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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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About Flulast PR 20mg/10mg Tablet

Flulast PR 20mg/10mg Tablet belongs to the class of 'anti-migraine drugs' primarily used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Flulast PR 20mg/10mg Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It is also used to treat vertigo (spinning sensation).

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Flulast PR 20mg/10mg Tablet include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Flulast PR 20mg/10mg Tablet. Flulast PR 20mg/10mg Tablet may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking Flulast PR 20mg/10mg Tablet if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol along with Flulast PR 20mg/10mg Tablet as it could lead to increased drowsiness.

Uses of Flulast PR 20mg/10mg Tablet

Migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew, crush or break it.

Medicinal Benefits

Flulast PR 20mg/10mg Tablet is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you have any history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, atrioventricular block), overactive thyroid, blood circulation problems (Raynaud's disease), adrenal gland tumour (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting Flulast PR 20mg/10mg Tablet. Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you Flulast PR 20mg/10mg Tablet. Avoid consuming alcohol along with Flulast PR 20mg/10mg Tablet as it could lead to increased dizziness and drowsiness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of thioridazine with Flulast PR 20mg/10mg Tablet may increase the blood levels of thioridazine and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Flulast PR 20mg/10mg Tablet and thioridazine, they can be taken together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, and shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Co-administration of Bisoprolol with Flulast PR 20mg/10mg Tablet may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with Flulast PR 20mg/10mg Tablet if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololIndacaterol
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Using Flulast PR 20mg/10mg Tablet together with indacaterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Flulast PR 20mg/10mg Tablet can cause breathing problems.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Indacaterol can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of Flulast PR 20mg/10mg Tablet and levosalbutamol can increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Flulast PR 20mg/10mg Tablet and levosalbutamol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololIobenguane (131i)
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of iobenguane (131i) and Flulast PR 20mg/10mg Tablet may interfere with the effects of iobenguane I-131 in treating your condition.

How to manage the interaction:
Although there is a possible interaction between Flulast PR 20mg/10mg Tablet and Iobenguane (131i), you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Using Flulast PR 20mg/10mg Tablet and salbutamol together can reduce the effects or increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of Flulast PR 20mg/10mg Tablet and salbutamol can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Taking atenolol and Flulast PR 20mg/10mg Tablet together may lower your blood pressure excessively which may lead to side effects.

How to manage the interaction:
Combined use of atenolol and Flulast PR 20mg/10mg Tablet may result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Using Flulast PR 20mg/10mg Tablet together with Theophylline makes the Flulast PR 20mg/10mg Tablet less effective in controlling blood pressure, and it also increases the effects of theophylline

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Theophylline can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience nausea, vomiting, sleeplessness, tremors, restlessness, irregular heartbeats, or difficulty breathing. Do not stop using any medication without consulting a doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Taking Flulast PR 20mg/10mg Tablet and Diltiazem together increases the risk of side effects.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Diltiazem can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. Do not stop using any medications without consulting your doctor.
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of rivastigmine with Flulast PR 20mg/10mg Tablet can cause an abnormally slow heart rate and low blood pressure.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Rivastigmine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience lightheadedness, dizziness, fainting, or irregular heartbeat. Do not discontinue any medicine without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to Flulast PR 20mg/10mg Tablet.
  • Avoid loud music, extreme temperatures, bright lights, and noisy places as it can increase headache.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine to relieve headaches.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Flulast PR 20mg/10mg Tablet is a combination of two drugs: Propranolol and Flunarizine. Flulast PR 20mg/10mg Tablet treats migraine by reducing the blood flow to the brain, and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation.

Flulast PR 20mg/10mg Tablet may sometimes cause weight gain during its prolonged use. It is always advised to maintain a well-balanced, healthy diet and exercise regularly.

Flulast PR 20mg/10mg Tablet does not work for a sudden migraine attack. It is helpful in only preventing new episodes of migraine headaches. Please let your doctor know if you have sudden attacks to be prescribed other suitable medications.

Flulast PR 20mg/10mg Tablet is contraindicated in asthma, slow heart rate, abnormal heart rhythms, heart conditions like AV (Atrioventricular) block or sick sinus syndrome, depression, and Parkinson's disease. Please consult your doctor before starting Flulast PR 20mg/10mg Tablet if you have a medical history.

Your doctor will prescribe Flulast PR 20mg/10mg Tablet to prevent any new episodes of migraine. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of migraine. Flulast PR 20mg/10mg Tablet also contains Propranolol, and its sudden withdrawal may cause sweating, shaking, irregular heartbeat, and worsening of underlying angina or heart attack. Hence, do not stop using Flulast PR 20mg/10mg Tablet unless advised by your doctor.

Drug-Drug Interactions Checker List

  • ALPRAZOLAM
  • QUETIAPINE
  • ARIPIPRAZOLE
  • ZOLPIDEM
  • DIPHENHYDRAMINE
  • SERTRALINE
  • DULOXETINE
  • FLUOXETINE
  • CARBAMAZEPINE
  • PHENYTOIN

Special Advise

  • Let your doctor know that you are taking Flulast PR 20mg/10mg Tablet if you are undergoing any medical tests.
  • Beta-blockers like Propranolol can mask hypoglycaemia symptoms (low blood sugar) or hyperthyroidism (high thyroid levels).
  • It is advised to inform your doctor if you have diabetes or thyroid disease before using Flulast PR 20mg/10mg Tablet.
  • Beta-blockers can also cause changes in serum lipid profiles. Patients with pre-existing hyperlipidaemia (high lipid levels) should be closely monitored if using Flulast PR 20mg/10mg Tablet.

Disease/Condition Glossary

Migraine: It is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Symptoms of migraine may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine can be triggered by various factors like foods (eggs, tomatoes, onions, dairy products, wheat, pasta, citrus fruits, nitrites found in foods, alcohol, and red wine), hormonal changes, sleep changes, stress, loud noises, and medications.

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