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  3. Joclab 10 mg Injection 10 ml

Joclab 10 mg Injection 10 ml, Pack of 1
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

CLADRIBINE-1MG/ML

Manufacturer/Marketer :

Jodas Expoim Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Joclab 10 mg Injection 10 ml

Joclab 10 mg Injection 10 ml belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

Joclab 10 mg Injection 10 ml contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

Joclab 10 mg Injection 10 ml may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of Joclab 10 mg Injection 10 ml do not require medical attention and gradually resolve over time. A trained healthcare professional will administer Joclab 10 mg Injection 10 ml. Hence, do not self-administer.

If you are allergic to Joclab 10 mg Injection 10 ml, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with Joclab 10 mg Injection 10 ml. Joclab 10 mg Injection 10 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of Joclab 10 mg Injection 10 ml

Hairy cell Leukemia.

Directions for Use

An oncology doctor will administer Joclab 10 mg Injection 10 ml. Self-administration is not recommended.

Medicinal Benefits

Joclab 10 mg Injection 10 ml contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Joclab 10 mg Injection 10 ml stops the multiplication of abnormal cells and causes the death of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Joclab 10 mg Injection 10 ml
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Receive vaccinations to guard against bacterial infections.
  • Maintain good hygiene by washing hands often and covering your mouth/nose when coughing or sneezing.
  • Make sure to store, cook, and handle food properly, to prevent food-borne infections.
  • Regularly clean surfaces that are touched often with disinfectants.
  • Protect yourself from insect bites by using repellents and wearing appropriate clothing, especially in high-risk areas.
  • Use latex or polyurethane condoms during sex to minimize the risk of infections.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

Drug Warnings

If you are allergic to Joclab 10 mg Injection 10 ml, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with Joclab 10 mg Injection 10 ml. Joclab 10 mg Injection 10 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.

Drug-Drug Interactions

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CladribineTemozolomide
Severe
CladribineEtoposide
Severe

Drug-Drug Interactions

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CladribineTemozolomide
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Using Joclab 10 mg Injection 10 ml together with temozolomide may increase the risk of serious infections.

How to manage the interaction:
Although taking temozolomide and Joclab 10 mg Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
CladribineEtoposide
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml with Etoposide can increase the risk of serious infections.

How to manage the interaction:
Taking Etoposide with Joclab 10 mg Injection 10 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, make sure to contact the doctor right away. Do not stop using any medications without a doctor's advice.
CladribineHydroxycarbamide
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
The combined use of Joclab 10 mg Injection 10 ml and Hydroxycarbamide can increase the risk of infections.

How to manage the interaction:
Co-administration of Joclab 10 mg Injection 10 ml and hydroxycarbamide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CladribineDactinomycin
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
The combined use of Joclab 10 mg Injection 10 ml with dactinomycin can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Dactinomycin with Joclab 10 mg Injection 10 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.
CladribinePentostatin
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml with Pentostatin can increase the risk and severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Joclab 10 mg Injection 10 ml and Pentostatin, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without first talking to your doctor.
CladribineProcainamide
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml with Procainamide can increase the risk of infection.

How to manage the interaction:
Although taking Joclab 10 mg Injection 10 ml and Procainamide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
CladribineFluorouracil
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Combining Joclab 10 mg Injection 10 ml with Fluorouracil can increase the risk of side effects.

How to manage the interaction:
Taking Joclab 10 mg Injection 10 ml with Fluorouracil together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineRomidepsin
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml together with romidepsin may increase the risk of serious infections.

How to manage the interaction:
Taking Joclab 10 mg Injection 10 ml with Romidepsin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
CladribineSirolimus
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Co-administration of Joclab 10 mg Injection 10 ml with Sirolimus can increase the risk and severity of developing infections.

How to manage the interaction:
Although there is a possible interaction between Sirolimus and Joclab 10 mg Injection 10 ml, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineBendamustine
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Combining Joclab 10 mg Injection 10 ml with Bendamustine can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Bendamustine and Joclab 10 mg Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:18 PM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Joclab 10 mg Injection 10 ml contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

It is said that concomitant use of Joclab 10 mg Injection 10 ml along with live vaccines may cause serious adverse effects. Hence, inform your doctor if you have taken any vaccines recently before receiving Joclab 10 mg Injection 10 ml.

Special Advise

Regular blood tests are recommended while receiving Joclab 10 mg Injection 10 ml to monitor any signs of anemia, neutropenia and thrombocytopenia.

Disease/Condition Glossary

Hairy cell Leukemia: It is a rare type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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