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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

LAPATINIB-250MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Tykerb 250mg Tablet 30's

Tykerb 250mg Tablet 30's is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Tykerb 250mg Tablet 30's is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Tykerb 250mg Tablet 30's contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Tykerb 250mg Tablet 30's may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Tykerb 250mg Tablet 30's should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Tykerb 250mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Tykerb 250mg Tablet 30's. Tykerb 250mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Tykerb 250mg Tablet 30's

Breast Cancer.

Directions for Use

Take Tykerb 250mg Tablet 30's as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Tykerb 250mg Tablet 30's contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tykerb 250mg Tablet 30's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Dry skin
  • Hair loss
  • Tiredness
  • Weakness
  • Headache
  • Fatigue

Drug Warnings

Tykerb 250mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Tykerb 250mg Tablet 30's may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Tykerb 250mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Tykerb 250mg Tablet 30's should be given to children only if prescribed by the paediatrician. Tykerb 250mg Tablet 30's is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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LapatinibClozapine
Severe
LapatinibDisopyramide
Severe

Drug-Drug Interactions

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LapatinibClozapine
Severe
How does the drug interact with Tykerb 250mg Tablet:
When Clozapine is taken with Tykerb 250mg Tablet, can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Taking Clozapine with Tykerb 250mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. You may also experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, sudden dizziness, feeling lightheaded, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LapatinibDisopyramide
Severe
How does the drug interact with Tykerb 250mg Tablet:
The combined use of Tykerb 250mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Tykerb 250mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibPosaconazole
Severe
How does the drug interact with Tykerb 250mg Tablet:
Taking Tykerb 250mg Tablet with posaconazole can increase the levels of Tykerb 250mg Tablet in the blood, which can lead to an increased risk of side effects such as diarrhea, liver problems, and heart problems.

How to manage the interaction:
Although using Posaconazole and Tykerb 250mg Tablet together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
LapatinibMorphine
Severe
How does the drug interact with Tykerb 250mg Tablet:
Coadministration of Morphine with Tykerb 250mg Tablet may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Tykerb 250mg Tablet with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed and motor coordination, headaches, irritation, confusion, oedema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LapatinibClarithromycin
Severe
How does the drug interact with Tykerb 250mg Tablet:
Taking clarithromycin with Tykerb 250mg Tablet may increase the blood levels of Tykerb 250mg Tablet. This might make you more likely to develop side effects such as diarrhea, liver damage, and heart problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Tykerb 250mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with Tykerb 250mg Tablet. Do not stop using any medications without a doctor's advice.
LapatinibGatifloxacin
Severe
How does the drug interact with Tykerb 250mg Tablet:
Taking Gatifloxacin and Tykerb 250mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Tykerb 250mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LapatinibKetoconazole
Severe
How does the drug interact with Tykerb 250mg Tablet:
Coadministration of Tykerb 250mg Tablet and ketoconazole may greatly increase Tykerb 250mg Tablet blood levels. This can increase the risk for side effects (diarrhea, liver damage, and heart problems like decreased heartbeat and irregular heartbeat).

How to manage the interaction:
Although taking Ketoconazole and Tykerb 250mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, sudden dizziness, lightheadedness, fainting; shortness of breath, or rapid or pounding heartbeats. Do not discontinue any medication without consulting a doctor.
LapatinibSotalol
Severe
How does the drug interact with Tykerb 250mg Tablet:
Taking Sotalol and Tykerb 250mg Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Tykerb 250mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
LapatinibFosphenytoin
Severe
How does the drug interact with Tykerb 250mg Tablet:
When Tykerb 250mg Tablet is taken with Fosphenytoin, it can cause the body to process Tykerb 250mg Tablet faster. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Fosphenytoin and Tykerb 250mg Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
LapatinibAmiodarone
Severe
How does the drug interact with Tykerb 250mg Tablet:
Coadministration of Amiodarone together with Tykerb 250mg Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Tykerb 250mg Tablet interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Tykerb 250mg Tablet 30's Substitute

Substitutes safety advice
  • Herduo Tablet 30's

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  • Libset Tablet 30's

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  • TYKERB 250MG TABLET

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • KETOCONAZOLE
  • RITONAVIR
  • VERAMAPIL
  • DILTIAZEM
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • ST JOHN'S WORT
  • INDINAVIR
  • EFAVIRENZ
  • ITRACONAZOLE

Special Advise

  • Avoid intercourse while on treatment with Tykerb 250mg Tablet 30's.
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

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