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Fosfomycin

About

Fosfomycin belongs to a class of drugs called 'antibiotics' used to treat or prevent bladder infections. Bladder infection is mostly caused by a bacterial infection within the bladder. Bacteria enter through the urethra and move into the bladder and cause infections.

Fosfomycin contains Fosfomycin, which inhibits the formation of the bacterial cell wall (a protective covering) necessary for survival. Thus, it kills bacteria. Also, Fosfomycin decreases the attachment of bacteria to cells lining the urinary bladder, thereby preventing bladder infection caused by E.coli bacteria. 

Take Fosfomycin as prescribed by your doctor. You are advised to take Fosfomycin for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dizziness, headache, indigestion, vulvovaginitis (swelling or infection of vulva and vagina) as side effects of Fosfomycin. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Fosfomycin, some sugars or other medicines. If you are pregnant or breastfeeding, please inform your doctor before taking Fosfomycin. Fosfomycin is not recommended for children below 12 years of age. Fosfomycin is contraindicated in patients with severe kidney problems and patients undergoing hemodialysis (a process of purifying blood by filtering out extra fluids and wastes when kidneys are not working). If you previously had diarrhoea caused by other antibiotics, inform your doctor before taking Fosfomycin.

Uses of Fosfomycin

Bladder infection

Medicinal Benefits

Fosfomycin includes Fosfomycin, a broad-spectrum antibiotic that kills gram-negative and gram-positive bacteria that grow aerobically (in the presence of oxygen) and anaerobically (in the absence of oxygen). Fosfomycin prevents the formation of the necessary bacterial cell wall (a protective covering) for survival. As a result, it kills bacteria. Additionally, Fosfomycin inhibits bacterial attachment to cells lining the urinary bladder, preventing bladder infection caused by E.coli bacteria.

Directions for Use

Fosfomycin should be taken on an empty stomach, preferably before bedtime after emptying the bladder or take it as advised by the doctor. Dissolve the contents of the sachet in a glass of water, stir to dissolve and drink immediately. Do not use hot water.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Fosfomycin

  • Dizziness
  • Headache
  • Indigestion
  • Vulvovaginitis (swelling or infection of vulva and vagina) 

In-Depth Precautions and Warning

Drug Warnings

Please tell your doctor if you are allergic to Fosfomycin, some sugars or other medicines. If you are pregnant or breastfeeding, please inform your doctor before taking Fosfomycin. Fosfomycin is not recommended for children below 12 years of age. Fosfomycin is contraindicated in patients with severe kidney problems and patients undergoing hemodialysis (a process of purifying blood by filtering out extra fluids and wastes when kidneys are not working). Contact your doctor immediately if you notice blood in the stools or have severe stomach pain with diarrhoea. If you previously had diarrhoea caused by other antibiotics, inform your doctor before taking Fosfomycin.

Drug Interactions

Drug-Drug Interaction: Fosfomycin may interact with medicines used to prevent nausea and vomiting (metoclopramide).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have previously had diarrhoea caused by other antibiotics or severe kidney problems, inform your doctor before taking Fosfomycin.

Drug-Drug Interactions Checker List:

  • METOCLOPRAMIDE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      The interaction of alcohol with Fosfomycin is unknown. However, limit or avoid consumption of alcohol while taking Fosfomycin.

    • Safety Warning

      Pregnancy

      caution

      Fosfomycin is a category B pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Therefore, please inform your doctor if you are pregnant or planning pregnancy before taking Fosfomycin.

    • Safety Warning

      Breast Feeding

      caution

      Small amounts of Fosfomycin are excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

    • Safety Warning

      Driving

      caution

      Fosfomycin may cause dizziness or tiredness in some people. Therefore, avoid driving if you experience any of these symptoms after taking Fosfomycin.

    • Safety Warning

      Liver

      caution

      Limited information is available on the effect of Fosfomycin in patients with liver disease. Therefore, inform your doctor if you have any liver diseases/conditions before taking this medicine.

    • Safety Warning

      Kidney

      caution

      Fosfomycin is not recommended if you have severe kidney problems or are undergoing hemodialysis. Inform your doctor if you have any Kidney problems before taking Fosfomycin.

    • Safety Warning

      Children

      unsafe

      Fosfomycin is not recommended for children below 12 years of age as the safety and effectiveness were not established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Avoid alcohol, soda, coffee, tea, and artificial sweeteners, as they may cause bladder irritation.
    • Drink plenty of water or other fluids daily while taking Fosfomycin to flush out the bacteria.
    • Avoid spicy foods and citrus fruits (lemons, oranges, grapefruits) as they may irritate the bladder.
    • Eat foods antioxidant-rich foods such as blueberries, cranberries, tomatoes, spinach, broccoli, and plain greek yoghurt.
    • Take probiotics after completing the entire course of Fosfomycin to restore some good bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like cheese, yoghurt, kombucha, sauerkraut and kimchi can help restore the intestine's good bacteria. 
    • Include fibre-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as brown rice and whole-grain bread should be included in your diet. 

    Special Advise

    • Please consult your doctor if the symptoms do not improve after 3 days of treatment with Fosfomycin.

    Patients Concern

    Disease/Condition Glossary

    Bladder infection: This is caused primarily by a bacterial infection within the bladder. The most common type of urinary tract infection is a bladder infection. Bacteria enter the urethra, migrate to the bladder, and cause infections. Cloudy or bloody urine, urinating more frequently than usual, pain or burning when urinating, cramping or pressure in the lower back or lower abdomen, foul-smelling urine, or a frequent sensation of urge to urinate are all symptoms. Bladder infections can also result in mild back pain, which is linked to a kidney infection.

    FAQs

    Fosfomycin contains Fosfomycin, which inhibits the formation of the bacterial cell wall (a protective covering) necessary for their survival. Thus, it kills bacteria. Also, Fosfomycin decreases the attachment of bacteria to cells lining the urinary bladder.

    Fosfomycin is not recommended in patients undergoing hemodialysis (a process of purifying blood by filtering out extra fluids and wastes when kidneys are not working) as the excretion of Fosfomycin may be reduced in such patients leading to the accumulation of Fosfomycin in the body. Therefore, please inform your doctor if you are undergoing hemodialysis before taking Fosfomycin so that alternative medicine may be prescribed.

    Yes, Fosfomycin may cause headaches as a common side effect. However, if the condition persists or worsens, please consult a doctor.

    You are not recommended to take Fosfomycin with metoclopramide as co-administration of these two medicines may reduce the absorption of Fosfomycin. However, please consult your doctor before taking Fosfomycin with other medicines.

    You are not recommended to stop taking Fosfomycin without consulting your doctor, as it may worsen the infection or cause recurring symptoms. Therefore, complete the full course of antibiotics and take Fosfomycin for as long as your doctor has prescribed it, and if you experience any difficulty while taking Fosfomycin, please consult your doctor.

    Available Medicines for

    Fosfomycin

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