K-Mac Oral Solution 450 ml

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Hari Kumar , MBBS

MRP ₹252

(Inclusive of all Taxes)

₹37.8 Cashback (15%)

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Non returnable*

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Prescription drug

Whats That

About K-Mac Oral Solution

K-Mac Oral Solution is indicated for the treatment of renal tubular acidosis and kidney stones due to low citric acid levels or high uric acid. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. Renal tubular acidosis is a condition in which the kidneys fail to excrete acids into the urine, this causes the blood to remain too acidic.

K-Mac Oral Solution is a combination of two drugs, namely: Magnesium citrate and Potassium citrate. K-Mac Oral Solution raises the urinary pH, potassium, magnesium and citric acid levels; this prevents the crystallisation, growth and accumulation of stone-forming salts.

You are advised to take K-Mac Oral Solution for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as abdominal discomfort, diarrhoea, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking K-Mac Oral Solution if you are pregnant or breastfeeding. K-Mac Oral Solution is not recommended for children as safety and effectiveness have not been established. It is not known if alcohol interacts with K-Mac Oral Solution , so please consult a doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of K-Mac Oral Solution

Kidney stones, renal tubular acidosis.

Directions for Use

Check the label for directions before use. The prescribed dose of K-Mac Oral Solution should be diluted with a glass of water and taken after meals/bedtime or as advised by the doctor.

Medicinal Benefits

K-Mac Oral Solution is a combination of two drugs, namely: Magnesium citrate and Potassium citrate. K-Mac Oral Solution is indicated for the treatment of renal tubular acidosis with calcium stones, uric acid lithiasis with or without calcium stone, hypocitraturic calcium oxalate nephrolithiasis (kidney stones). K-Mac Oral Solution raises the urinary pH, potassium, magnesium and citric acid levels; this prevents the crystallisation, growth and accumulation of stone-forming salts.

Storage

Keep K-Mac Oral Solution out of reach and sight of children.

Side effects of K-Mac Oral Solution 450 ml

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

High Potassium Levels In The Blood

Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
Limit dairy products to 200g of yoghurt or 300ml of milk per day.

Drug Warnings

Do not take K-Mac Oral Solution if you are allergic to any of its components; if you have hyperkalaemia (high levels of potassium), delayed gastric emptying, intestinal obstruction, peptic ulcers, urinary tract infection, or renal insufficiency. Inform your doctor if you have gastrointestinal lesions. If you experience severe vomiting, gastrointestinal bleeding or abdominal pain, stop taking K-Mac Oral Solution and consult a doctor immediately. K-Mac Oral Solution is not recommended for children as safety and effectiveness have not been established. Consult your doctor before taking K-Mac Oral Solution if you are pregnant or breastfeeding.

Drug-Drug Interactions

Magnesium citrateEltrombopag

Critical

Potassium citrateHydroxyzine

Critical

Drug-Drug Interactions

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Magnesium citrateEltrombopag

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking K-Mac Oral Solution 450 ml with Eltrombopag can make it less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Taking K-Mac Oral Solution 450 ml with Eltrombopag is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. You should take eltrombopag on an empty stomach at least 2 hours before or 4 hours after K-Mac Oral Solution 450 ml. Do not discontinue any medication without consulting a doctor.

Potassium citrateHydroxyzine

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Hydroxyzine and K-Mac Oral Solution 450 ml (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Hydroxyzine with K-Mac Oral Solution 450 ml is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Potassium citrateOlanzapine

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Olanzapine with K-Mac Oral Solution 450 ml can increase the irritant effects of potassium on your stomach and upper intestine.

How to manage the interaction:
Co-administration of Olanzapine and K-Mac Oral Solution 450 ml is not recommended as it leads to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Potassium citrateTrospium

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking K-Mac Oral Solution 450 ml and trospium together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trospium with K-Mac Oral Solution 450 ml is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Potassium citrateProcyclidine

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Procyclidine and K-Mac Oral Solution 450 ml together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking procyclidine with K-Mac Oral Solution 450 ml is not recommended, but it can be taken together if advised by your doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Potassium citrateDisopyramide

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Disopyramide and K-Mac Oral Solution 450 ml together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Although taking Disopyramide and K-Mac Oral Solution 450 ml together is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Potassium citrateNortriptyline

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Coadministration of Nortriptyline with K-Mac Oral Solution 450 ml can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Nortriptyline with K-Mac Oral Solution 450 ml together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Potassium citrateDicyclomine

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Dicyclomine and K-Mac Oral Solution 450 ml together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Dicyclomine with K-Mac Oral Solution 450 ml is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Potassium citrateOxybutynin

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Coadministration of Oxybutynin and K-Mac Oral Solution 450 ml can increase the risk of developing stomach ulcers or bleeding.

How to manage the interaction:
Taking Oxybutynin with K-Mac Oral Solution 450 ml is generally avoided as it may lead to an interaction, it can be taken if prescribed by the doctor. Consult the doctor immediately if you experience severe stomach pain, bloating, lightheadedness, dizziness, vomiting (especially with blood), decreased hunger, or dark stools. Do not discontinue any medications without a doctor's advice.

Potassium citrateEplerenone

Critical

How does the drug interact with K-Mac Oral Solution 450 ml:
Taking Eplerenone with K-Mac Oral Solution 450 ml may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between K-Mac Oral Solution 450 ml and Eplerenone, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Drink plenty of fluids as they help in flushing out excess minerals.
Limit salt intake. High amounts of salt can increase the risk of kidney stones.
Maintain a healthy weight by exercising regularly.
Avoid foods rich in oxalates such as spinach, nuts, okra, dates, avocado, hot chocolate, cocoa, baked potato, french fries, and cereals as they might increase the risk of oxalate stones.
Try maintaining optimum levels of calcium in the body as too little or high calcium can lead to kidney stones.

Side Effects of K-Mac Oral Solution

Abdominal discomfort
Diarrhoea
Vomiting
Nausea

Habit Forming

No

Therapeutic Class

RENAL AND GENITOURINARY AGENT

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:39 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does K-Mac Oral Solution work?

K-Mac Oral Solution contains Magnesium citrate and Potassium citrate. K-Mac Oral Solution raises the urinary pH, potassium, magnesium and citric acid levels; this prevents the crystallisation of stone-forming salts.

Can I stop taking K-Mac Oral Solution if I feel well?

To treat your condition effectually, continue taking K-Mac Oral Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking K-Mac Oral Solution .

I have peptic ulcers. Can I take K-Mac Oral Solution ?

Avoid taking K-Mac Oral Solution if you have peptic ulcers as K-Mac Oral Solution has ulcerogenic potential, which could lead to further ulceration.

Does K-Mac Oral Solution cause diarrhoea?

Diarrhoea might be a side-effect of K-Mac Oral Solution . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Is it safe to take K-Mac Oral Solution if I have a urinary tract infection?

Consult a doctor before taking K-Mac Oral Solution if you have an active urinary tract infection, as K-Mac Oral Solution increases the urinary pH, which might promote further bacterial growth.

Drug-Drug Interactions Checker List

TRIAMTERENE
SPIRONOLACTONE
AMILORIDE

Disease/Condition Glossary

Kidney stones: Nephrolithiasis, also known as kidney stones, is a disease affecting the urinary tract. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. They are the common cause of blood in urine and can be painful when passing through the urinary tract. Symptoms include severe pain, usually in one side of the abdomen and nausea.

Renal tubular acidosis: It is a condition that involves the accumulation of acid in the body due to the failure of the kidneys to acidify the urine appropriately. The kidneys fail to excrete acids into the urine, which causes the blood to remain too acidic. If not treated, it could lead to kidney stones, bone disease, kidney disease or failure.