Trospium
About
Trospium belongs to the class of drugs called antimuscarinics used to treat overactive bladder (OAB) symptoms. Overactive bladder is a problem with bladder function that causes a sudden urge to urinate. Overactive bladder symptoms include frequent urination, involuntary loss of urine, an urgent and uncontrollable need to urinate, or bedwetting.
Trospium contains Trospium which works by blocking muscarinic receptors on the surface of muscle cells and inhibits the action of acetylcholine (a chemical messenger) that causes contraction of the bladder muscle. Thereby, Trospium relaxes the involuntary muscle (detrusor) in the bladder wall and reduces unstable and involuntary contractions of the bladder, and increases the bladder's capacity to hold urine. Thus, it decreases the need to urinate.
Take Trospium as prescribed by your doctor. You are advised to take Trospium for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dry mouth, nausea, stomach pain, indigestion, or constipation. Most of these side effects of Trospium do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Trospium or any other medicines, please tell your doctor. Trospium is not recommended for children below 12 years as the safety and effectiveness were not established. Please consult a doctor if you are pregnant or breastfeeding before taking Trospium. Do not consume alcohol with Trospium as it may increase the risk of adverse effects. You are recommended to drink plenty of water while taking Trospium to prevent dryness of the mouth. Drive only if your vision is clear after taking Trospium as it may cause blurred vision in some people for a short duration.
Uses of Trospium
Medicinal Benefits
Trospium contains Trospium used to treat overactive bladder symptoms. Trospium blocks muscarinic receptors on the muscle cells and inhibits the action of acetylcholine (a chemical messenger) that causes contraction of the bladder muscle. Thereby, Trospium relaxes the involuntary muscle (detrusor) in the bladder wall and reduces unstable and involuntary contractions of the bladder and increases bladder capacity to hold urine. Thus, it decreases the need to urinate.
Directions for Use
Storage
Side Effects of Trospium
- Dry mouth
- Nausea
- Stomach pain
- Indigestion
- Constipation
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Trospium or any other medicines, please tell your doctor. If you have nerve damage, overactive thyroid, hernia of the diaphragm with inflammation of the esophagus, liver, kidney, or heart problems, inform your doctor before taking Trospium. Trospium is not recommended for children below 12 years as the safety and effectiveness were not established. Please consult a doctor if you are pregnant or breastfeeding before taking Trospium. Do not consume alcohol with Trospium as it may increase the risk of adverse effects. You are recommended to drink plenty of water while taking Trospium to prevent dryness of the mouth. Avoid taking Trospium if you have urinary retention, serious liver disorder, narrow-angle glaucoma, irregular heartbeats, myasthenia gravis (muscle weakness), and toxic megacolon (severe gastrointestinal condition). Drive only if your vision is clear after taking Trospium as it may cause blurred vision in some people for a short duration.
Drug Interactions
Drug-Drug Interactions: Trospium may have interaction with antidepressants (imipramine, amitriptyline), medicines to treat asthma (salbutamol), antiemetic (metoclopramide), high cholesterol-lowering drugs (colestipol, cholestyramine), antimuscarinic agent (mirabegron), pain reliever and fever reducer (acetaminophen), high blood pressure-lowering medicines (metoprolol), and anti-allergic drugs (diphenhydramine).
Drug-Food Interactions: Trospium may interact with alcohol. Therefore, avoid consumption with Trospium as it may increase the risk of adverse effects of Trospium.
Drug-Disease Interactions: Avoid taking Trospium if you have urinary retention, narrow-angle glaucoma, irregular heartbeats, myasthenia gravis (muscle weakness), and toxic megacolon (severe gastrointestinal condition). If you have nerve damage, overactive thyroid, hernia of the diaphragm with inflammation of the esophagus, liver, kidney, or heart problems, inform your doctor before taking Trospium.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid consumption of alcohol with Trospium as it may increase the risk of adverse effects of Trospium.
Pregnancy
cautionTrospium is a category C pregnancy drug and is given to pregnant women only if the doctor thinks benefits outweigh risks. However, please consult a doctor if you are pregnant.
Breast Feeding
cautionIt is unknown whether Trospium is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding. Trospium is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.
Driving
cautionTrospium may cause blurred vision in some people. Therefore, wait until your vision is clear before driving or operating heavy machinery.
Liver
cautionTake Trospium with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Trospium if you have severe liver disease.
Kidney
cautionTake Trospium with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeTrospium is not recommended for children below 12 years as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Pelvic floor exercises would help treat bladder spasms.
- Avoid foods like sugars, carbonated beverages, tea, citrus fruits, tomatoes, spicy foods, chocolate and tea.
- Limit fluid intake as excess fluid intake could cause an urge to urinate frequently.
- Avoid drinking excess alcohol or caffeinated drinks as they can worsen the symptoms.
- Maintain a healthy weight, and exercise regularly.
- Avoid smoking and alcohol intake.
- Take 6-8 glasses of liquids every day.
- Avoid processed foods. Instead, choose whole, unprocessed foods.
- Include fruits, vegetables, and fiber-rich food in your diet.
Special Advise
Please consult a doctor if the condition persists or worsens after using Trospium for 1 month.
Patients Concern
Disease/Condition Glossary
Overactive bladder: It is a problem with bladder function that causes a sudden urge to urinate. An overactive bladder causes bladder muscles' involuntary contractions, giving the sensation of an urge to urinate frequently even if the bladder is not full. It mostly occurs in women than in men. An overactive bladder in men may be due to an enlarged prostate gland as it blocks urine flow. Overactive bladder may be caused due to urinary tract infections, drinking too many fluids, bladder stones, taking medicines that increase urine production, alcohol consumption, caffeine or other bladder irritants, or failure to empty the bladder. Overactive bladder symptoms include frequent urination (more than 8 times a day), involuntary loss of urine, an urgent and uncontrollable need to urinate, or bedwetting.
FAQs
The Trospium contains Trospium that works by relaxing the involuntary muscle (detrusor) in the bladder wall responsible for overactive bladder by contracting in uncontrollable spasms. Thereby, Trospium reduces the bladder's involuntary and unstable contractions and increases bladder capacity to hold urine. Thus, it decreases the need to urinate.
Trospium may cause dryness of the mouth as a side effect. It is not necessary for everyone taking Trospium to experience this side effect. Therefore, drink plenty of water, chew sugar-free gum or candy, limit caffeine intake, avoid smoking and alcohol-containing mouthwashes to prevent dry mouth.
You are not recommended to take Trospium with diphenhydramine (anti-allergic drug) as co-administration of these two medicines may increase adverse effects such as blurred vision, dry mouth, drowsiness, decreased sweating, confusion, irregular heartbeat, memory problems or constipation. However, please consult a doctor before taking Trospium with other medicines.
Trospium may increase the risk of heatstroke as it may decrease sweating and leads to overheating. Therefore, drink plenty of water while taking Trospium to prevent dehydration and avoid becoming dehydrated or overheated during exercise and in hot weather.
Trospium is not recommended for patients suffering from narrow-angle glaucoma as it may worsen the condition. Therefore, inform your doctor if you have glaucoma or any other eye problems before taking Trospium.
Trospium may cause temporary blurred vision in some patients. However, avoid driving or operating machinery until your vision is clear.
