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  3. Indease 400mg Capsule

Indease 400mg Capsule, Pack of 1 Capsule
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

INDINAVIR-400MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Indease 400mg Capsule

Indease 400mg Capsule belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Indease 400mg Capsule does not cure HIV infection. It reduces the viral load in the body and keeps it at a low level. Taking Indease 400mg Capsule decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections.
 
Indease 400mg Capsule contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection.
 
In some cases, Indease 400mg Capsule may cause side effects such as nausea, headache, loss of appetite, and weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.
 
Consult the doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding whilst on treatment with Indease 400mg Capsule. Tell the doctor about your new or worsening symptoms during treatment with Indease 400mg Capsule. Keep your doctor informed about your health condition and medications to prevent any side effects/interactions.

Uses of Indease 400mg Capsule

HIV infection

Directions for Use

Swallow Indease 400mg Capsule as a whole with water or other beverages such as skim or non-fat milk, juice, coffee, or tea; do not chew or crush it. Take Indease 400mg Capsule on an empty stomach, i.e., 1 hour before or 2 hours after meals. If you experience stomach upset, take it with a light meal such as cornflakes or dry toast.

Medicinal Benefits

Indease 400mg Capsule belongs to a group of antiretroviral medicines called protease inhibitors used to treat HIV infection. Indease 400mg Capsule contains Indinavir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 (T) cells, a type of white blood cell that helps the body fight infection. Indease 400mg Capsule reduces the viral load in the body and keeps it at a low level. Taking Indease 400mg Capsule decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections. Indease 400mg Capsule may also be used in combination with other medicines to treat people exposed to HIV infection after accidental contact with HIV-contaminated blood, body fluids, or tissues.

Storage

Store in a cool and dry place away from sunlight
Side effects of Indease 400mg Capsule
  • Stay hydrated by drinking at least 8 glasses of water daily.
  • Limit sodium intake by reducing salty foods.
  • Moderate animal protein by limiting red meat, poultry, and fish.
  • Incorporate calcium-rich plant-based foods like leafy greens and fortified foods.
  • Limit oxalate-rich foods like spinach, rhubarb, beets, chocolate, nuts, and certain berries.
  • Eat citrus fruits like lemons and oranges for citric acid benefits.
  • Exercise regularly with moderate physical activity.
  • Maintain a healthy weight to reduce stone risk.
  • Monitor urine output by tracking volume and color.
  • Keep a food diary to track kidney stone-friendly diet.
  • Consult a healthcare professional to discuss kidney stone type and management plan.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Stay hydrated by drinking at least 8 glasses of water daily.
  • Limit sodium intake by reducing salty foods.
  • Moderate animal protein by limiting red meat, poultry, and fish.
  • Incorporate calcium-rich plant-based foods like leafy greens and fortified foods.
  • Limit oxalate-rich foods like spinach, rhubarb, beets, chocolate, nuts, and certain berries.
  • Eat citrus fruits like lemons and oranges for citric acid benefits.
  • Exercise regularly with moderate physical activity.
  • Maintain a healthy weight to reduce stone risk.
  • Monitor urine output by tracking volume and color.
  • Keep a food diary to track kidney stone-friendly diet.
  • Consult a healthcare professional to discuss kidney stone type and management plan.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Drug Warnings

Do not take Indease 400mg Capsule if you are allergic to any of its components. Inform your doctor if you have liver problems, especially if you have mild/moderate liver disease caused by cirrhosis, kidney problems, diabetes, haemophilia (a disorder in which the blood does not clot properly), high cholesterol and if you are taking cholesterol-lowering medicines known as statins. Let the doctor know if you are taking prescription/non-prescription medicines, including herbal products or dietary supplements.

Drug-Drug Interactions

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IndinavirSilodosin
Critical
IndinavirMidazolam
Critical

Drug-Drug Interactions

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IndinavirSilodosin
Critical
How does the drug interact with Indease 400mg Capsule:
Coadministration of Silodosin with Indease 400mg Capsule may significantly increase the blood levels and effects of Silodosin, this may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position.

How to manage the interaction:
Taking Silodosin with Indease 400mg Capsule together is not recommended s it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
IndinavirMidazolam
Critical
How does the drug interact with Indease 400mg Capsule:
Indease 400mg Capsule and Midazolam co-administration may considerably enhance Midazolam blood levels and effects.

How to manage the interaction:
Although taking Indease 400mg Capsule and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
IndinavirNimodipine
Critical
How does the drug interact with Indease 400mg Capsule:
When Nimodipine is taken with Indease 400mg Capsule, it can increase the risk of side effects.

How to manage the interaction:
Taking Nimodipine with Indease 400mg Capsule is not recommended, as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor if you experience irregular heart rhythm, swelling. Do not discontinue any medications without a doctor's advice.
IndinavirRifampicin
Critical
How does the drug interact with Indease 400mg Capsule:
When Indease 400mg Capsule is taken with Rifampicin, it can reduce the blood levels and effects of Indease 400mg Capsule.

How to manage the interaction:
Although there is an interaction between Indease 400mg Capsule and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IndinavirLurasidone
Critical
How does the drug interact with Indease 400mg Capsule:
Using Lurasidone together with Indease 400mg Capsule may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Indease 400mg Capsule may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
IndinavirSimvastatin
Critical
How does the drug interact with Indease 400mg Capsule:
Combining Indease 400mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Indease 400mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
IndinavirSildenafil
Critical
How does the drug interact with Indease 400mg Capsule:
Coadministration of Indease 400mg Capsule and Sildenafil can increase the blood levels and side effects of sildenafil.

How to manage the interaction:
Taking Indease 400mg Capsule and Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
IndinavirAmiodarone
Critical
How does the drug interact with Indease 400mg Capsule:
The combination of Amiodarone and Indease 400mg Capsule may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amiodarone and Indease 400mg Capsule interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
IndinavirAlprazolam
Critical
How does the drug interact with Indease 400mg Capsule:
The combination of Alprazolam and Indease 400mg Capsule may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Indease 400mg Capsule, it can be used if prescribed by a doctor. Consult a doctor if you have drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
IndinavirTicagrelor
Critical
How does the drug interact with Indease 400mg Capsule:
Using ticagrelor together with Indease 400mg Capsule can cause risk of bleeding.

How to manage the interaction:
Taking Ticagrelor with Indease 400mg Capsule is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items that can have body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Indease 400mg Capsule Substitute

Substitutes safety advice

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • MIDAZOLAM
  • TRIAZOLAM
  • ALPRAZOLAM
  • PIMOZIDE
  • CISAPRIDE
  • AMIODARONE
  • ASTEMIZOLE
  • SILDENAFIL
  • ALFUZOSIN
  • RIFAMPIN
  • LOVASTATIN
  • SIMVASTATIN
  • ROSUVASTATIN
  • ATORVASTATIN
  • ATAZANAVIR
  • St John's wort

Special Advise

  • Avoid taking Indease 400mg Capsule at the same time as meals that are high in calories, protein, or fat.
  • Drink at least 1.5 litres of fluids (preferably water) throughout the day, every day. 

Disease/Condition Glossary

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help fight infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. It spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating it with antiretroviral drugs. 

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