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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

DEXAMETHASONE-4MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

About Lupidexa 4 mg Injection

Lupidexa 4 mg Injection belongs to a class of drugs called corticosteroids (hormones). When your body does not produce enough Dexamethasone, Lupidexa 4 mg Injection is often utilized to replace it. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Lupidexa 4 mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Lupidexa 4 mg Injection will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Lupidexa 4 mg Injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Lupidexa 4 mg Injection if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Lupidexa 4 mg Injection, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.

Uses of Lupidexa 4 mg Injection

Allergic or inflammatory conditions, Covid-19.

Have a query?

Directions for Use

Lupidexa 4 mg Injection will be administered by a healthcare professional; do not self-administer.

Key Benefits

Lupidexa 4 mg Injection is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Lupidexa 4 mg Injection decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Lupidexa 4 mg Injection.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before prescribing Lupidexa 4 mg Injection, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Lupidexa 4 mg Injection therapy.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Regorafenib is taken with Lupidexa 4 mg Injection 30 ml, may significantly reduce the blood levels of Regorafenib.

How to manage the interaction:
Co-administration of Regorafenib and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Desmopressin with Lupidexa 4 mg Injection 30 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Lupidexa 4 mg Injection 30 ml and Desmopressin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DexamethasoneRilpivirine
Critical
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Rilpivirine is taken with Lupidexa 4 mg Injection 30 ml, may significantly reduce the blood levels of Rilpivirine.

How to manage the interaction:
Co-administration of Rilpivirine and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Lupidexa 4 mg Injection 30 ml is taken with Ranolazine, may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Lupidexa 4 mg Injection 30 ml with Baricitinib can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Lupidexa 4 mg Injection 30 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, severe abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue the medication without consulting a doctor.
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Lupidexa 4 mg Injection 30 ml with Enoxacin can increase the risk of tendinopathy(conditions of the tendon that cause swelling and pain).

How to manage the interaction:
Taking Enoxacin with Lupidexa 4 mg Injection 30 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience symptoms like tendon pain, swelling, or difficulty moving, it's important to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
DexamethasoneOxycodone
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Oxycodone is taken with Lupidexa 4 mg Injection 30 ml, may reduce the blood levels of oxycodone.

How to manage the interaction:
There may be a possibility of interaction between Oxycodone and Lupidexa 4 mg Injection 30 ml, but it can be taken if prescribed by a doctor. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Taking Lupidexa 4 mg Injection 30 ml may reduce the blood levels of Axitinib, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, Lupidexa 4 mg Injection 30 ml can be taken with axitinib if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Taking Cladribine with Lupidexa 4 mg Injection 30 ml can increase the chances of serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Lupidexa 4 mg Injection 30 ml, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Lupidexa 4 mg Injection 30 ml is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Lupidexa 4 mg Injection 30 ml together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Lupidexa 4 mg Injection 30 ml with Caffeine may increase the side effects of Lupidexa 4 mg Injection 30 ml. Avoid consuming caffeine while taking Lupidexa 4 mg Injection 30 ml.

Diet & Lifestyle Advise

Diet & Lifestyle for Allergic or inflammatory conditions:

  • Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidants.
  • Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.
  • Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.
  • Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
  • Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.
  • Limit the consumption of foods high in sugar that may aggravate inflammation.
  • Reducing stress and having a regular sleep schedule might be beneficial.
  • Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.

 

Diet & Lifestyle for Covid-19:

  • Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.
  • Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
  • Keep a social distance and avoid social gatherings.
  • Please do not touch your eyes, nose or mouth if your hands are not clean.
  • Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
  • All surfaces should be cleaned and disinfected on a regular basis.
  • Gargling with salt water and inhaling steam would be beneficial.
  • Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
  • Never share used needles and other injections or medical devices, as they may spread viruses.
  • Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.
  • Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
  • If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
  • Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS]

All Substitutes & Brand Comparisons

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Alcohol

Safe if prescribed

It is unknown whether alcohol interacts with Lupidexa 4 mg Injection. Please consult your doctor.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor. Your doctor will then decide if the Lupidexa 4 mg Injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Inform your doctor if you are a nursing mother. The doctor will then decide if the injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Driving

Safe if prescribed

Lupidexa 4 mg Injection may cause a reduction in mental awareness; thus, avoid operating machinery or driving.

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Liver

Consult your doctor

Inform your doctor before receiving the Lupidexa 4 mg Injection if you have a history of or ongoing liver disease. Your doctor will adjust the dose of this medicine if required based on your condition.

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Kidney

Consult your doctor

Inform your doctor before receiving the Lupidexa 4 mg Injection if you have a history of or ongoing kidney disease. Your doctor may carry out extra checks while you are taking this medicine.

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Children

Safe if prescribed

Lupidexa 4 mg Injection may affect the growth of children. Therefore, your doctor may check the growth of the child regularly while using the Lupidexa 4 mg Injection.

FAQs

Lupidexa 4 mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Lupidexa 4 mg Injection because taking Lupidexa 4 mg Injection and getting immunised at the same time is not recommended.

Lupidexa 4 mg Injection is not recommended to be used in fungal infections. If you have any concerns regarding this, please discuss them with your doctor.

Lupidexa 4 mg Injection may increase the risk of Infections and infestations. Therefore, it is advised to stay away from people having chickenpox (herpes simplex), shingles (herpes zoster) or measles.

Lupidexa 4 mg Injection is approved for the treatment of coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Caution is advised if you are taking anticoagulants while on Lupidexa 4 mg Injection treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - LUP0119

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