Gabaprime-Trio Tablet 10's is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
 
Gabaprime-Trio Tablet 10's contains Gabapentin, methylcobalamin, and nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet 10's helps in providing relief from neuropathic pain.
 
You are advised to take Gabaprime-Trio Tablet 10's for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Gabaprime-Trio Tablet 10's may cause dizziness, sleepiness, tiredness, headache, nausea, vomiting, dry mouth, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet 10's may cause sleepiness and dizziness, so drive only if you are alert. Limited data is available regarding the usage of Gabaprime-Trio Tablet 10's in children, so please consult a doctor if you have any concerns. Avoid consuming alcohol with Gabaprime-Trio Tablet 10's as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Gabaprime-Trio Tablet 10's contains Gabapentin (anti-convulsant), Methylcobalamin (vitamin), and Nortriptyline (tricyclic antidepressant). Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline works by increasing the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet 10's helps in providing relief from neuropathic pain.

• Dizziness
• Sleepiness
• Tiredness
• Headache
• Nausea
• Vomiting
• Dry mouth
• Constipation

Do not take Gabaprime-Trio Tablet 10's if you are allergic to any of its contents. Inform your doctor if you have/had heart problems, bipolar syndrome, thyroid disorder, epilepsy, high blood pressure, diabetes, urinary retention, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet 10's may cause sleepiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Gabaprime-Trio Tablet 10's as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions: Gabaprime-Trio Tablet 10's may interact with hypnotics (zolpidem), antidepressants (duloxetine, escitalopram, sertraline), pain killers (hydrocodone, acetaminophen), anti-histamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), anti-convulsant (pregabalin, topiramate), anti-anxiety (alprazolam), anti-emetic (ondansetron).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have heart problems, pheochromocytoma (tumour of the adrenal gland), depression, seizures, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, glaucoma, diabetes, thyroid problems, suicidal tendency, hemodialysis, kidney or liver problems.

• ZOLPIDEM
• DULOXETINE
• ESCITALOPRAM
• SERTRALINE
• HYDROCODONE
• ACETAMINOPHEN
• DIPHENHYDRAMINE
• CETIRIZINE
• CYCLOBENZAPRINE
• PREGABALIN
• TOPIRAMATE
• ALPRAZOLAM
• ONDANSETRON

• Include food rich in vitamin B and D in your diet.
• Exercising regularly helps in improving overall health and combating pain. 
• Rest well. Get optimum sleep.
• Include cayenne pepper in your diet, as it can help in lowering neuropathic pain.
• Try taking a warm bath, as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
• Acupuncture can be helpful by stimulating pressure points.
• Using essential oils for massages can help increase circulation.

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It occurs by chronic progressive nerve disease, infection, or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).