Lefno-10 Tablet 10's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Sunny S , MBBS

MRP ₹165

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₹24.8 Cashback (15%)

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Whats That

About Lefno-10 Tablet

Lefno-10 Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales).

Lefno-10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Take Lefno-10 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefno-10 Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefno-10 Tablet if you are pregnant or planning for pregnancy as Lefno-10 Tablet may cause serious congenital disabilities. Lefno-10 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefno-10 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefno-10 Tablet as it could lead to increased dizziness and liver damage. Lefno-10 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefno-10 Tablet

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefno-10 Tablet with or without food. Swallow Lefno-10 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefno-10 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefno-10 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Keep Lefno-10 Tablet out of reach and sight of children.

Side effects of Lefno-10 Tablet

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Indigestion

Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:

Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Respiratory Infection

Hair Loss

Eat protein-rich foods like fish, poultry, eggs, and legumes.
Include foods with minerals and vitamins essential for hair health.
Join a support group to connect with others experiencing hair loss.
Openly discuss your feelings about hair loss.
Consider covering up with wigs, hats, or scarves.
Be patient and avoid seeking miracle cures.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

Inflammation Of Air Passages In Lungs

Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:

If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
Regularly track your symptoms and report any changes or concerns to your healthcare provider.

Drug Warnings

Do not take Lefno-10 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefno-10 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefno-10 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefno-10 Tablet may cause dizziness, so drive with caution. Lefno-10 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

LeflunomideCorticorelin

Severe

LeflunomideMeloxicam

Severe

Drug-Drug Interactions

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LeflunomideCorticorelin

Severe

How does the drug interact with Lefno-10 Tablet:
Using Lefno-10 Tablet together with Corticorelin may raise the risk of severe infections.

How to manage the interaction:
Taking Lefno-10 Tablet with Corticorelin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact your doctor immediately. Do not stop using any medications without a doctor's advice.

LeflunomideMeloxicam

Severe

How does the drug interact with Lefno-10 Tablet:
When Meloxicam and Lefno-10 Tablet are taken together, can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Lefno-10 Tablet and Meloxicam, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.

LeflunomideLenvatinib

Severe

How does the drug interact with Lefno-10 Tablet:
Taking Lefno-10 Tablet and lenvatinib can increase the risk of liver problems.

How to manage the interaction:
Taking Lefno-10 Tablet with Lenvatinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine, liver harm, or bleeding. Do not stop using any medications without first talking to your doctor.

LeflunomideCaspofungin

Severe

How does the drug interact with Lefno-10 Tablet:
Lefno-10 Tablet can cause liver problems, and combining it with other drugs, such as binimetinib, can raise the risk.

How to manage the interaction:
There may be a possibility of interaction between Lefno-10 Tablet and Caspofungin, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact your doctor right away. These symptoms include liver problems, fever, rash, itching, loss of appetite, dark urine, stomach pain, unusual bleeding or bruising, feeling tired, and yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.

LeflunomideDivalproex

Severe

How does the drug interact with Lefno-10 Tablet:
Co-administration of divalproex and Lefno-10 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between divalproex and Lefno-10 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

LeflunomideTizanidine

Severe

How does the drug interact with Lefno-10 Tablet:
Coadministration of tizanidine and Lefno-10 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Lefno-10 Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

LeflunomideEnalapril

Severe

How does the drug interact with Lefno-10 Tablet:
Enalapril has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Lefno-10 Tablet. This effect can be seen even long after discontinuing Lefno-10 Tablet as it stays in your blood longer.

How to manage the interaction:
Although taking Enalapril together with Lefno-10 Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.

LeflunomideCabazitaxel

Severe

How does the drug interact with Lefno-10 Tablet:
The use of Lefno-10 Tablet together with Cabazitaxel may raise the risk of severe infections.

How to manage the interaction:
Taking Cabazitaxel with Lefno-10 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like infection, sore throat, diarrhea, muscle pain, weight loss, fever, or difficulty breathing, contact your doctor immediately. If you experience any discomfort or burning while urinating, let your doctor know. Do not stop using any medications without talking to your doctor.

LeflunomidePiroxicam

Severe

How does the drug interact with Lefno-10 Tablet:
Coadministration of Piroxicam and Lefno-10 Tablet can increase the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Lefno-10 Tablet and Piroxicam, you can take these medicines together if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.

LeflunomideImatinib

Severe

How does the drug interact with Lefno-10 Tablet:
Combining Imatinib with Lefno-10 Tablet may raise the risk serious infections. Rarely, these medications could potentially harm the liver.

How to manage the interaction:
Co-administration of Lefno-10 Tablet with Imatinib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms- fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in the coughing fluid, weight loss, red or irritated skin, swelling, body sores, or discomfort or burning when urinating, exhaustion, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, unusual bleeding or bruising, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
Performing yoga may also help in improving joint flexibility and pain management.
Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Acupuncture, massage and physical therapy may also be helpful.
Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
Avoid smoking and alcohol consumption.

Side Effects of Lefno-10 Tablet

Diarrhoea
Nausea
Stomach pain
Indigestion
Rash
Hair loss

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Lefno-10 Tablet work?

Lefno-10 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Does Lefno-10 Tablet cause diarrhoea?

Lefno-10 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

How long does Lefno-10 Tablet take to work?

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefno-10 Tablet . Take Lefno-10 Tablet for as long as your doctor has prescribed to treat your condition effectually.

In which conditions should I avoid taking Lefno-10 Tablet ?

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Drug-Drug Interactions Checker List

IBUPROFEN
NAPROXEN
ACETAMINOPHEN
ASPIRIN
DULOXETINE
PREDNISONE
CELECOXIB
AZATHIOPRINE
MELOXICAM
METHOTREXATE
ETANERCEPT
ADALIMUMAB
ABATACEPT
INFLIXIMAB
HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting Lefno-10 Tablet , and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness.

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.