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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lynparza 150Mg Tablet

Lynparza 150Mg Tablet belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop using the Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. While on Lynparza 150Mg Tablet treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Lynparza 150Mg Tablet

Cancer (Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer)

Directions for Use

Swallow it as a whole with water; do not crush or chew it.

Medicinal Benefits

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Thus, it treats various cancers, including Ovarian, breast, pancreatic, and prostate. It can be used alone or with other chemotherapy drugs, depending on your type of cancer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from any medical illness. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. Do not start Lynparza 150Mg Tablet unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Lynparza 150Mg Tablet and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Lynparza 150Mg Tablet.

Drug-Drug Interactions

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OlaparibEnzalutamide
Severe
OlaparibAmprenavir
Severe

Drug-Drug Interactions

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OlaparibEnzalutamide
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Co-administration of Enzalutamide and Lynparza 150 mg Tablet may decrease the blood levels of Lynparza 150 mg Tablet, which may make Lynparza 150 mg Tablet less effective in treating your condition.

How to manage the interaction:
Although taking Enzalutamide and Lynparza 150 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
OlaparibAmprenavir
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Amprenavir and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects of Lynparza 150 mg Tablet.

How to manage the interaction:
Combining Amprenavir and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Using Darunavir and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Darunavir and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Using Posaconazole and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort.

How to manage the interaction:
Although there is an interaction between posaconazole and Lynparza 150 mg Tablet, it can be taken if advised by a doctor. However, if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Using Crizotinib and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Crizotinib and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Aprepitant may significantly raise Lynparza 150 mg Tablet levels in the blood. This has a tendency to intensify side effects.

How to manage the interaction:
Despite the fact that Aprepitant and naloxegol interact, it can be taken if prescribed by a doctor. If you have paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or pain while urinating , consult a doctor. Do not discontinue any medications without consulting a doctor.
OlaparibNefazodone
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Nefazodone and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Nefazodone and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
OlaparibFosphenytoin
Severe
How does the drug interact with Lynparza 150 mg Tablet:
When Lynparza 150 mg Tablet is taken with Fosphenytoin, it can cause Lynparza 150 mg Tablet to be broken down faster in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Lynparza 150 mg Tablet with Fosphenytoin can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
OlaparibEtravirine
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Etravirine together with Lynparza 150 mg Tablet can reduce the blood levels of Lynparza 150 mg Tablet.

How to manage the interaction:
Although taking Lynparza 150 mg Tablet and Etravirine together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.
OlaparibMibefradil
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Mibefradil and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Mibefradil and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Lynparza 150Mg Tablet.

Yes, Lynparza 150Mg Tablet can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Yes, Olaparib was generally a well-tolerated medication. Take Lynparza 150Mg Tablet pills exactly as directed by your healthcare provider. Do not change your dose or stop taking Lynparza 150Mg Tablet unless your healthcare physician instructs you. If you encounter side symptoms, your healthcare provider may temporarily discontinue your Lynparza 150Mg Tablet therapy or adjust your Lynparza 150Mg Tablet dose.

Drug-Drug Interactions Checker List

  • AMPRENAVIR
  • DARUNAVIR
  • APREPITANT
  • BCG VACCINE
  • DENGUE VACCINE
  • MUMPS (LIVE ATTENUATED)
  • CIPROFLOXACIN
  • FLUCONAZOLE
  • ITRACONAZOLE

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Lynparza 150Mg Tablet.
  • Lynparza 150Mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Lynparza 150Mg Tablet.
  • Monitor complete blood count for cytopenia at baseline and monthly for clinically significant changes during treatment.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Lynparza 150Mg Tablet treatment and, when appropriate, until recovery is achieved.
  • Do not donate sperm during treatment with Lynparza 150Mg Tablet for three months after your last dose.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Ovarian cancer: Ovarian cancer begins in the ovaries (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Breast cancer: Breast cancer is a type of cancer that develops in breast cells stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other body parts. Symptoms of breast cancer include a lump in the breast or tissue thickening, which feels different than the normal surrounding tissues, breast pain, redness, swelling, and nipple discharge other than breast milk.

Prostate cancer: Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen. Inability to urinate easily, pain, numbness, or sexual issues are among the symptoms. For men, it is the most typical type of cancer. Although the exact cause of prostate cancer is unknown, it may be brought on by family history, chemical exposure, or both. Prostate cancer risk factors include a family history of the disease, advanced age, obesity, and genetic changes.

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