Gliclazide+metformin+pioglitazone

Gliclazide+metformin+pioglitazone is a medicine that is used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin, or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination, increased thirst and increased hunger start. It can lead to serious complications like skin infection, eye problems (retinopathy), nerve damage (neuropathy), diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke.

Gliclazide+metformin+pioglitazone contains Gliclazide, metformin and pioglitazone. Gliclazide is a 'sulfonylurea' that acts by increasing the insulin released by the pancreas. On the other hand, Metformin, which is a 'biguanide', acts by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

Gliclazide+metformin+pioglitazone is available in oral tablet dosage form. You should take this medicine as prescribed by your doctor. You may experience side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Some patients may experience a decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately. Gliclazide+metformin+pioglitazone should be taken with food to avoid an upset stomach. Gliclazide+metformin+pioglitazone should be taken at the same time of the day each time for the best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. 

You should not take Gliclazide+metformin+pioglitazone if you have diabetic ketoacidosis (excess acids in your blood). Do not take Gliclazide+metformin+pioglitazone if you are allergic to any of its contents. Before taking Gliclazide+metformin+pioglitazone, inform your doctor if you are taking other medicines, including prescription or non-prescription medicines, nutritional supplements, or herbal products. Gliclazide+metformin+pioglitazone should not be stopped even if you feel better, without consulting your doctor as your sugar level keeps changing. If you stop taking Gliclazide+metformin+pioglitazone abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Gliclazide+metformin+pioglitazone should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease, is or are planning to get pregnant or breastfeed. Gliclazide+metformin+pioglitazone may cause ‘lactic acidosis’ (accumulation of lactic acid in the blood), which requires immediate medical attention. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia).

Type 2 Diabetes Mellitus

Gliclazide+metformin+pioglitazone contains Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together Gliclazide+metformin+pioglitazone decreases the elevated blood sugar level after the meal along with the recommended diet and exercise. Gliclazide+metformin+pioglitazone also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot. Gliclazide+metformin+pioglitazone also helps to reduce your chance of having a heart attack or stroke. Being a combination of two drugs, it reduces the need to take multiple pills, making it easier to remember to take the drugs.

Tablets are swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. Take the dose your doctor prescribes at a fixed time every day. Take this medicine with food to prevent hypoglycemia.

Store in a cool and dry place away from sunlight

• Hypoglycemia

• Taste change

• Nausea (feeling sick)

• Vomiting (falling sick)

• Diarrhoea

• Stomach ache

• Respiratory infection

• Weight gain

• bone fracture

• Numbness

• Vision problems