsule for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Espra DSR Capsule for 14days.

Espra DSR Capsule should not be taken along with HIV medicines such as atazanavir, ritonavir, nelfinavir, and saquinavir as Espra DSR Capsule might affect their absorption. Consult your doctor before taking Espra DSR Capsule with other medicines to avoid unpleasant side-effects.

On long-term treatment, Espra DSR Capsule might increase the risk of bone fracture in the spine, wrist or hip. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, as they can increase the risk of bone fractures.

Drug-Drug Interactions Checker List

  • ATAZANAVIR
  • SAQUINAVIR
  • RITONAVIR
  • NELFINAVIR
  • WARFARIN
  • CLOPIDOGREL
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • FLUCONAZOLE
  • ERLOTINIB
  • TOREMIFENE
  • VANDETANIB
  • VINCAMINE
  • DIAZEPAM
  • PHENYTOIN
  • CILOSTAZOL
  • CISAPRIDE
  • DOLASETRON
  • TACROLIMUS
  • RIFAMPICIN
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • MOXIFLOXACIN
  • PENTAMIDINE
  • TELITHROMYCIN
  • LEVOTHYROXINE
  • METHOTREXATE
  • CITALOPRAM
  • ESCITALOPRAM
  • DIGOXIN
  • HALOFANTRINE
  • HALOPERIDOL
  • PIMOZIDE
  • SERTINDOLE
  • MEQUITAZINE
  • MIZOLASTINE
  • AMIODARONE
  • DRONEDARONE
  • QUINIDINE
  • DISOPYRAMIDE
  • DOFETILIDE
  • SOTALOL
  • DILTIAZEM
  • VERAMAPIL

Special Advise

  • Inform your doctor before taking Espra DSR Capsule if you are due to have Chromogranin A blood test.
  • Espra DSR Capsule may cause changes in blood tests. Inform the person doing the tests that you are taking Espra DSR Capsule .

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.

Stomach/Peptic ulcers: They are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.

Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting. 

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