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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

PIOGLITAZONE-15MG

Manufacturer/Marketer :

Lincoln Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About GP 15 Tablet

GP 15 Tablet is an anti-diabetic medicine belonging to the class of thiazolidinedione (TZD), also called 'glitazones', used to treat type 2 (non-insulin-dependent) diabetes mellitus. Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This is diabetes that usually develops in adulthood.

GP 15 Tablet contains Pioglitazone which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces. Your doctor will check whether Pioglitazone is working 3-6 months after you start taking it. 

GP 15 Tablet should be taken with food or an empty stomach. However, it should be taken at the same time of the day each time for the best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. The most common side effect of GP 15 Tablet is upper respiratory tract infection, headache, sinusitis, myalgia (muscle pain), and pharyngitis. Most of these side effects of GP 15 Tablet do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

GP 15 Tablet should not be stopped even if you feel better without consulting your doctor as sugar levels change. If you stop taking GP 15 Tablet suddenly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney damage (nephropathy) and nerve damage (neuropathy). GP 15 Tablet should not be taken if you have type 1 diabetes mellitus, if you are hypersensitive (allergic) to GP 15 Tablet or any of the other ingredients of GP 15 Tablet , have heart failure or have had heart failure in the past, diabetic ketoacidosis (a complication of diabetes causing rapid weight loss, nausea or vomiting), severe kidney or liver disease, bladder cancer. Please inform your doctor if you have any heart disease, are or planning to get pregnant or breastfeeding. The safety and efficacy of GP 15 Tablet in children under 18 years have not been established, so it should not be given to them.

Uses of GP 15 Tablet

Type 2 diabetes mellitus

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

GP 15 Tablet is an antidiabetic drug (thiazolidinedione/glitazones) used along with a proper diet and exercise to control high blood sugar (hyperglycaemia) in patients with type 2 diabetes. GP 15 Tablet works by helping to restore your body's appropriate response to insulin, thereby lowering your blood sugar.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Fluid retention (oedema) may occur and can lead to congestive heart failure so, a combination of use with insulin and use in heart failure may increase the risk in patients taking GP 15 Tablet . You should not take GP 15 Tablet if you have kidney disease, as measured by a blood test. GP 15 Tablet , when used with or without insulin, $ name tends to lower the blood sugar level. So, the doctor may lower the dose of insulin. Increased fractures may be reported in some women taking GP 15 Tablet . Patients with bladder cancer and macular oedema (fluid build-up in the macula part of the retina of the eye) should consult the doctor before using GP 15 Tablet .

Drug-Drug Interactions

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GlimepiridePromazine
Severe

Drug-Drug Interactions

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How does the drug interact with GP 15 Tablet:
Co-administration of Ofloxacin and GP 15 Tablet can sometimes have an effect on blood glucose levels.

How to manage the interaction:
Although combining Ofloxacin and GP 15 Tablet can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose level. Do not discontinue any medications without consulting a doctor.
GlimepiridePromazine
Severe
How does the drug interact with GP 15 Tablet:
When GP 15 Tablet is taken with Promazine may interfere with blood glucose control and reduce the effectiveness of GP 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between GP 15 Tablet and Promazine, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much urine you're producing. If you notice any of these signs - very high or very low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with GP 15 Tablet:
Taking GP 15 Tablet with Paroxetine may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, GP 15 Tablet can be taken with paroxetine if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP 15 Tablet:
Co-administration of Leflunomide may increase the blood levels and effects of GP 15 Tablet.

How to manage the interaction:
Although there is a possible interaction, GP 15 Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor if your condition changes or you experience increased side effects. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP 15 Tablet:
Taking GP 15 Tablet with Vilazodone may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, GP 15 Tablet can be taken with Vilazodone if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP 15 Tablet:
Co-administration of Sparfloxacin with GP 15 Tablet can affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, GP 15 Tablet can be taken with Sparfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat (or) symptoms of high blood sugar like increased thirst, increased hunger, and increased urination. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideTrovafloxacin
Severe
How does the drug interact with GP 15 Tablet:
When GP 15 Tablet is taken with Trovafloxacin, it can affect blood glucose levels either hypoglycemia or hyperglycemia.

How to manage the interaction:
Taking GP 15 Tablet with Trovafloxacin together can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to be aware of symptoms like increased urination and thirst, and to contact your doctor if you experience any concerning symptoms. Your doctor may be able to suggest alternative medications that don't interact with your diabetes treatment. Do not stop using any medications without a doctor's advice.
How does the drug interact with GP 15 Tablet:
When GP 15 Tablet is taken with Nalidixic acid, can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
There may be a possibility of interaction between GP 15 Tablet and Nalidixic acid, but it can be taken if prescribed by a doctor. It's important to monitor your blood sugar levels closely. If you experience symptoms like kidney problems, low or high blood sugar, or other concerning symptoms, contact a doctor right away. They may be able to suggest alternative medications that won't interact with a diabetes treatment. Do not discontinue any medications without consulting a doctor.
How does the drug interact with GP 15 Tablet:
Co-administration of GP 15 Tablet with Isoniazid may interfere with blood glucose control and reduce the effectiveness of GP 15 Tablet.

How to manage the interaction:
Although there is a possible interaction, GP 15 Tablet can be taken with Isoniazid if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP 15 Tablet:
Co-administration of GP 15 Tablet with Levofloxacin can affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Co-administration of Levofloxacin with GP 15 Tablet can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
  • Eat at regular interval. Do not take the long gap between a meal or snack.
  • Monitor your blood sugar level regularly especially when there are a lot of fluctuations.
  • Invest at least 150 min of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates containing foods with whole grain foods and increase intake of fruits and veggies and other fibre enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in the food like chips, crisps, pastries, biscuits and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga or meditation to control stress-related to blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).
  • Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Author Details

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Drug-Diseases Interactions

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PIOGLITAZONE-15MGHypertensive heart and renal disease
Severe
PIOGLITAZONE-15MGUnspecified kidney failure
Severe

Drug-Diseases Interactions

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PIOGLITAZONE-15MGHypertensive heart and renal disease
Severe
How does the disease interact with GP 15 Tablet:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
PIOGLITAZONE-15MGUnspecified kidney failure
Severe
How does the disease interact with GP 15 Tablet:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.

How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
PIOGLITAZONE-15MGOther disorders of adrenal gland
Moderate
How does the disease interact with GP 15 Tablet:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.

How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
PIOGLITAZONE-15MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with GP 15 Tablet:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.

How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
PIOGLITAZONE-15MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with GP 15 Tablet:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.

How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.

FAQs

Type-2 diabetes generally does not affect healthy children and teens, but it may affect children who are obese, which is also known as Childhood Obesity.

Hypoglycemia refers to low blood sugar levels, and it is one of the side effects of GP 15 Tablet . Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. It is important to monitor blood sugar levels regularly.

If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact doctor as it can be a condition of type 2 diabetes.

In case you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.

Yes, Metformin and Pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels. Metformin and pioglitazone are used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections.

If you have or have ever had urinary bladder cancer, diabetic eye disease (retinopathy), or kidney or liver disease, avoid use of GP 15 Tablet . If it is urgent consult with the doctor.

Drug-Drug Interactions Checker List

  • GEMFIBROZIL
  • RIFAMPICIN

Special Advise

  • Keep taking the drug even if you think your blood sugar levels are under control. If you miss a dose, do not take a larger dose. Consult your treating physician for advice. 
  • Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of symptoms of hypoglycaemia which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels. 
  • Before the doctor prescribes this medicine, it is always better that your physician knows about any underlying conditions like kidney or liver disease, prior heart attack, alcohol intake, etc.
  • Avoid drinking alcohol while on this drug as it increases the risk of hypoglycaemia (decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
  • Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar etc.

Disease/Condition Glossary

Type 2 diabetes is a chronic or lifelong disease that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin or resist insulin action. Middle-aged or older are most likely to suffer from type 2 diabetes, also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while weight loss may be observed in rare cases. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.

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