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Written By Urvashi Bharti , MBBS
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Synonym :

CALCITONIN SALMON

Composition :

CALCITONIN-200IU

Manufacturer/Marketer :

Biodeal Pharmaceuticals Pvt Ltd

Return Policy :

Not Returnable

Expires on or after :

About Knogle 200 Nasal Spray 60Md 6Ml

Knogle 200 Nasal Spray 60Md 6Ml belongs to groups of medications called hypocalcemic agents, used to treat high blood calcium levels (hypercalcemia) and Postmenopausal Osteoporosis. Besides this, it can also help treat complications of Paget's disease. Hypercalcemia is a condition in which the calcium level in your blood is above normal. Postmenopausal osteoporosis is a medical condition that causes thinning and weakening of the bones during/after a menopausal period. Paget’s disease is a chronic disease of bone that disrupts the replacement of old bone tissue with new bone tissue, resulting in the new bone that is abnormally shaped, weak and brittle.

Knogle 200 Nasal Spray 60Md 6Ml contains Calcitonin. It reduces the activity of osteoclasts, which are the cells responsible for bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. As a result, calcitonin's suppression of osteoclasts limits the quantity of calcium released into the blood. Furthermore, it can reduce calcium resorption in the kidneys, resulting in decreased blood calcium levels.

Knogle 200 Nasal Spray 60Md 6Ml will be administered by a qualified healthcare professional. Kindly do not self-administer. In some cases, Knogle 200 Nasal Spray 60Md 6Ml can cause side effects, including injection site reactions, nausea with or without vomiting and flushing of the face or hands. Most of these side effects of Knogle 200 Nasal Spray 60Md 6Ml do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Before taking the Knogle 200 Nasal Spray 60Md 6Ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Knogle 200 Nasal Spray 60Md 6Ml should not be given to children as safety and efficacy have not been established.

Uses of Knogle 200 Nasal Spray 60Md 6Ml

Postmenopausal osteoporosis, Paget’s disease, Hypercalcemia.

Directions for Use

Knogle 200 Nasal Spray 60Md 6Ml will be administrated by a healthcare professional. Do not self-administer.

Medicinal Benefits

Knogle 200 Nasal Spray 60Md 6Ml contains calcitonin, which belongs to groups of medications called hypocalcemic agents and is used to treat high blood calcium levels (hypercalcemia) and Postmenopausal Osteoporosis. On the other hand, it can also help people with Paget's disease of bone. Knogle 200 Nasal Spray 60Md 6Ml reduces the activity of osteoclasts, which are the cells responsible for bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. As a result, calcitonin's suppression of osteoclasts limits the quantity of calcium released into the blood. Furthermore, it can reduce calcium resorption in the kidneys, decreasing blood calcium levels.

Storage

Store in a cool and dry place away from sunlight
Side effects of Knogle 60 MDI Nasal Spray 6 ml
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drug Warnings

Before taking the Knogle 200 Nasal Spray 60Md 6Ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Knogle 200 Nasal Spray 60Md 6Ml should not be given to children as safety and efficacy have not been established. In rare situations, Knogle 200 Nasal Spray 60Md 6Ml may cause major hypersensitivity reactions in individuals receiving Miacalcin injection, including bronchospasm, inflammation of the tongue or throat and anaphylactic shock. If you encounter any of these symptoms, contact your doctor right once.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Knogle 60 MDI Nasal Spray 6 ml:
Etelcalcetide may decrease the calcium levels in the blood. Concomitant use with calcitonin may increase the risk of hypocalcemia, or low blood calcium.

How to manage the interaction:
Although there is an interaction, calcitonin can be taken with etelcalcetide if prescribed by the doctor. Consult the prescriber if you notice symptoms of hypocalcemia like numbness or tingling around your mouth, muscle spasms, or mental changes (irritability, depression, psychosis). Do not discontinue using any medication without contacting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A person should consume calcium and vitamin D in their diet as it helps make stronger bones and avoid everyday osteoporosis dangers.
  • A post-menopausal woman should limit salt intake as it can pose a high risk of losing more bone minerals than other women of the same age.
  • Do regular exercise like weight-bearing exercises which are important for maintaining bone health.
  • Calcium is important for making bones strong. Vitamin D is equally important, which helps to ensure the absorption and retention of calcium in bones, so take food high in calcium and vitamins.

Habit Forming

No

Therapeutic Class

HYPOCALCEMIC AGENTS

Author Details

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Drug-Diseases Interactions

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CALCITONIN-200IUDisorders of mineral metabolism
Moderate
CALCITONIN-200IUDisorders of mineral metabolism
Moderate

Drug-Diseases Interactions

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CALCITONIN-200IUDisorders of mineral metabolism
Moderate
How does the disease interact with Knogle 60 MDI Nasal Spray 6 ml:
Calcium levels in the serum are reduced . Patients who already have hypocalcemia should use caution when administering calcium to prevent unwanted side effects. It is preferable to address hypocalcemia before beginning medication. A sufficient intake of calcium and vitamin D should be made sure during the course of treatment if calcitonin is used to promote bone mineral density, as in the case of osteoporosis

How to manage the interaction:
Calcitonin may cause hypocalcemic effects. Therefore, it should be administered cautiously to patients with preexisting hypocalcemia, since they may be particularly sensitive to these effects.
CALCITONIN-200IUDisorders of mineral metabolism
Moderate
How does the disease interact with Knogle 60 MDI Nasal Spray 6 ml:
Prior to beginning medication, hypocalcemia and other abnormalities of mineral metabolism, such as vitamin D deficiency, should be corrected when calcitonin is used to treat osteoporosis. The body must have an adequate quantity of calcium and vitamin D for the necessary increase in bone mineral density to occur. When treating patients with these conditions with calcitonin salmon nasal spray, serum calcium and hypocalcemia symptoms should be kept under close observation. Throughout the course of treatment, it is important to ensure an adequate intake of calcium and vitamin D

How to manage the interaction:
In patients with mineral metabolism disorders, serum calcium and symptoms of hypocalcemia should be monitored during therapy. Appropriate intake of calcium and vitamin D should be ensured throughout the course of treatment.

FAQs

Knogle 200 Nasal Spray 60Md 6Ml contains Calcitonin. It reduces the activity of osteoclasts, which are the cells responsible for bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. As a result, calcitonin's suppression of osteoclasts limits the quantity of calcium released into the blood. Furthermore, it can reduce calcium resorption in the kidneys, resulting in decreased blood calcium levels.

If you have osteoporosis, avoid smoking, or try to quit. Smoking can reduce bone mineral density and increases the risk of fractures.

Knogle 200 Nasal Spray 60Md 6Ml contains Calcitonin, a hormone that regulates the calcium level in the blood. This hormone helps in bone formation and also helps the body to reverse bone loss. Due to this, the number of cells that damages bones becomes comparatively less. Hence, the bone damage is halted. Using Knogle 200 Nasal Spray 60Md 6Ml can increase bone formation by activation of the bone-forming cells.

Persons whose age is more than 45 years have low estrogen levels, females reaching menopause, too much consumption of alcohol, tobacco or caffeine, use of glucocorticoids and lack of calcium and vitamin D in foods are some of the factors that can increase the risk of osteoporosis.

Yes, Knogle 200 Nasal Spray 60Md 6Ml is used together with calcium and vitamin D to treat bone loss in women with postmenopausal osteoporosis who have been postmenopausal for at least five years. Knogle 200 Nasal Spray 60Md 6Ml inhibits the function of osteoclasts (bone breakdown), reducing bone resorption; thus, combining calcium and calcitonin could result in a positive bone balance.

Drug-Drug Interactions Checker List

  • LITHIUM
  • ETELCALCETIDE
  • FOSCARNET

Special Advise

  • Certain diagnostic tests, like blood tests, measure the calcitonin level in your blood, and bone density scans are used to check bone mineral density (BMD).
  • Clinical monitoring of serum electrolyte concentrations is recommended.

Disease/Condition Glossary

Postmenopausal Osteoporosis: Postmenopausal Osteoporosis is a medical condition that causes thinning and weakening of the bones during/after a menopausal period. The chance of developing Osteoporosis (weak bone) is related to estrogen deficiency. During the menopausal period (45 years of age), the drop in estrogen leads to more bone resorption (osteoclasts; bone breakdown) than formation (osteoblast; new bone formation), resulting in Osteoporosis. In starting days, Osteoporosis does not show any symptoms. However, if proper treatment is not provided, it can lead to broken bones. Initially, the bones don't hurt, and breaks in the spine's bones may go unseen until they cause height loss. In Osteoporosis, bones can break at any time, even during daily activities like lifting or even from minor activities. 

Paget's disease: Paget's disease is a chronic disease of bone that disrupts the replacement of old bone tissue with new bone tissue, resulting in the new bone that is abnormally shaped, weak and brittle. It most commonly occurs in the pelvis, skull, spine, and legs. Symptoms include bone pain, joint pain (especially in the back, hips, and knees), headache, enlargement and bowing of the thighs (femurs) and lower legs (tibias), and enlargement of the skull in the area of the forehead.

Hypercalcemia: Hypercalcemia is when the calcium level in the blood is higher than normal. Too much calcium in the blood can weaken the bones, create kidney stones, and interfere with working the heart and brain. It is usually a result of overactive parathyroid glands. Symptoms include increased thirst and urination, stomach pain, nausea, bone pain, muscle weakness, confusion and fatigue.

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