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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

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Manufacturer/Marketer

Starus Pharmaceuticals

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Gabaprime-Trio Tablet

Gabaprime-Trio Tablet is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
 
Gabaprime-Trio Tablet contains Gabapentin, methylcobalamin, and nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet helps in providing relief from neuropathic pain.
 
You are advised to take Gabaprime-Trio Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Gabaprime-Trio Tablet may cause dizziness, sleepiness, tiredness, headache, nausea, vomiting, dry mouth, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet may cause sleepiness and dizziness, so drive only if you are alert. Limited data is available regarding the usage of Gabaprime-Trio Tablet in children, so please consult a doctor if you have any concerns. Avoid consuming alcohol with Gabaprime-Trio Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Gabaprime-Trio Tablet

Neuropathic pain

Directions for Use

Swallow Gabaprime-Trio Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Gabaprime-Trio Tablet contains Gabapentin (anti-convulsant), Methylcobalamin (vitamin), and Nortriptyline (tricyclic antidepressant). Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline works by increasing the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet helps in providing relief from neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Gabaprime-Trio Tablet

  • Dizziness
  • Sleepiness
  • Tiredness
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth
  • Constipation

Drug Warnings

Do not take Gabaprime-Trio Tablet if you are allergic to any of its contents. Inform your doctor if you have/had heart problems, bipolar syndrome, thyroid disorder, epilepsy, high blood pressure, diabetes, urinary retention, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet may cause sleepiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Gabaprime-Trio Tablet as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
NortriptylineIsocarboxazid
Critical

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Coadministration of Gabaprime-Trio Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Using Gabaprime-Trio Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Gabaprime-Trio Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Coadministration of Gabaprime-Trio Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Co-administration of Gabaprime-Trio Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Coadministration of Gabaprime-Trio Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Coadministration of Gabaprime-Trio Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineTranylcypromine
Critical
How does the drug interact with Gabaprime-Trio Tablet:
Coadministration of Gabaprime-Trio Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
GabapentinBuprenorphine
Severe
How does the drug interact with Gabaprime-Trio Tablet:
Co-administration of Buprenorphine and Gabaprime-Trio Tablet may cause central nervous system depression and lead to serious side effects (respiratory distress -build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Gabaprime-Trio Tablet and Buprenorphine, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinEsketamine
Severe
How does the drug interact with Gabaprime-Trio Tablet:
Combining Gabaprime-Trio Tablet with Esketamine can increase the risk of side effects.

How to manage the interaction:
Although taking Gabaprime-Trio Tablet and Esketamine together can evidently cause an interaction, it can be taken if a doctor has suggested it. Consult a doctor if you experience any symptoms such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not stop using any medications without a doctor's advice.
GabapentinPentazocine
Severe
How does the drug interact with Gabaprime-Trio Tablet:
Taking Pentazocine with Gabaprime-Trio Tablet can increase the risk of serious side effects.

How to manage the interaction:
Although taking Pentazocine and Gabaprime-Trio Tablet together can evidently cause an interaction, but it can be taken if a doctor has suggested it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well. Get optimum sleep.
  • Include cayenne pepper in your diet, as it can help in lowering neuropathic pain.
  • Try taking a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Gabaprime-Trio Tablet Substitute

Substitutes safety advice
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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ZOLPIDEM
  • DULOXETINE
  • ESCITALOPRAM
  • SERTRALINE
  • HYDROCODONE
  • ACETAMINOPHEN
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • CYCLOBENZAPRINE
  • PREGABALIN
  • TOPIRAMATE
  • ALPRAZOLAM
  • ONDANSETRON

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It occurs by chronic progressive nerve disease, infection, or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).

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