Lupifos 4Gm Inj

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹3950

(Inclusive of all Taxes)

₹592.5 Cashback (15%)

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Whats That

About Lupifos 4Gm Inj

Lupifos 4Gm Inj belongs to a class of drugs called antibiotics used in the treatment of bacterial infections. Lupifos 4Gm Inj is used to treat bacterial meningitis (infection of membranes protecting the brain and spinal cord), complicated urinary tract infections, bacterial infections of bones and joints, heart, lungs, central nervous system, stomach, blood, skin, and tissues below the skin. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly.

Lupifos 4Gm Inj contains Fosfomycin which works by inhibiting the formation of the bacterial cell walls (a protective covering) that is necessary for their survival. Thereby killing bacteria. Also, Lupifos 4Gm Inj decreases the attachment of bacteria to cells lining the urinary bladder.

Lupifos 4Gm Inj will be administered by a healthcare professional. Do not self-administer. You may sometimes experience gastrointestinal disturbances, taste disturbances, or injection site reactions. Most of these side effects of Lupifos 4Gm Inj do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Fosfomycin or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Lupifos 4Gm Inj. Lupifos 4Gm Inj could be used in children if prescribed by a doctor; the dose depends on the child’s age and weight. If you have experienced diarrhoea after receiving or taking antibiotics, inform your doctor before taking Lupifos 4Gm Inj. If you have kidney problems or are undergoing dialysis, inform your doctor as the dose may be reduced.

Uses of Lupifos 4Gm Inj

Bacterial infections

Directions for Use

Lupifos 4Gm Inj will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Lupifos 4Gm Inj contains Fosfomycin, a broad-spectrum antibiotic that kills gram-negative and gram-positive bacteria that grow aerobically (in the presence of oxygen) and anaerobically (in the absence of oxygen). Bacterial meningitis (infection of the membranes that protect the brain and spinal cord), complicated urinary tract infections, bacterial infections of bones and joints, heart, lungs, central nervous system, stomach, blood, skin, and tissues beneath the skin are all treated with Lupifos 4Gm Inj. Fosfomycin should be used only when other antibiotics have failed or are ineffective. Lupifos 4Gm Inj prevents bacterial cell wall formation (a protective covering required for survival). Bacteria are thus killed. Additionally, Lupifos 4Gm Inj reduces the attachment of bacteria to the cells lining the urinary bladder.

Storage

Keep Lupifos 4Gm Inj out of reach and sight of children.

Side effects of Lupifos 4Gm Inj

Taste Disturbance

Regularly brush and floss your teeth.
Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.

Low Potassium Levels In Blood

Talk to your doctor about oral potassium supplements.
Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.

Red Rash

Red rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

Inflammation Of A Vein At The Injection Site

Use a warm compress on the affected area to help reduce discomfort.
Elevate the affected limb above heart level.
Remove the IV catheter (if applicable) and reinsert at a different site.
Consult your healthcare provider if symptoms are severe or persist.

Drug Warnings

If you are allergic to Fosfomycin or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Lupifos 4Gm Inj. Lupifos 4Gm Inj may be used with caution in children if prescribed by a doctor; the dose depends on the child’s age and weight. If you had diarrhoea previously after receiving or taking antibiotics, inform your doctor before taking Lupifos 4Gm Inj. If you have kidney problems or are undergoing dialysis, inform your doctor, as the dose may be reduced.

Drug-Drug Interactions

FosfomycinCholera vaccines

Severe

FosfomycinBalsalazide

Severe

Drug-Drug Interactions

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FosfomycinCholera vaccines

Severe

How does the drug interact with Lupifos 4Gm Inj:
Co-administration of the Cholera vaccine with Lupifos 4Gm Inj may reduce the activity of the Cholera vaccine.

How to manage the interaction:
If you are currently being treated with Lupifos 4Gm Inj or have been treated within the last 14 days, inform your doctor before receiving cholera vaccine, live. Avoid receiving cholera vaccine, live until at least 14 days after you complete your antibiotic therapy to ensure adequate vaccine response.

FosfomycinBalsalazide

Severe

How does the drug interact with Lupifos 4Gm Inj:
Lupifos 4Gm Inj may reduce the effect of balsalazide when taken orally.

How to manage the interaction:
If you are supposed to take Lupifos 4Gm Inj and Balsalazide together, your doctor may adjust the dose or monitor you more frequently to use both medications safely.

FosfomycinBCG vaccine

Severe

How does the drug interact with Lupifos 4Gm Inj:
When BCG vaccine is used with Lupifos 4Gm Inj, its effectiveness may be reduced.

How to manage the interaction:
Taking Lupifos 4Gm Inj with the BCG vaccine can lead to an interaction, please consult a doctor before taking it.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Take probiotics after completing the full course of Lupifos 4Gm Inj in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like cheese, yoghurt, kombucha, sauerkraut and kimchi can help restore the intestine's good bacteria.
Include fibre-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet.
Maintain a low-sodium diet as Lupifos 4Gm Inj in injection form may increase sodium levels in the blood.
Make sure you drink plenty of water or other fluids daily while you are taking Lupifos 4Gm Inj.

Side Effects of Lupifos 4Gm Inj

Taste disturbances
Gastrointestinal disturbances
Injection site reactions

Habit Forming

No

Therapeutic Class

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Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

FOSFOMYCIN-4000MGVascular disorders of intestine

Severe

FOSFOMYCIN-4000MGCare involving dialysis

Moderate

Drug-Diseases Interactions

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FOSFOMYCIN-4000MGVascular disorders of intestine

Severe

How does the disease interact with Lupifos 4Gm Inj:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.

How to manage the interaction:
Lupifos 4Gm Inj should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).

FOSFOMYCIN-4000MGCare involving dialysis

Moderate

How does the disease interact with Lupifos 4Gm Inj:
Hemodialysis removes Lupifos 4Gm Inj, therefore it needs to be given after treatments.

How to manage the interaction:
As Lupifos 4Gm Inj is removed by hemodialysis, it should be administered after dialysis sessions.

FOSFOMYCIN-4000MGUnspecified kidney failure

Mild

How does the disease interact with Lupifos 4Gm Inj:
Lupifos 4Gm Inj is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Lupifos 4Gm Inj is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.

How to manage the interaction:
Lupifos 4Gm Inj should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.

FAQs

How does Lupifos 4Gm Inj work?

Lupifos 4Gm Inj contains Fosfomycin, which inhibits the formation of the bacterial cell wall (a protective covering) necessary for survival. Thereby killing bacteria. Also, Lupifos 4Gm Inj decreases the attachment of bacteria to cells lining the urinary bladder.

Does Lupifos 4Gm Inj cause taste disturbances?

Lupifos 4Gm Inj may cause taste disturbances as a temporary side effect. However, if the condition persists or worsens, please inform your doctor.

I am undergoing dialysis. Can I take Lupifos 4Gm Inj?

If you are undergoing dialysis or have kidney problems, inform your doctor before receiving Lupifos 4Gm Inj so that the dose may be adjusted.

Does Lupifos 4Gm Inj cause diarrhoea?

Lupifos 4Gm Inj may cause diarrhoea as a rare side effect. However, if the condition persists or worsens with fever or severe stomach pain, please consult a doctor immediately, as these might be signs of large intestine infection.

Can I take blood thinner while receiving Lupifos 4Gm Inj?

You are not recommended to take blood thinner while receiving Lupifos 4Gm Inj as co-administration of these two medicines may alter the blood thinner's ability to prevent blood from clotting. However, please consult your doctor before taking other medicines while receiving Lupifos 4Gm Inj.

Special Advise

The levels of electrolytes are regularly monitored while taking Lupifos 4Gm Inj as it may cause high sodium or low potassium levels in the blood.

Disease/Condition Glossary

Bacterial infection: It is a condition in which harmful bacteria grow in the body and cause infection. It can target any part of the body and multiple very quickly. Bacteria come in three basic shapes, namely spherical, rod or spiral-shaped. Bacteria may be gram-positive (have thick cell walls) or gram-negative (do not have cell walls). Appropriate tests are done to identify bacterial strains, and based on the results, proper medication is prescribed. Some common symptoms of bacterial infection include cough, fever and tiredness.