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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Whats That

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Composition :

METHOTREXATE-5MG

Manufacturer/Marketer :

Indiabulls Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Trexo 5 Tablet

Trexo 5 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Trexo 5 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Trexo 5 Tablet contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Trexo 5 Tablet prevents and stops the growth of cancer cells, thereby helps treat cancer. Trexo 5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Trexo 5 Tablet may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Trexo 5 Tablet exactly as prescribed by the doctor; daily intake of Trexo 5 Tablet could lead to serious toxic effects. Do not take Trexo 5 Tablet if you are pregnant or breastfeeding. Trexo 5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Trexo 5 Tablet . Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Trexo 5 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Directions for Use

Trexo 5 Tablet should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Medicinal Benefits

Trexo 5 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Trexo 5 Tablet helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Trexo 5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Trexo 5 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Trexo 5 Tablet prevents and stops the growth of cancer cells by interfering with DNA production. Trexo 5 Tablet may also be used to treat inflammatory bowel disease.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Trexo 5 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Trexo 5 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Trexo 5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Take Trexo 5 Tablet exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Trexo 5 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Trexo 5 Tablet:
Co-administration of Etretinate with Trexo 5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Trexo 5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with cloxacillin can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cloxacillin and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, Consult a doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with dicloxacillin can increase the levels and effects of Trexo 5 Tablet. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateNitrous oxide
Severe
How does the drug interact with Trexo 5 Tablet:
Combine use of nitrous oxide with Trexo 5 Tablet may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.
How does the drug interact with Trexo 5 Tablet:
Coadministration of Trexo 5 Tablet with ibuprofen can increase the effect and side effects of Trexo 5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and ibuprofen, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with Lansoprazole can increase the blood levels and side effects of Trexo 5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trexo 5 Tablet:
Coadministration of leflunomide with Trexo 5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Trexo 5 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trexo 5 Tablet:
Co-administration of Trexo 5 Tablet with amoxicillin can increase the levels and side effects of Trexo 5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Trexo 5 Tablet and amoxicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Trexo 5 Tablet:
Co-administration of Benzylpenicillin with Trexo 5 Tablet may increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction, Trexo 5 Tablet can be taken with Benzylpenicillin if prescribed by the doctor. Consult the prescriber if you experience any symptoms such as fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body aches. Contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Trexo 5 Tablet:
Combine use of entecavir with Trexo 5 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Trexo 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Trexo 5 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

Trexo 5 Tablet works by suppressing the overactive immune system that is responsible for causing psoriasis. Trexo 5 Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Trexo 5 Tablet . Stop taking Trexo 5 Tablet and consult your doctor if you have diarrhoea. Do not take anti-diarrheal medicine on your own.

Trexo 5 Tablet can affect egg and sperm production and could lead to birth defects. Women of child-bearing potential and men using Trexo 5 Tablet must use effective contraception while on treatment with Trexo 5 Tablet and for at least six months after stopping the treatment. Trexo 5 Tablet can lead to infertility. Therefore male patients are advised to talk with their doctor regarding the possibility of sperm preservation before starting the treatment with Trexo 5 Tablet .

Trexo 5 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Trexo 5 Tablet may cause mouth sores. Stop taking Trexo 5 Tablet and consult your doctor if you have sores in the mouth. Your doctor may recommend folate supplements to treat mouth sores.

Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with Trexo 5 Tablet and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as Trexo 5 Tablet may cause infertility.
  • Trexo 5 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of Trexo 5 Tablet , call your doctor and ask if you should take the missed dose or not.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back, and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin, and pain.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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