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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

About Folitrax-25 Injection 1 ml

Folitrax-25 Injection 1 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis. Folitrax-25 Injection 1 ml is also used to treat cancer such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), bone cancer, and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Folitrax-25 Injection 1 ml contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-25 Injection 1 ml prevents and stops the growth of cancer cells, thereby helps treat cancer. Folitrax-25 Injection 1 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Folitrax-25 Injection 1 ml will be administered by a qualified healthcare professional; do not self-administer. In some cases, Folitrax-25 Injection 1 ml may cause side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience any of the side effects persistently.

Do not take Folitrax-25 Injection 1 ml if you are pregnant or breastfeeding. Folitrax-25 Injection 1 ml may cause dizziness and fatigue, so avoid driving or operating machinery. Avoid consuming alcohol whilst on treatment with Folitrax-25 Injection 1 ml. If you are due to undergo any surgery, including dental surgery, inform the doctor that you are receiving Folitrax-25 Injection 1 ml. Do not have any vaccinations during treatment with Folitrax-25 Injection 1 ml without consulting your doctor. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Ipca Laboratories Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Folitrax-25 Injection 1 ml

Rheumatoid arthritis, Psoriasis, Cancer

Medicinal Benefits

Folitrax-25 Injection 1 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis including polyarticular juvenile rheumatoid arthritis (arthritis in children) and severe psoriasis. Folitrax-25 Injection 1 ml helps treat rheumatoid arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Folitrax-25 Injection 1 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-25 Injection 1 ml is used to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Folitrax-25 Injection 1 ml prevents and stops the growth of cancer cells by interfering with DNA production.

Side Effects of Folitrax-25 Injection 1 ml

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Directions for Use

Folitrax-25 Injection 1 ml will be administered by a qualified healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Folitrax-25 Injection 1 ml if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Folitrax-25 Injection 1 ml may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive Folitrax-25 Injection 1 ml while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Therapeutic Class

ANTIMETABOLITES

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateAcitretin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Etretinate with Folitrax-25 Injection 1 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Folitrax-25 Injection 1 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Acitretin with Folitrax-25 Injection 1 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Folitrax-25 Injection 1 ml, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateAmpicillin
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Folitrax-25 Injection 1 ml with Ampicillin can increase the levels and side effects of Folitrax-25 Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Folitrax-25 Injection 1 ml and ampicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEtodolac
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Folitrax-25 Injection 1 ml with etodolac can increase the level and effects of Folitrax-25 Injection 1 ml. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Folitrax-25 Injection 1 ml and etodolac, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexatePiroxicam
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Coadministration of Folitrax-25 Injection 1 ml with piroxicam can increase the levels and side effects.

How to manage the interaction:
Although there is a possible interaction between piroxicam and Folitrax-25 Injection 1 ml, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateBaricitinib
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Baricitinib and Folitrax-25 Injection 1 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Folitrax-25 Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateTacrolimus
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Taking tacrolimus with Folitrax-25 Injection 1 ml may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Folitrax-25 Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateMefenamic acid
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Coadministration of Mefenamic acid with Folitrax-25 Injection 1 ml may increase the blood levels and side effects of Folitrax-25 Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between mefenamic acid and Folitrax-25 Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), mouth sores or ulcers, infection, as well as flu-like symptoms(fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateCladribine
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Co-administration of Folitrax-25 Injection 1 ml with cladribine can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cladribine and Folitrax-25 Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateOxacillin
Severe
How does the drug interact with Folitrax-25 Injection 1 ml:
Coadministration of Folitrax-25 Injection 1 ml with oxacillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between oxacillin and Folitrax-25 Injection 1 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CISPLATIN
  • MERCAPTOPURINE
  • AZATHIOPRINE
  • TETRACYCLINE
  • CHLORAMPHENICOL
  • SULFASALAZINE

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Special Advise

  • Women of child-bearing potential must use effective contraception whilst on treatment with Folitrax-25 Injection 1 ml and for at least 6 months after the last dose.
  • If you are a male, you and your partner should use reliable contraception during treatment with Folitrax-25 Injection 1 ml and for at least 3 months after the last dose.
  • Folitrax-25 Injection 1 ml may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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