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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Herduo Tablet

Herduo Tablet is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Herduo Tablet is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Herduo Tablet contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Herduo Tablet may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Herduo Tablet should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Herduo Tablet should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Herduo Tablet . Herduo Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Herduo Tablet

Breast Cancer.

Directions for Use

Take Herduo Tablet as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Herduo Tablet contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Herduo Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Drug Warnings

Herduo Tablet should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Herduo Tablet may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Herduo Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Herduo Tablet should be given to children only if prescribed by the paediatrician. Herduo Tablet is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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LapatinibFosphenytoin
Severe
LapatinibLoperamide
Severe

Drug-Drug Interactions

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LapatinibFosphenytoin
Severe
How does the drug interact with Herduo Tablet:
When Herduo Tablet is taken with Fosphenytoin, it can cause the body to process Herduo Tablet faster. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Fosphenytoin and Herduo Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
LapatinibLoperamide
Severe
How does the drug interact with Herduo Tablet:
When taken in combination Herduo Tablet may significantly raise the loperamide levels in the blood. This can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking loperamide with Herduo Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LapatinibNilotinib
Severe
How does the drug interact with Herduo Tablet:
Combining Herduo Tablet and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Herduo Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibGatifloxacin
Severe
How does the drug interact with Herduo Tablet:
Taking Gatifloxacin and Herduo Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Herduo Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LapatinibPosaconazole
Severe
How does the drug interact with Herduo Tablet:
Taking Herduo Tablet with posaconazole can increase the levels of Herduo Tablet in the blood, which can lead to an increased risk of side effects such as diarrhea, liver problems, and heart problems.

How to manage the interaction:
Although using Posaconazole and Herduo Tablet together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
LapatinibCeritinib
Severe
How does the drug interact with Herduo Tablet:
Taking Herduo Tablet with ceritinib may significantly increase the blood levels of Herduo Tablet. This can make you more likely to develop side effects such as diarrhea and liver problems.

How to manage the interaction:
Co-administration of Ceritinib with Herduo Tablet can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LapatinibItraconazole
Severe
How does the drug interact with Herduo Tablet:
Using Herduo Tablet together with itraconazole may significantly increase the blood levels of Herduo Tablet.

How to manage the interaction:
Herduo Tablet and itraconazole may interact, but if a doctor prescribes them, you can still use them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and yellowing of the skin or eyes, diarrhoea, dizziness, lightheadedness, fainting, shortness of breath, or rapid or pounding heartbeats, seek medical attention. Never discontinue taking a medication without consulting a doctor.
LapatinibMorphine
Severe
How does the drug interact with Herduo Tablet:
Coadministration of Morphine with Herduo Tablet may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Herduo Tablet with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed and motor coordination, headaches, irritation, confusion, oedema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LapatinibPazopanib
Severe
How does the drug interact with Herduo Tablet:
Taking Pazopanib with Herduo Tablet may significantly increase the blood levels of pazopanib. This can make you more likely to develop serious side effects such as liver problems, irregular heart rhythm, bleeding and high blood pressure,

How to manage the interaction:
Taking Pazopanib with Herduo Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, fast or pounding heartbeats, chest pain or tightness, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, and difficulty speaking. Do not stop using any medications without a doctor's advice.
LapatinibEnzalutamide
Severe
How does the drug interact with Herduo Tablet:
When Herduo Tablet is taken with Enzalutamide, this could reduce the effects of Herduo Tablet and its blood levels. Additionally, taking these medications together may enhance enzalutamide's effects and blood levels.

How to manage the interaction:
Co-administration of Enzalutamide with Herduo Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like Seizures, exhaustion, fatigue, constipation, discomfort in the muscles or bones, hot flushes, swelling, tingling or prickling, headaches, dizziness, sleeplessness, anxiety, and increased blood pressure, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Herduo Tablet Substitute

Substitutes safety advice
  • Tykerb 250 mg Tablet 30's

    by AYUR

    300.30per tablet
  • Combinib 250Mg Tablet 30'S

    by AYUR

    224.90per tablet
  • DU Knib 250mg Tablet

    by Others

    221.40per tablet
  • Etibo 250 mg Tablet 30's

    by Others

    270.60per tablet
  • Bretolap 250 mg Tablet 30's

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    163.73per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Herduo Tablet contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.

Inform your doctor whether you have received any other breast cancer treatment. Herduo Tablet may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Herduo Tablet .

Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Herduo Tablet . Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • KETOCONAZOLE
  • RITONAVIR
  • VERAMAPIL
  • DILTIAZEM
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • ST JOHN'S WORT
  • INDINAVIR
  • EFAVIRENZ
  • ITRACONAZOLE

Special Advise

  • Avoid intercourse while on treatment with Herduo Tablet .
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

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