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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
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Manufacturer/Marketer :

Wallace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mext F 7.5 Tablet

Mext F 7.5 Tablet belongs to the class of 'antimetabolite agents' primarily used to treat rheumatoid arthritis, psoriasis and juvenile idiopathic arthritis. Mext F 7.5 Tablet is also used to treat leukaemia (blood cancer), Non-Hodgkin's lymphoma (cancer of the lymphatic system), soft tissue and bone cancer and certain types of cancer/tumours breast, skin, head and neck, lung or uterus. Mext F 7.5 Tablet reduces the immune system's strength to treat conditions of autoimmune diseases. Arthritis is an autoimmune disease which leads to joint pain and damage.

Mext F 7.5 Tablet contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy.

Your doctor will decide the dosage based on your medical condition. In some cases, you may experience common side effects, such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach upset, stomach pain, leukopenia (decreased number of white blood cells) and soreness of mouth and lips. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are known to be allergic to Mext F 7.5 Tablet or its inactive components, please inform your doctor. Do not take Mext F 7.5 Tablet if you are pregnant or planning for pregnancy, as Mext F 7.5 Tablet causes serious congenital disabilities. Mext F 7.5 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Mext F 7.5 Tablet can cause dizziness and drowsiness; hence drive with caution. Mext F 7.5 Tablet should not be given to children below three years of age, as safety and efficacy have not been established. Avoid consuming alcohol along with Mext F 7.5 Tablet as it could lead to increased dizziness. 

Uses of Mext F 7.5 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Juvenile idiopathic arthritis, Psoriasis, and Cancer.

Directions for Use

Swallow Mext F 7.5 Tablet as a whole with a glass of water. Take Mext F 7.5 Tablet one hour after food, once every week. Take Mext F 7.5 Tablet on the same day each week. Do not crush, chew or break it.

Medicinal Benefits

Mext F 7.5 Tablet treats rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, leukaemia and cancer/tumours of the breast, skin, head and neck, lung, or uterus. It contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin B9). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It reduces pain and inflammation and slows down joint damage and disease progression over time. Hence, it is also known as a disease-modifying anti-rheumatic drug (DMARD). It also acts as an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is a water-soluble Vitamin B. It helps in the formation of red blood cells and prevents DNA changes that may lead to cancer. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Mext F 7.5 Tablet or its inactive components, please inform your doctor. Brief your medical history if you have any liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis), and active infections (including chickenpox). Mext F 7.5 Tablet is contraindicated during pregnancy since it has harmful effects on the foetus. Please get a pregnancy test done before starting Mext F 7.5 Tablet . You should get a negative pregnancy test for sure before using Mext F 7.5 Tablet . Use reliable forms of birth control if you are undergoing treatment with Mext F 7.5 Tablet to avoid pregnancy. Mext F 7.5 Tablet should not be taken by breastfeeding mothers since it is excreted into the breast milk. Mext F 7.5 Tablet can cause dizziness and drowsiness; hence drive with caution. Avoid consuming alcohol along with Mext F 7.5 Tablet as it could lead to increased dizziness. Mext F 7.5 Tablet should not be given to children below three years of age, as safety and efficacy have not been established. 

Drug-Drug Interactions

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MethotrexateEtretinate
Critical

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Etretinate with Mext F 7.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Mext F 7.5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Mext F 7.5 Tablet with cloxacillin can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cloxacillin and Mext F 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, Consult a doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Mext F 7.5 Tablet with dicloxacillin can increase the levels and effects of Mext F 7.5 Tablet. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateNitrous oxide
Severe
How does the drug interact with Mext F 7.5 Tablet:
Combine use of nitrous oxide with Mext F 7.5 Tablet may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Mext F 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.
How does the drug interact with Mext F 7.5 Tablet:
Coadministration of Mext F 7.5 Tablet with ibuprofen can increase the effect and side effects of Mext F 7.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet and ibuprofen, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Mext F 7.5 Tablet with Lansoprazole can increase the blood levels and side effects of Mext F 7.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mext F 7.5 Tablet:
Coadministration of leflunomide with Mext F 7.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Mext F 7.5 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Mext F 7.5 Tablet with amoxicillin can increase the levels and side effects of Mext F 7.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet and amoxicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Mext F 7.5 Tablet:
Co-administration of Benzylpenicillin with Mext F 7.5 Tablet may increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction, Mext F 7.5 Tablet can be taken with Benzylpenicillin if prescribed by the doctor. Consult the prescriber if you experience any symptoms such as fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body aches. Contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Mext F 7.5 Tablet:
Combine use of entecavir with Mext F 7.5 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Mext F 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants, such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Mext F 7.5 Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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FAQs

Mext F 7.5 Tablet contains Methotrexate and Folic acid. Methotrexate acts as an immunosuppressant and works by suppressing the overactive immune system that causes inflammation in the cells and tissues, thus preventing various autoimmune diseases. Folic acid is used to replace the folic acid deficiency caused by Methotrexate.

Mext F 7.5 Tablet works by suppressing the overactive immune system responsible for causing psoriasis. Mext F 7.5 Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Mext F 7.5 Tablet . Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Methotrexate in Mext F 7.5 Tablet causes leukopenia (decreased number of white blood cells) and may make you more susceptible to infections. Stay away from people with active infections. Consult your doctor if you develop any signs of infections, such as fever, sore throat, breathlessness, jaundice and unexplained bleeding or bruising.

Mext F 7.5 Tablet should be used with caution if you have a medical history of liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis) and active infections (including chickenpox).

Drug-Drug Interactions Checker List

  • DICLOFENAC
  • IBUPROFEN
  • CELECOXIB
  • MELOXICAM
  • ACETAMINOPHEN
  • HYDROCODONE
  • AMOXICILLIN
  • SULFAMETHOXAZOLE
  • TRIMETHOPRIM
  • DULOXETINE
  • ETANERCEPT
  • PREDNISONE
  • INFLIXIMAB
  • ADALIMUMAB
  • LEUCOVORIN
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Special Advise

  • Let your doctor and the laboratory staff know if you are using Mext F 7.5 Tablet since it may interfere with laboratory tests. 
  • Liver function tests are recommended since Methotrexate in Mext F 7.5 Tablet may increase liver enzymes.
  • Your doctor may also suggest a chest x-ray and a physical examination to check for swelling of your lymph nodes (glands in your neck, armpits and groin). Any unusual swellings should also be reported to your doctor.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its own tissues), leading to joint pains and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving and swelling.

Psoriasis: It is a chronic autoimmune skin condition which causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints and dry skin.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those with a family history of psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Cancer: It is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer etc. Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation and stem cell therapy. There is no cure for cancer yet.

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