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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

ISAVUCONAZOLE-200MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Isuvaz 200 mg Infusion

Isuvaz 200 mg Infusion belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis (in patients for whom Amphotericin B is not suitable). Invasive aspergillosis is an infection caused by Aspergillus fungus. It occurs by breathing and spreads from the lungs to the kidneys, brain, heart or skin. Mucormycosis is a rare but serious fungal infection of the skin or respiratory system that occurs in people with weakened immune systems.

Isuvaz 200 mg Infusion contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.

Isuvaz 200 mg Infusion will be administered by a healthcare professional; do not self-administer. Some people may experience headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of Isuvaz 200 mg Infusion do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to Isuvaz 200 mg Infusion or any other medicines, please tell your doctor. Isuvaz 200 mg Infusion is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Isuvaz 200 mg Infusion. Avoid breastfeeding while taking Isuvaz 200 mg Infusion. Drive only if you are alert after taking Isuvaz 200 mg Infusion as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Isuvaz 200 mg Infusion as it may increase the risk of liver damage.

Uses of Isuvaz 200 mg Infusion

Invasive aspergillosis and Mucormycosis

Directions for Use

Isuvaz 200 mg Infusion will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Isuvaz 200 mg Infusion contains Isavuconazole, a broad-spectrum antifungal that is effective against a wide variety of microorganisms. It inhibits the synthesis of fungal cell membranes that are essential for their survival. Thereby, Isuvaz 200 mg Infusion kills or stops the growth of the fungus.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Isuvaz 200 mg Infusion or any other medicines, please tell your doctor. Isuvaz 200 mg Infusion is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Isuvaz 200 mg Infusion. Avoid breastfeeding while taking Isuvaz 200 mg Infusion. Drive only if you are alert after taking Isuvaz 200 mg Infusion as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Isuvaz 200 mg Infusion as it may increase the risk of liver damage. If you experience severe blistering of the eyes, mouth, skin or genitals, seek immediate medical help.

Drug-Drug Interactions

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IsavuconazoleFosamprenavir
Critical

Drug-Drug Interactions

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How does the drug interact with Isuvaz 200 mg Infusion:
When Isuvaz 200 mg Infusion is taken with Posaconazole, it can increase the levels of Isuvaz 200 mg Infusion in the blood.

How to manage the interaction:
Although there is an interaction between Isuvaz 200 mg Infusion and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleFosamprenavir
Critical
How does the drug interact with Isuvaz 200 mg Infusion:
When Fosamprenavir is taken with Isuvaz 200 mg Infusion, it can increase the risk of side effects like liver damage.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Fosamprenavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
How does the drug interact with Isuvaz 200 mg Infusion:
Taking Isuvaz 200 mg Infusion with Ritonavir may significantly increase the blood levels of Isuvaz 200 mg Infusion, which may increase the risk of side effects.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsavuconazoleSaquinavir
Critical
How does the drug interact with Isuvaz 200 mg Infusion:
When Isuvaz 200 mg Infusion is taken with Saquinavir, it can increase the risk of liver damage.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Saquinavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
How does the drug interact with Isuvaz 200 mg Infusion:
Co-administration of phenytoin and Isuvaz 200 mg Infusion may significantly reduce the blood levels of Isuvaz 200 mg Infusion, which may make Isuvaz 200 mg Infusion less effective in treating your condition.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Isuvaz 200 mg Infusion:
The blood levels and effects of Isuvaz 200 mg Infusion may be significantly enhanced by taking Itraconazole along with it.

How to manage the interaction:
Co-administration of Isuvaz 200 mg Infusion and Itraconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Isuvaz 200 mg Infusion:
When Isuvaz 200 mg Infusion is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Isuvaz 200 mg Infusion:
Taking Isuvaz 200 mg Infusion with primidone may decrease the blood levels of Isuvaz 200 mg Infusion and reduce its effectiveness.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Isuvaz 200 mg Infusion:
Taking ceritinib with Isuvaz 200 mg Infusion may significantly increase the blood levels of Isuvaz 200 mg Infusion.

How to manage the interaction:
Taking Isuvaz 200 mg Infusion with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Isuvaz 200 mg Infusion:
When Isuvaz 200 mg Infusion is taken with Clarithromycin, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clarithromycin and Isuvaz 200 mg Infusion can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to avoid areas with a lot of dust like excavation or construction sites. If you can’t avoid it, wear an N95 mask while going to such places.
  • Clean skin injuries with soap and water, especially if they have been exposed to dust or soil to decrease the chances of developing a skin infection.
  • Bandage all wounds until they heal to prevent fungal infections.
  • Wash your hands frequently and keep your hands clean to prevent the spread of germs.
  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt, long pants and a mask while doing outdoor activities such as yard work, gardening or vising wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Isuvaz 200 mg Infusion contains Isavuconazole which works by inhibiting the synthesis of fungal cell membranes which are essential for their survival. Thereby, Isuvaz 200 mg Infusion kills or inhibits the growth of the fungus.

Mucormycosis is not contagious. Mucormycosis is a severe fungal infection of the skin or respiratory system that occurs in people with a weakened immune system.

Isuvaz 200 mg Infusion may cause headaches as a common side effect. However, if the condition persists or worsens, please consult a doctor.

You are not recommended to take Isuvaz 200 mg Infusion with ketoconazole as it may increase the levels of Isuvaz 200 mg Infusion in your blood and increase the risk of side effects such as diarrhoea, vomiting, nausea or liver problems. However, please consult your doctor before taking Isuvaz 200 mg Infusion with other medicines.

Isuvaz 200 mg Infusion should be used with caution in patients with liver problems as Isuvaz 200 mg Infusion may increase liver enzymes. Thus, monitoring of liver enzymes is advised while taking Isuvaz 200 mg Infusion. However, you are recommended to inform your doctor if you have any liver problems.

Drug-Drug Interactions Checker List

  • RITONAVIR
  • EFAVIRENZ
  • ETRAVIRINE
  • RIFABUTIN
  • RIFAMPICIN
  • PREDNISONE
  • TACROLIMUS
  • SIROLIMUS
  • CICLOSPORIN
  • PIOGLITAZONE
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • PHENYTOIN
  • KETOCONAZOLE
  • METFORMIN

Special Advise

Regular blood tests are recommended while taking Isuvaz 200 mg Infusion to monitor liver functioning.

Disease/Condition Glossary

Invasive aspergillosis: It is an infection carried on by the fungus Aspergillus. When the infection moves from the lungs to the kidneys, brain, heart, or skin, it manifests itself. It mostly affects people whose immune systems have been compromised by chemotherapy or other illnesses like cancer or AIDS. The signs include coughing, fever, chest pain, and shortness of breath (sometimes with blood).

Mucormycosis: People with compromised immune systems are more susceptible to this uncommon but severe fungal infection of the skin or respiratory system. It can lead to death if not treated. Nasal congestion, headaches, coughs, fevers, and pain in the sinuses are some of the signs of respiratory infections. The signs of a skin infection include blisters or ulcers, redness, swelling, tenderness, and blackened skin tissue.

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