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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

About Lefmaa 10Mg Tablet 10'S

Lefmaa 10Mg Tablet 10'S belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefmaa 10Mg Tablet 10'S contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefmaa 10Mg Tablet 10'S at the same time every day as prescribed by your doctor. In some cases, Lefmaa 10Mg Tablet 10'S may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefmaa 10Mg Tablet 10'S if you are pregnant or planning for pregnancy as Lefmaa 10Mg Tablet 10'S may cause serious congenital disabilities. Lefmaa 10Mg Tablet 10'S should not be taken by breastfeeding mothers as it passes into breast milk. Lefmaa 10Mg Tablet 10'S may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefmaa 10Mg Tablet 10'S as it could lead to increased dizziness and liver damage. Lefmaa 10Mg Tablet 10'S may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

LEFLUNOMIDE-10MG

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Lefmaa 10Mg Tablet 10'S

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits

Lefmaa 10Mg Tablet 10'S belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefmaa 10Mg Tablet 10'S is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Side Effects of Lefmaa 10Mg Tablet 10'S

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Directions for Use

Take Lefmaa 10Mg Tablet 10'S with or without food. Swallow Lefmaa 10Mg Tablet 10'S as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Lefmaa 10Mg Tablet 10'S if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefmaa 10Mg Tablet 10'S is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefmaa 10Mg Tablet 10'S if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefmaa 10Mg Tablet 10'S may cause dizziness, so drive with caution. Lefmaa 10Mg Tablet 10'S may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Therapeutic Class

ANTIRHEUMATICS

Drug-Drug Interactions

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LeflunomideFludrocortisone
Severe
LeflunomideNaltrexone
Severe

Drug-Drug Interactions

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LeflunomideFludrocortisone
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Taking Fludrocortisone with Lefmaa 10 mg Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Co-administration of Lefmaa 10 mg Tablet 10's with Fludrocortisone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination - contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideNaltrexone
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Taking Lefmaa 10 mg Tablet 10's and Naltrexone can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Lefmaa 10 mg Tablet 10's and Naltrexone, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideBupropion
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Lefmaa 10 mg Tablet 10's can cause liver issues, and combining it with bupropion, can enhance the risk.

How to manage the interaction:
Co-administration of bupropion along with Lefmaa 10 mg Tablet 10's can lead to interaction, it can be taken if recommended by a doctor. If you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideIdarubicin
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Taking Idarubicin and Lefmaa 10 mg Tablet 10's can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Lefmaa 10 mg Tablet 10's, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideKetoconazole
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Coadministration of Ketoconazole and Lefmaa 10 mg Tablet 10's may cause liver injury.

How to manage the interaction:
Although taking Ketoconazole and Lefmaa 10 mg Tablet 10's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideOlaparib
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Taking Lefmaa 10 mg Tablet 10's with olaparib may increase the risk of infections.

How to manage the interaction:
Although there is an interaction between Lefmaa 10 mg Tablet 10's and olaparib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMeloxicam
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
When Meloxicam and Lefmaa 10 mg Tablet 10's are taken together, can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Lefmaa 10 mg Tablet 10's and Meloxicam, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
LeflunomideDanazol
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Combining Lefmaa 10 mg Tablet 10's with Danazol may increase the risk of liver problems.

How to manage the interaction:
Although taking Danazol and Lefmaa 10 mg Tablet 10's together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideFlurbiprofen
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Using Flurbiprofen with Lefmaa 10 mg Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Lefmaa 10 mg Tablet 10's, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
LeflunomideIbrutinib
Severe
How does the drug interact with Lefmaa 10 mg Tablet 10's:
Co-administration of Ibrutinib and Lefmaa 10 mg Tablet 10's can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrutinib can be taken with Lefmaa 10 mg Tablet 10's, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting Lefmaa 10Mg Tablet 10'S, and for every 6-8 weeks are advised.

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Lefmaa 10Mg Tablet 10'S Substitute

Substitutes safety advice
  • Lefno-10 Tablet 10's

    13.50per tablet
  • Lefra 10 Tablet 10's

    13.50per tablet
  • Leftab 10 Tablet 10's

    9.36per tablet
  • Rumalef 10 Tablet 30's

    8.94per tablet
  • Dmlef 10mg Tablet 10's

    by AYUR

    12.51per tablet
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