AXITINIB

To treat your condition effectually, continue taking AXITINIB for the period that your doctor has prescribed. Avoid taking AXITINIB if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. AXITINIB may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking AXITINIB.

Drug-Drug Interactions: AXITINIB may have interaction with strong CYP3A4/5 inhibitors (clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir), strong CYP3A4/5 inducers (carbamazepine, rifampicin, phenytoin, phenobarbitone, dexamethasone).

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI perforation, lung toxicity, thyroid dysfunction, or thromboembolism before starting the treatment.

• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.

• Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of AXITINIB.
• It is advised to use contraceptive pills while using AXITINIB to prevent pregnancy.
• Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.