Keysom L Capsule 10's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

MRP ₹250

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₹37.5 Cashback (15%)

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Whats That

About Keysom L Capsule

Keysom L Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.

Keysom L Capsule contains Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Keysom L Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

You are advised to take Keysom L Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Inform your doctor before taking Keysom L Capsule if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Keysom L Capsule may increase the risk of bone fractures. Consult your doctor if you are pregnant or breastfeeding. Keysom L Capsule may cause drowsiness and dizziness, so drive only if you are alert. Keysom L Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Keysom L Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Uses of Keysom L Capsule

Gastro-oesophageal reflux disease.

Directions for Use

Take Keysom L Capsule 1hour prior food. Swallow Keysom L Capsule as a whole with a glass of water, do not chew, or crush it.

Medicinal Benefits

Keysom L Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). Keysom L Capsule is a combination of two drugs, namely: Esomeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Keysom L Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.

Storage

Keep Keysom L Capsule out of reach and sight of children.

Side effects of Keysom L Capsule

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Gas Or Fart

Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:

Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Dry Mouth

Here are the steps to Dry Mouth (xerostomia) caused by medication:

Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Drug Warnings

Do not take Keysom L Capsule if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Keysom L Capsule if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Keysom L Capsule may increase the risk of bone fractures. Do not take Keysom L Capsule if you are pregnant or breastfeeding. Keysom L Capsule may cause dizziness and drowsiness, so drive only if you are alert. Keysom L Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Keysom L Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Drug-Drug Interactions

EsomeprazoleRilpivirine

Critical

EsomeprazoleGefitinib

Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine

Critical

How does the drug interact with Keysom L Capsule:
Keysom L Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Keysom L Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.

EsomeprazoleGefitinib

Severe

How does the drug interact with Keysom L Capsule:
Taking gefitinib with Keysom L Capsule may reduce the effectiveness of gefitinib.

How to manage the interaction:
Although taking Keysom L Capsule and Gefitinib together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Gefitionib 12 hours before or after taking Keysom L Capsule. Do not stop taking any medications without consulting a doctor.

EsomeprazoleMethotrexate

Severe

How does the drug interact with Keysom L Capsule:
Co-administration of methotrexate and Keysom L Capsule can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Keysom L Capsule with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.

EsomeprazoleDasatinib

Severe

How does the drug interact with Keysom L Capsule:
Using Dasatinib together with Keysom L Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Keysom L Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

EsomeprazoleErlotinib

Severe

How does the drug interact with Keysom L Capsule:
Coadministration of erlotinib and Keysom L Capsule can reduce effects of erlotinib.

How to manage the interaction:
Taking Erlotinib and Keysom L Capsule together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.

EsomeprazoleTacrolimus

Severe

How does the drug interact with Keysom L Capsule:
Taking tacrolimus with Keysom L Capsule may significantly increase the blood levels of tacrolimus, which can lead to an increased risk of side effects.

How to manage the interaction:
Although taking Keysom L Capsule with Tacrolimus can result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience irregular heartbeat, blurring of vision, fever, chills, or muscle spasms. Do not discontinue any medications without consulting a doctor.

EsomeprazoleAtazanavir

Severe

How does the drug interact with Keysom L Capsule:
Keysom L Capsule reduces the absorption of atazanavir, resulting in reduced efficacy of atazanavir.

How to manage the interaction:
Although there is a possible interaction between Keysom L Capsule and atazanavir, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

EsomeprazoleNelfinavir

Severe

How does the drug interact with Keysom L Capsule:
Taking nelfinavir with Keysom L Capsule may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Keysom L Capsule and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.

EsomeprazoleAcalabrutinib

Severe

How does the drug interact with Keysom L Capsule:
Keysom L Capsule may interfere with the absorption of Acalabrutinib and reduce their efficacy.

How to manage the interaction:
Taking Keysom L Capsule with Acalabrutinib together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.

EsomeprazoleDacomitinib

Severe

How does the drug interact with Keysom L Capsule:
Keysom L Capsule can make Dacomitinib less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Co-administration of Keysom L Capsule with Dacomitinib can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat smaller meals more often.
Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Maintain a healthy weight by regular exercising.
Avoid lying down after eating as it causes acid reflux.
Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
Practise relaxation techniques and avoid stress by doing yoga or meditation.
Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Side Effects of Keysom L Capsule

Headache
Abdominal pain
Flushing
Dry mouth
Constipation
Diarrhoea
Flatulence
Nausea
Vomiting

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:31 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Keysom L Capsule work?

Keysom L Capsule is a combination of two drugs, namely: Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Keysom L Capsule helps in preventing acid reflux, thereby providing relief from acidity.

Does Keysom L Capsule cause diarrhoea?

Diarrhoea might be a side-effect of Keysom L Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Can I take Keysom L Capsule with nelfinavir?

Do not take Keysom L Capsule with nelfinavir (a drug used to treat HIV infections). Consult your doctor before taking Keysom L Capsule with other medicines to rule out unpleasant side-effects.

Does Keysom L Capsule cause bone fractures?

Keysom L Capsule contains esomeprazole which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking Keysom L Capsule for longer durations. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, your doctor may prescribe calcium and vitamin D supplements.

Does Keysom L Capsule affect diagnostic test results?

Keysom L Capsule may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Keysom L Capsule .

Does Keysom L Capsule cause dry mouth?

Dry mouth could be a side-effect of Keysom L Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Drug-Drug Interactions Checker List

ASPIRIN
NAPROXEN
ATAZANAVIR
CLOPIDOGREL
WARFARIN
CILOSTAZOL
KETOCONAZOLE
ITRACONAZOLE
VORICONAZOLE
ERLOTINIB
METHOTREXATE
CITALOPRAM
IMIPRAMINE
CLOMIPRAMINE
DULOXETINE
DIAZEPAM
PHENYTOIN
CISAPRIDE
DIGOXIN
TACROLIMUS
RIFAMPICIN

Special Advise

Keysom L Capsule may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Keysom L Capsule .
Inform your doctor before taking Keysom L Capsule if you are due to have Chromogranin A test.

Disease/Condition Glossary

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.