apollo
0
Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

tooltip

Manufacturer/Marketer :

Alena Lifesciences Llp

Consume Type :

ORAL

Return Policy :

Not Returnable

About Fotrex Combikit Tablet 24+4's

Fotrex Combikit Tablet 24+4's belongs to the class of 'antimetabolite agents' primarily used to treat rheumatoid arthritis, psoriasis and juvenile idiopathic arthritis. Fotrex Combikit Tablet 24+4's is also used to treat leukaemia (blood cancer), Non-Hodgkin's lymphoma (cancer of the lymphatic system), soft tissue and bone cancer and certain types of cancer/tumours breast, skin, head and neck, lung or uterus. Fotrex Combikit Tablet 24+4's reduces the immune system's strength to treat conditions of autoimmune diseases. Arthritis is an autoimmune disease which leads to joint pain and damage.

Fotrex Combikit Tablet 24+4's contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy.

Your doctor will decide the dosage based on your medical condition. In some cases, you may experience common side effects, such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach upset, stomach pain, leukopenia (decreased number of white blood cells) and soreness of mouth and lips. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are known to be allergic to Fotrex Combikit Tablet 24+4's or its inactive components, please inform your doctor. Do not take Fotrex Combikit Tablet 24+4's if you are pregnant or planning for pregnancy, as Fotrex Combikit Tablet 24+4's causes serious congenital disabilities. Fotrex Combikit Tablet 24+4's should not be taken by breastfeeding mothers as it passes into breast milk. Fotrex Combikit Tablet 24+4's can cause dizziness and drowsiness; hence drive with caution. Fotrex Combikit Tablet 24+4's should not be given to children below three years of age, as safety and efficacy have not been established. Avoid consuming alcohol along with Fotrex Combikit Tablet 24+4's as it could lead to increased dizziness. 

Uses of Fotrex Combikit Tablet 24+4's

Rheumatoid arthritis, Psoriatic arthritis, Juvenile idiopathic arthritis, Psoriasis, and Cancer.

Directions for Use

Swallow Fotrex Combikit Tablet 24+4's as a whole with a glass of water. Take Fotrex Combikit Tablet 24+4's one hour after food, once every week. Take Fotrex Combikit Tablet 24+4's on the same day each week. Do not crush, chew or break it.

Medicinal Benefits

Fotrex Combikit Tablet 24+4's treats rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, leukaemia and cancer/tumours of the breast, skin, head and neck, lung, or uterus. It contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin B9). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It reduces pain and inflammation and slows down joint damage and disease progression over time. Hence, it is also known as a disease-modifying anti-rheumatic drug (DMARD). It also acts as an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is a water-soluble Vitamin B. It helps in the formation of red blood cells and prevents DNA changes that may lead to cancer. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Fotrex Combikit Tablet 24+4's or its inactive components, please inform your doctor. Brief your medical history if you have any liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis), and active infections (including chickenpox). Fotrex Combikit Tablet 24+4's is contraindicated during pregnancy since it has harmful effects on the foetus. Please get a pregnancy test done before starting Fotrex Combikit Tablet 24+4's. You should get a negative pregnancy test for sure before using Fotrex Combikit Tablet 24+4's. Use reliable forms of birth control if you are undergoing treatment with Fotrex Combikit Tablet 24+4's to avoid pregnancy. Fotrex Combikit Tablet 24+4's should not be taken by breastfeeding mothers since it is excreted into the breast milk. Fotrex Combikit Tablet 24+4's can cause dizziness and drowsiness; hence drive with caution. Avoid consuming alcohol along with Fotrex Combikit Tablet 24+4's as it could lead to increased dizziness. Fotrex Combikit Tablet 24+4's should not be given to children below three years of age, as safety and efficacy have not been established. 

Drug-Drug Interactions

verifiedApollotooltip
MethotrexateEtretinate
Critical

Drug-Drug Interactions

Login/Sign Up

MethotrexateEtretinate
Critical
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Etretinate with Fotrex Combikit Tablet 24+4's may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Fotrex Combikit Tablet 24+4's is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with etanercept can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between etanercept and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Combine use of entecavir with Fotrex Combikit Tablet 24+4's may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Using thalidomide together with Fotrex Combikit Tablet 24+4's can increase the risk of developing blood clots.

How to manage the interaction:
Although there is a possible interaction between thalidoamide and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult your doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with aspirin can increase the levels and side effects of Fotrex Combikit Tablet 24+4's.

How to manage the interaction:
Although there is a possible interaction between aspirin and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience symptoms such as nausea, vomiting, diarrhea, sore throat, chills, fever, rash, unusual bruising or bleeding, pale skin, dark urine, swelling of the legs and hands, breathing difficulty. Do not stop using any medications without consulting a doctor.
MethotrexateNafcillin
Severe
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Coadministration of Fotrex Combikit Tablet 24+4's with nafcillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between nafcillin and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, nausea, vomiting, mouth ulcers, sore throat, body aches, or other flu-like symptoms, consult the doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's with Rabeprazole can increase the blood levels and side effects of Fotrex Combikit Tablet 24+4's.

How to manage the interaction:
Although there is a possible interaction between Rabeprazole and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Fotrex Combikit Tablet 24+4's and esomeprazole can increase the blood levels and side effects of Fotrex Combikit Tablet 24+4's.

How to manage the interaction:
Although taking Esomeprazole with Fotrex Combikit Tablet 24+4's can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Coadministration of omeprazole with Fotrex Combikit Tablet 24+4's may increase the levels and side effects of omeprazole.

How to manage the interaction:
Although there is a possible interaction between omeprazole and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Fotrex Combikit Tablet 24+4's:
Co-administration of Meloxicam with Fotrex Combikit Tablet 24+4's may increase the levels and side effects of Meloxicam.

How to manage the interaction:
Although there is a possible interaction between meloxicam and Fotrex Combikit Tablet 24+4's, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants, such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

Login/Sign Up

FAQs

Fotrex Combikit Tablet 24+4's contains Methotrexate and Folic acid. Methotrexate acts as an immunosuppressant and works by suppressing the overactive immune system that causes inflammation in the cells and tissues, thus preventing various autoimmune diseases. Folic acid is used to replace the folic acid deficiency caused by Methotrexate.

Fotrex Combikit Tablet 24+4's works by suppressing the overactive immune system responsible for causing psoriasis. Fotrex Combikit Tablet 24+4's interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Fotrex Combikit Tablet 24+4's. Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Methotrexate in Fotrex Combikit Tablet 24+4's causes leukopenia (decreased number of white blood cells) and may make you more susceptible to infections. Stay away from people with active infections. Consult your doctor if you develop any signs of infections, such as fever, sore throat, breathlessness, jaundice and unexplained bleeding or bruising.

Fotrex Combikit Tablet 24+4's should be used with caution if you have a medical history of liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis) and active infections (including chickenpox).

Drug-Drug Interactions Checker List

  • DICLOFENAC
  • IBUPROFEN
  • CELECOXIB
  • MELOXICAM
  • ACETAMINOPHEN
  • HYDROCODONE
  • AMOXICILLIN
  • SULFAMETHOXAZOLE
  • TRIMETHOPRIM
  • DULOXETINE
  • ETANERCEPT
  • PREDNISONE
  • INFLIXIMAB
  • ADALIMUMAB
  • LEUCOVORIN
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Special Advise

  • Let your doctor and the laboratory staff know if you are using Fotrex Combikit Tablet 24+4's since it may interfere with laboratory tests. 
  • Liver function tests are recommended since Methotrexate in Fotrex Combikit Tablet 24+4's may increase liver enzymes.
  • Your doctor may also suggest a chest x-ray and a physical examination to check for swelling of your lymph nodes (glands in your neck, armpits and groin). Any unusual swellings should also be reported to your doctor.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its own tissues), leading to joint pains and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving and swelling.

Psoriasis: It is a chronic autoimmune skin condition which causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints and dry skin.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those with a family history of psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Cancer: It is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer etc. Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation and stem cell therapy. There is no cure for cancer yet.

Have a query?

whatsapp Floating Button