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Written By Divya L , PharmaD
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Grandem Syrup

Grandem Syrup belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer, etc. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Grandem Syrup contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron' that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Grandem Syrup include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping , and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Grandem Syrup. Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions , and low levels of potassium and magnesium in the blood before starting Grandem Syrup. Grandem Syrup may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Grandem Syrup if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Grandem Syrup as it could lead to increased drowsiness. 

Uses of Grandem Syrup

Nausea and vomiting.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water, do not chew, crush or break it.Syrup/Liquid: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Grandem Syrup contains an anti-emetic drug, 'Granisetron' that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. Grandem Syrup works by blocking the activity of serotonin in the brain and preventing post-operative nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Grandem Syrup

  • Diarrhoea
  • Constipation
  • Stomach pain
  • Weakness
  • Headache
  • Fever
  • Dizziness
  • Drowsiness
  • Trouble sleeping
  • Anxiety

Drug Warnings

Grandem Syrup may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Grandem Syrup. Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Grandem Syrup. Grandem Syrup may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Grandem Syrup is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
GranisetronSaquinavir
Critical

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem Syrup 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem Syrup 10 ml:
When Grandem Syrup 10 ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronDronedarone
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronThioridazine
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronZiprasidone
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronCisapride
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSparfloxacin
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronPimozide
Critical
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDofetilide
Severe
How does the drug interact with Grandem Syrup 10 ml:
Taking Grandem Syrup 10 ml with dofetilide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Grandem Syrup 10 ml with Dofetilide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
GranisetronSotalol
Severe
How does the drug interact with Grandem Syrup 10 ml:
Taking Sotalol and Grandem Syrup 10 ml can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Grandem Syrup 10 ml, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Grandem Syrup Substitute

Substitutes safety advice
  • Grandem MD Tablet 10's

    by AYUR

    10.35per tablet
  • Graniforce -MD Tablet 10's

    by Others

    9.23per tablet
  • Grandem-1 Tablet 10's

    by AYUR

    9.45per tablet
  • Graniforce Syrup 10 ml

    by Others

    5.31per tablet
  • Granicip 1 DT Tablet 4's

    by Others

    24.42per tablet

Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Grandem Syrup contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem Syrup relieves from post-operative nausea and vomiting symptoms.

Grandem Syrup may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Grandem Syrup should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Take Grandem Syrup as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DULOXETINE
  • AMIODARONE
  • QUINIDINE
  • RITONAVIR
  • ERYTHROMYCIN

Special Advise

Let your doctor know that you are taking Grandem Syrup if you are undergoing any medical tests.

Disease/Condition Glossary

Nausea is defined as stomach discomfort and the sensation of an urge to vomit. It is a precursor to vomiting. It is not a painful symptom but can cause discomfort in the chest, upper abdomen or back of the throat. Nausea can be triggered by various factors like motion from a car and plane, taking pills on an empty stomach, eating too much or too little and drinking excessive amounts of alcohol.

Vomiting or throwing up is the forcible voluntary or involuntary emptying of the stomach contents through the mouth. Vomiting can also occur without having any underlying diseases in conditions like pregnancy, hangover, overeating and motion sickness. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer or bulimia (eating disorder).

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