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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS

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Oral

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About Itratuf 200 Capsules

Itratuf 200 Capsules belongs to a class of drugs called antifungals used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. Fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

Itratuf 200 Capsules contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, causes the main components of fungal cells to leak out and kill fungi and clear the fungal infection.

Take Itratuf 200 Capsules as prescribed. Your doctor will advise you on how often you take Itratuf 200 Capsules based on your medical condition. Some people may experience nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Most of these side effects of Itratuf 200 Capsules do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Itratuf 200 Capsules or any other medicines, please tell your doctor. Itratuf 200 Capsules is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy or a nursing mother, it is advised to consult a doctor before using Itratuf 200 Capsules . Do not take Itratuf 200 Capsules if you have or had heart failure as it may cause severe life-threatening adverse effects. If you have kidney, liver, heart or lung problems, inform your doctor before taking Itratuf 200 Capsules . Avoid taking fentanyl (a strong opioid narcotic medicine) with Itratuf 200 Capsules as it may cause severe breathing problems and can even lead to death. If you experience numbness or tingling in your hands or feet, stop taking Itratuf 200 Capsules and consult your doctor immediately as they might be symptoms of nerve damage.

Uses of Itratuf 200 Capsules

Fungal infections

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Directions for Use

Tablet: Take it with food to avoid stomach upset or as advised by the doctor. Swallow the whole tablet with a glass of water. Do not break, crush or chew it. If you are taking any stomach acid suppressor or have achlorhydria (stomach does not produce hydrochloric acid), take Itratuf 200 Capsules with cola. Oral suspension: Shake the bottle well before use and take it on an empty stomach at least 1 or 2 hours before meals as prescribed by your doctor with a measuring cup or spoon provided.

Key Benefits

Itratuf 200 Capsules is an antifungal used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Itratuf 200 Capsules inhibits the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes causing the main components of fungal cells to leak out. Thus, kills fungi and clears the fungal infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Itratuf 200 Capsules
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
  • Stay hydrated by drinking plenty of water.
  • Exercise regularly and maintain healthy weight.
  • Manage stress.
  • Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
  • Avoid smoking and limit intake of caffeine.
  • Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
  • Avoid stimulants and illegal drugs.
  • Call your doctor if it worsens.

Drug Warnings

If you are known to be allergic to Itratuf 200 Capsules or any other medicines, please tell your doctor. Itratuf 200 Capsules is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy, or are a nursing mother, it is advised to consult a doctor before using Itratuf 200 Capsules . Avoid taking fentanyl (a strong opioid pain killer narcotic medicine) with Itratuf 200 Capsules , as it may cause severe breathing problems and can even lead to death. Do not take Itratuf 200 Capsules if you had heart failure as it may cause severe life-threatening adverse effects. If you experience a yellow colour change of your eyes or skin, dark coloured urine, stomach pain, pale stools, loss of appetite, unusual tiredness, vomiting or nausea, stop taking Itratuf 200 Capsules and consult a doctor immediately as they might be symptoms of liver failure. If you have kidney, liver, heart, or lung problems, inform your doctor before taking Itratuf 200 Capsules .

Drug-Drug Interactions

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ItraconazoleNisoldipine
Critical
ItraconazoleTriazolam
Critical

Drug-Drug Interactions

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ItraconazoleNisoldipine
Critical
How does the drug interact with Itratuf 200 Capsules:
The blood levels and effects of nisoldipine may be greatly increased when used with Itratuf 200 Capsules.

How to manage the interaction:
Nisoldipine and Itratuf 200 Capsules may interact, but if prescribed by a doctor, they can be used together. Consult a physician if you have symptoms that include an irregular heartbeat, accumulation of fluid in legs or hands, or abnormally low blood pressure. Without consulting a doctor, never stop taking any medication.
ItraconazoleTriazolam
Critical
How does the drug interact with Itratuf 200 Capsules:
Co-administration of Triazolam and Itratuf 200 Capsules may significantly increase the levels of Triazolam.

How to manage the interaction:
Although combining Triazolam and Itratuf 200 Capsules may possibly lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
Alprazolam's blood levels may be significantly raised when combined with Itratuf 200 Capsules.

How to manage the interaction:
Although combining Alprazolam and Itratuf 200 Capsules may lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
Co-administartion of avanafil and Itratuf 200 Capsules may considerably raise the blood levels of Avanafil.

How to manage the interaction:
Although combining avanafil and Itratuf 200 Capsules may possibly lead to an interaction, they can be taken if prescribed by a doctor. Consult a physician if you develop any side effects, including priapism (prolonged and painful erection unrelated to sexual activity), low blood pressure, fainting, visual problems, including loss of vision, ringing in the ears, hearing loss, and low blood pressure. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
The blood levels and effects of solifenacin may be greatly increased when combined with Itratuf 200 Capsules.

How to manage the interaction:
Solifenacin and Itratuf 200 Capsules may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
The blood levels and effects of Ranolazine may be greatly increased when it is used with Itratuf 200 Capsules.

How to manage the interaction:
Although Ranolazine and Itratuf 200 Capsules may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop any negative symptoms, including fainting, lightheadedness, dizziness, or rapid heartbeat. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
Simvastatin's blood levels and effects may be greatly increased when combined with Itratuf 200 Capsules.

How to manage the interaction:
Simvastatin and Itratuf 200 Capsules may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Itratuf 200 Capsules:
Coadministration of Itratuf 200 Capsules with Disopyramide can reduce the metabolism and increase the levels of Disopyramide in the body. This may increase the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Itratuf 200 Capsules with Disopyramide together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dizziness, irritation, confusion, chest pain or tightness, swelling, fatigue, palpitations, shortness of breath, or constipation, you should contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Itratuf 200 Capsules:
Coadministration of Itratuf 200 Capsules with Silodosin can increase the blood levels and effects of Silodosin, which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Itratuf 200 Capsules with Silodosin together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Itratuf 200 Capsules:
Co-administration of Methylergometrine and Itratuf 200 Capsules may increase the blood levels of Methylergometrine.

How to manage the interaction:
Methylergometrine and Itratuf 200 Capsules may interact, but if prescribed by a doctor, they can be used together. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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ITRACONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ITRACONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming Grapefruit, Grapefruit juice with Itratuf 200 Capsules may impair the absorption of Itratuf 200 Capsules, resulting in decreased antifungal effects. Avoid consuming Grapefruit and grapefruit juice with Itratuf 200 Capsules.

Diet & Lifestyle Advise

  • Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
  • In wet places such as changing rooms and gym showers, don’t walk on barefoot to prevent fungal infections.
  • Do not scratch the affected area of skin as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bed sheets and towels regularly.

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

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Alcohol

Safe if prescribed

Avoid consumption of alcohol with Itratuf 200 Capsules as it may increase the risk of liver problems and other adverse effects.

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Pregnancy

Consult your doctor

Itratuf 200 Capsules is category C pregnancy drug and is unsafe for pregnant women as it may cause harm to the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Itratuf 200 Capsules .

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Breast Feeding

Consult your doctor

Itratuf 200 Capsules is excreted in human milk and may harm the baby. Therefore, Itratuf 200 Capsules is given to breastfeeding mothers only if doctor thinks benefits are greater than risks.

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Driving

Safe if prescribed

Itratuf 200 Capsules may cause dizziness, hearing loss, double or blurred vision in some people. Therefore, drive only if you alert after taking Itratuf 200 Capsules .

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Liver

Consult your doctor

Take Itratuf 200 Capsules with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Consult your doctor

Take Itratuf 200 Capsules with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Safe if prescribed

Itratuf 200 Capsules is not recommended for children below 12 years as the safety and effectiveness were not established.

FAQs

You are not recommended to take Itratuf 200 Capsules with simvastatin as co-administration of these two medicines may cause muscle weakness, unexplained muscle pain or tenderness, dark coloured urine, fever or flu symptoms. However, please consult a doctor before using Itratuf 200 Capsules with other medicines.

No, Itratuf 200 Capsules is not recommended for use during pregnancy as it may cause harm to the fetus. Also, it is advised to use effective contraceptive measures while taking Itratuf 200 Capsules and after 2 months of stopping treatment with Itratuf 200 Capsules . However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Itratuf 200 Capsules .

Itratuf 200 Capsules may cause temporary or permanent hearing loss in some people. It is not necessary for everyone taking Itratuf 200 Capsules to experience this adverse effect. However, if you notice any changes in hearing, stop taking Itratuf 200 Capsules and consult a doctor immediately.

You are advised to take antacids (drugs used to reduce acid in the stomach) such as omeprazole, pantoprazole and esomeprazole at least 1 hour before or 2 hours after taking Itratuf 200 Capsules as co-administration of these medicines at the same time may reduce the effectiveness of Itratuf 200 Capsules because antacids decrease the absorption and blood levels of Itratuf 200 Capsules . However, please consult a doctor before taking other medicines with Itratuf 200 Capsules .

Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.

You are not recommended to stop taking Itratuf 200 Capsules without consulting your doctor as it may cause recurring infection. Therefore, take Itratuf 200 Capsules for as long as your doctor has prescribed it, and if you experience any difficulty while taking Itratuf 200 Capsules , please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ITR0328

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