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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

About MEDITREX 5MG TABLET

MEDITREX 5MG TABLET belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. MEDITREX 5MG TABLET is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

MEDITREX 5MG TABLET contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, MEDITREX 5MG TABLET prevents and stops the growth of cancer cells, thereby helps treat cancer. MEDITREX 5MG TABLET treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, MEDITREX 5MG TABLET may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take MEDITREX 5MG TABLET exactly as prescribed by the doctor; daily intake of MEDITREX 5MG TABLET could lead to serious toxic effects. Do not take MEDITREX 5MG TABLET if you are pregnant or breastfeeding. MEDITREX 5MG TABLET may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with MEDITREX 5MG TABLET. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

METHOTREXATE-5MG

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of MEDITREX 5MG TABLET

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Medicinal Benefits

MEDITREX 5MG TABLET belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. MEDITREX 5MG TABLET helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. MEDITREX 5MG TABLET treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. MEDITREX 5MG TABLET is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). MEDITREX 5MG TABLET prevents and stops the growth of cancer cells by interfering with DNA production. MEDITREX 5MG TABLET may also be used to treat inflammatory bowel disease.

Side Effects of MEDITREX 5MG TABLET

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Directions for Use

MEDITREX 5MG TABLET should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take MEDITREX 5MG TABLET if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking MEDITREX 5MG TABLET if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. MEDITREX 5MG TABLET may cause dizziness and fatigue, so drive only if you are alert. Take MEDITREX 5MG TABLET exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking MEDITREX 5MG TABLET and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Therapeutic Class

IMMUNOSUPPRESSANTS

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateDiclofenac
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of Etretinate with MEDITREX 5MG TABLET may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with MEDITREX 5MG TABLET is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateDiclofenac
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of MEDITREX 5MG TABLET with diclofenac can increase the levels and effects of MEDITREX 5MG TABLET. This can lead to increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between MEDITREX 5MG TABLET and diclofenac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, loss of hunger, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, fits, infection, fever, chills, body aches, sore throat or muscle weakness, consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateAcitretin
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of Acitretin with MEDITREX 5MG TABLET may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with MEDITREX 5MG TABLET, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateTenofovir alafenamide
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Combine use of tenofovir alafenamide with MEDITREX 5MG TABLET may increase the levels or side effects of tenofovir alafenamide.

How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and MEDITREX 5MG TABLET, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.
MethotrexateBaricitinib
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of Baricitinib and MEDITREX 5MG TABLET can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and MEDITREX 5MG TABLET, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateEsomeprazole
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of MEDITREX 5MG TABLET and esomeprazole can increase the blood levels and side effects of MEDITREX 5MG TABLET.

How to manage the interaction:
Although taking Esomeprazole with MEDITREX 5MG TABLET can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
MethotrexateEntecavir
Severe
How does the drug interact with MEDITREX 5MG TABLET:
The combined use of entecavir with MEDITREX 5MG TABLET may increase levels of Entecavir, and increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between entecavir and MEDITREX 5MG TABLET, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateCladribine
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of MEDITREX 5MG TABLET with cladribine can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cladribine and MEDITREX 5MG TABLET, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Taking Human immunoglobulin with MEDITREX 5MG TABLET may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with MEDITREX 5MG TABLET together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethotrexateLansoprazole
Severe
How does the drug interact with MEDITREX 5MG TABLET:
Co-administration of MEDITREX 5MG TABLET with Lansoprazole can increase the blood levels and side effects of MEDITREX 5MG TABLET.

How to manage the interaction:
Although there is a possible interaction between MEDITREX 5MG TABLET and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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METHOTREXATE-5MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-5MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of MEDITREX 5MG TABLET. Avoid taking caffeine while taking MEDITREX 5MG TABLET. This can increase the risk or severity of side effects.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with MEDITREX 5MG TABLET and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as MEDITREX 5MG TABLET may cause infertility.
  • MEDITREX 5MG TABLET may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of MEDITREX 5MG TABLET, call your doctor and ask if you should take the missed dose or not.

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back, and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin, and pain.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

MEDITREX 5MG TABLET Substitute

Substitutes safety advice
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