Macirol Tablet 10's

₹1750

(Inclusive of all Taxes)

₹262.5 Cashback (15%)

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Veda Maddala , M Pharmacy

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Whats That

About Macirol Tablet

Macirol Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat high blood pressure in the lungs' arteries (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping blood to the whole body. Pulmonary hypertension affects arteries in the lungs and the right side of the heart.

Macirol Tablet contains 'macitentan', which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Macirol Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply, thus lowering blood pressure.

Take Macirol Tablet as prescribed by your doctor. Your dose and duration of Macirol Tablet will be advised by your doctor, depending upon your medical condition. In some cases, you may experience headaches, inflammation of the airways, and oedema. Most of these side effects of Macirol Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Please inform your doctor if you are using any prescription, or non-prescription drugs, including vitamins and herbal products. Before starting Macirol Tablet , let your doctor know if you have allergic reactions to Macirol Tablet or other medicines. Inform your doctor if you have low blood pressure, lung, heart, kidney, liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Macirol Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with Macirol Tablet as it may increase the risk of low blood pressure.

Uses of Macirol Tablet

Pulmonary arterial hypertension (PAH) in adults.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Macirol Tablet is an anti-hypertensive medicine that treats high blood pressure in the lungs' arteries (pulmonary arterial hypertension (PAH)). It contains 'Macitentan,' which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower making the heart work harder to pump blood through them. Macirol Tablet widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

Storage

Keep out of sight and reach of children.

Side effects of Macirol Tablet

Pink Eye

Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
A warm compress and washing the eyes with water can help with crusting on the eyelids.
Avoid wearing contact lens until you feel better; use spectacles instead.
Do not rub the eyes.
Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Irritable bowel syndrome (Irritable Bowel Syndrome (IBS))

Increase fibre intake to alleviate constipation.
Track your food intake to identify trigger foods.
Limit caffeine, fatty foods, and gas-producing foods.
Explore probiotics or a low fermented sugar diet for relief.
Regular exercise and stress management through therapy can help.
Stay hydrated by drinking plenty of water.

Gallstones

Your doctor may recommend medications to dissolve the small gallstones (like ursodiol) or use shock waves to break up the stones.
Try to eat regular meals because skipping meals can increase the risk of gallstones by making your gallbladder work less efficiently.
Eat breakfast soon after you wake up, as cholesterol in bile is highest in the morning.
If you are overweight, losing weight gradually can help lower the chance of developing gallstones.
Include plenty of fresh vegetables and fruits in your diet.
Base your meals around starchy foods like bread, pasta, rice, and potatoes, especially whole grain or high-fibre varieties.

Windpipe Infection

If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
Drink lots of water to thin mucus and help with coughing.
Get enough sleep to allow the body to heal.
Suck on lozenges to soothe sore throat.
Quit smoking and alcohol consumption.

Inflammation Of Tonsils

High Levels Of Urea In The Blood

Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
Severe cases may require kidney transplant or dialysis.

Drug Warnings

Please inform your doctor beforehand if you are allergic to Macirol Tablet or other medicines. Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting Macirol Tablet . Macirol Tablet is contraindicated during pregnancy since it harms the foetus. Please get a pregnancy test done before starting Macirol Tablet . You should get a negative pregnancy test for sure before using Macirol Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Macirol Tablet to avoid pregnancy. Consult your doctor before using Macirol Tablet if you are a breastfeeding mother. Complete the course strictly as the doctor advises, even if you feel better, to avoid the recurrence of the disease. Do not drive or operate machinery since Macirol Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Macirol Tablet as it may increase the risk of low blood pressure. Macirol Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

MacitentanAtazanavir

Severe

MacitentanSaquinavir

Severe

Drug-Drug Interactions

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MacitentanAtazanavir

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Atazanavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
Although there is a possible interaction between Macirol Tablet and Atazanavir, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, it's important to let your doctor know. Do not stop using any medications without first talking to your doctor.

MacitentanSaquinavir

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Saquinavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
Co-administration of Macirol Tablet with Saquinavir can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

MacitentanEnzalutamide

Severe

How does the drug interact with Macirol Tablet:
Taking Enzalutamide with Macirol Tablet may decrease the blood levels of Macirol Tablet, which may make Macirol Tablet less effective in treating your condition.

How to manage the interaction:
Although taking Enzalutamide and Macirol Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms like- watery eyes, a runny nose, sneezing, yawning, sweating heavily, fever, chills, flushing, restlessness, irritability, anxiety, eye problems, shaking, rapid heartbeat, body aches, involuntary twitching and kicking, stomach pain, diarrhea, consult the doctor. Do not discontinue any medications without a doctor's advice.

MacitentanFosamprenavir

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Fosamprenavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
Co-administration of Macirol Tablet with Fosamprenavir can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, it's important to let your doctor know. Do not stop using any medications without first talking to your doctor.

MacitentanVoriconazole

Severe

How does the drug interact with Macirol Tablet:
Using Macirol Tablet together with Voriconazole can significantly increase the risk of liver problems.

How to manage the interaction:
Although taking Voriconazole and Macirol Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, joint pain or swelling, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

MacitentanItraconazole

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with itraconazole may increase the blood levels of Macirol Tablet that increases risk of side effects.

How to manage the interaction:
Itraconazole and Macirol Tablet may interact, but if a doctor prescribes them, you can still take them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, seek medical attention. Never discontinue taking a medication without consulting a doctor.

MacitentanRitonavir

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Ritonavir may increase the blood levels of Macirol Tablet.

How to manage the interaction:
There may be a possibility of interaction between Macirol Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes, contact your doctor immediately. Do not stop using any medications without talking to a doctor.

MacitentanCeritinib

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Ceritinib may increase the blood levels of Macirol Tablet.

How to manage the interaction:
Although there is a interaction between Macirol Tablet and ceritinib, but it can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakess, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

MacitentanLomitapide

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Lomitapide affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Macirol Tablet and Lomitapide, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

MacitentanPrimidone

Severe

How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Primidone may significantly reduce the blood levels of Macirol Tablet, which may make the medication less effective.

How to manage the interaction:
Co-administration of Primidone with Macirol Tablet can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
Keep your weight under control with a BMI of 19.5-24.9.
Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
Try to include heart-healthy omega-3-fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
Be mindful of salt; consume no more than 2,300 mg each day.
Limit or avoid alcohol consumption.
Quitting smoking is the best strategy to lower the risk of heart disease.

Side Effects of Macirol Tablet

Anaemia (low number of red blood cells) or reduced haemoglobin
Headache
Bronchitis (inflammation of the airways)
Nasopharyngitis (inflammation of the throat and nasal passages)
Oedema (swelling), especially of the ankles and feet

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

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Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:41 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Macirol Tablet work?

Macirol Tablet consists of Macitentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.

Can I take Macirol Tablet on my own?

No, it is a prescribed drug given by a physician for treating specific medical conditions. Taking it on your own can cause unwanted side effects.

Can I stop using Macirol Tablet when my symptoms are relieved?

Even if you feel good, do not stop using the $ name. It should be used as prescribed by your doctor to prevent the recurrence of symptoms and worsening of the disease.

In which conditions, should I stay cautious while using Macirol Tablet ?

Macirol Tablet should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention), and hypotension (low blood pressure).

What are the common symptoms of pulmonary hypertension?

Shortness of breath, weariness (tiredness), feeling faint or dizzy, chest discomfort (angina), a rapid heartbeat (palpitations), and swelling (oedema) in the legs, ankles, feet, or tummy are all common symptoms of pulmonary hypertension (abdomen).

Is there a cure for pulmonary hypertension?

Although pulmonary hypertension cannot be cured, there are treatments that can help you control your symptoms and manage your condition. It may be possible to prevent irreversible damage to your pulmonary arteries (which are the blood vessels that supply your lungs) if the cause is detected and treated early.

Drug-Drug Interactions Checker List

RIFAMPICIN
CLARITHROMYCIN
PHENYTOIN
CARBAMAZEPINE
RITONAVIR
SAQUINAVIR
FLUCONAZOLE
ITRACONAZOLE
CYCLOSPORINE
DILTIAZEM
VERAPAMIL

Special Advise

Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor.
Your doctor may ask you to undergo a blood test whether you have anaemia (a reduced number of red blood cells).
If you have diabetes, using Macirol Tablet may affect your blood sugar levels. Inform your doctor so that you may adjust your diabetes medication accordingly.
Your dietician may prescribe you a suitable exercise program and diet to manage your blood pressure.
Your doctor may also suggest liver function tests.

Disease/Condition Glossary

Pulmonary Arterial Hypertension: It is referred to as high blood pressure in the blood vessels (the pulmonary arteries) that carry blood from the heart to the lungs. It's a serious condition that can harm the heart's right side. The walls of the pulmonary arteries thicken and stiffen, making it difficult for blood to flow through. Because of the reduced blood flow, the right side of the heart has a harder time pumping blood through the arteries which may lead to heart failure. The common symptoms of pulmonary hypertension are shortness of breath, dizziness, palpitations, and chest pressure. It can affect people of all ages, but it is more common in people who already have a heart or lung problem.