GLZ Total Tablet is a medicine that is used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin, or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination, increased thirst and increased hunger start. It can lead to serious complications like skin infection, eye problems (retinopathy), nerve damage (neuropathy), diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke.

GLZ Total Tablet contains Gliclazide, metformin and pioglitazone. Gliclazide is a 'sulfonylurea' that acts by increasing the insulin released by the pancreas. On the other hand, Metformin, which is a 'biguanide', acts by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

GLZ Total Tablet is available in oral tablet dosage form. You should take this medicine as prescribed by your doctor. You may experience side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Some patients may experience a decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately. GLZ Total Tablet should be taken with food to avoid an upset stomach. GLZ Total Tablet should be taken at the same time of the day each time for the best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. 

You should not take GLZ Total Tablet if you have diabetic ketoacidosis (excess acids in your blood). Do not take GLZ Total Tablet if you are allergic to any of its contents. Before taking GLZ Total Tablet , inform your doctor if you are taking other medicines, including prescription or non-prescription medicines, nutritional supplements, or herbal products. GLZ Total Tablet should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking GLZ Total Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). GLZ Total Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease, is or are planning to get pregnant or breastfeed. GLZ Total Tablet may cause ‘lactic acidosis’ (accumulation of lactic acid in the blood), which requires immediate medical attention. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia).

GLZ Total Tablet contains Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together GLZ Total Tablet decreases the elevated blood sugar level after the meal along with the recommended diet and exercise. GLZ Total Tablet also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot. GLZ Total Tablet also helps to reduce your chance of having a heart attack or stroke. Being a combination of two drugs, it reduces the need to take multiple pills, making it easier to remember to take the drugs.

GLZ Total Tablet may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems, as their normal functioning is required to eliminate excess lactic acid from the body.  Do not consume excess alcohol, as it increases the risk of lactic acidosis. It should be used with caution in patients with heart disease as it increases the risk of heart failure.

• Eat at regular intervals. Do not take the long gap between a meal or snack.

• Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.

• Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.

• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).

• Replace refined carbohydrates-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.

• Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.

• Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.

• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).

• Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

• Hypoglycemia

• Taste change

• Nausea (feeling sick)

• Vomiting (falling sick)

• Diarrhoea

• Stomach ache

• Respiratory infection

• Weight gain

• bone fracture

• Numbness

• Vision problems

• GLZ Total Tablet shows optimum effects when you follow healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc.
• Keep taking the drug even if your blood sugar levels are controlled. If you miss a dose, do not take a larger dose; consult your doctor for advice.
• Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of hypoglycemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
• Whenever you experience the above-mentioned symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.
• Avoid drinking alcohol while on this drug as it increases the risk of hypoglycemia (a decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
• Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar, etc.

Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition characterised by elevated blood glucose levels in the body. Insulin is in charge of the cell's utilisation of glucose. Type 2 diabetes occurs when the body's cells do not respond to insulin or, in later stages, the body does not produce enough insulin. Excessive thirst, hunger, fatigue, increased appetite, and dry mouth are all symptoms. If not properly treated, this condition may worsen over time and cause toxic effects.