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Mesna 200 mg Injection 2 ml

Mesna 200 mg Injection 2 ml

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Prescription drug
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Composition

MESNA-200MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Mesna 200 mg Injection 2 ml

Mesna 200 mg Injection 2 ml belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our bodies degrade the anticancer drug (ifosfamide) to generate a compound (acrolein) that can injure and irritate the bladder. Mesna 200 mg Injection 2 ml decreases the risk of bladder irritation and bleeding caused by other anti-cancer drugs.

Mesna 200 mg Injection 2 ml contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Mesna 200 mg Injection 2 ml will be administered to your vein by a trained healthcare professional; hence, do not self-administer. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms, fever, and injection site reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Mesna 200 mg Injection 2 ml is not recommended if you are allergic to it or any of its ingredients. An effective birth control measure should be taken to avoid pregnancy in women of a mother-bearing you’re your doctor may suggest regular urine and blood test while receiving Mesna 200 mg Injection 2 ml to monitor your CBC (blood cell count). Mesna 200 mg Injection 2 ml is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is advised to drink at least 1-2 litres of fluid daily while receiving Mesna 200 mg Injection 2 ml. This medicine should be avoided in pregnant and breastfeeding populations due to serious side effects; hence inform your doctor before administration.

Uses of Mesna 200 mg Injection 2 ml

Ifosfamide-induced hemorrhagic cystitis. 

Medicinal Benefits

Mesna 200 mg Injection 2 ml belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder by receiving anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Directions for Use

Mesna 200 mg Injection 2 ml will be administered by a healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mesna 200 mg Injection 2 ml

  • Nausea
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Lethargy
  • Rash
  • Diarrhea
  • Lightheadedness
  • Abdominal pain
  • Flu-like symptoms
  • Fever
  • Injection site reactions

Drug Warnings

Do not take this injection if you are allergic to Mesna 200 mg Injection 2 ml or any of its ingredients. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a three-month gap between your last dose of Mesna 200 mg Injection 2 ml and your next pregnancy. Regular urine and blood test should be done while receiving Mesna 200 mg Injection 2 ml to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery. 

Drug Interactions

Drug-Disease Interactions: Mesna 200 mg Injection 2 ml is known to interact in patients with an autoimmune disorder like rheumatoid arthritis (pain and inflammation in the joints), systemic lupus erythematosus (a severe form of lupus in which pain and fatigue occur in joints), or nephritis (a type of kidney problem).

Drug-Food Interactions: Inform your doctor about all vitamins, minerals you are taking.

Drug-Drug Interactions: Mesna 200 mg Injection 2 ml is known to interact with anticoagulants (anisindione, dicumarol, warfarin).

Drug-Drug Interactions Checker List

  • WARFARIN
  • DICUMAROL
  • ANISINDIONE

Habit Forming

No

Diet & Lifestyle Advise

  • Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
  • Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
  • Sleep at least 8 hours a day and take plenty of rest.
  • Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Special Advise

  • Regular blood and urine test are required while receiving Mesna 200 mg Injection 2 ml.
  • Mesna 200 mg Injection 2 ml may interfere with enzymatic creatinine phosphokinase (CPK) activity tests that use a thiol compound (N-acetylcysteine) for CPK reactivation. This may result in a falsely low CPK level. Inform your doctor about the use of Mesna 200 mg Injection 2 ml.
  • Mesna 200 mg Injection 2 ml may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Hence inform your doctor or laboratory personnel about the use of this medicine.

Disease/Condition Glossary

Ifosfamide-induced Hemorrhagic cystitis: It is a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It occurs when an individual undergoes planned chemotherapy (for cancer treatment). During chemotherapy, an anticancer medication called 'ifosfamide' causes inflammation and bleeding of the bladder, which is passed into the urine. The colour of urine may vary from pink to red in colour.  

Country of origin

INDIA

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044.
Other Info - MES0079

FAQs

Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Mesna 200 mg Injection 2 ml works by making this natural chemical less harmful or toxic. However, Mesna 200 mg Injection 2 ml does not change ifosfamide's anti-cancer effects.
No, Mesna 200 mg Injection 2 ml should not be taken with an anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.
An autoimmune disorder is a condition in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage. Some autoimmune disorders are rheumatoid arthritis, systemic lupus erythematosus or nephritis.
Please inform your doctor if you observe any change in the urine colour (like if you have red/pink-coloured urine).
In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Mesna 200 mg Injection 2 ml as it may lead to serious side effects.

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Pregnancy

Unsafe

Mesna 200 mg Injection 2 ml is not recommended to be used in pregnancy as it may cause serious side effects. Use effective birth control measures before starting the treatment with Ifosamide and for 3 months after completing the treatment. If you get pregnant while you are receiving Mesna 200 mg Injection 2 ml, inform your doctor.

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Breast Feeding

Unsafe

Mesna 200 mg Injection 2 ml should not be used if you are breastfeeding as it is known to pass through the breast milk and harm your infant. Do not breastfeed for at least one week following your last dosage of mesna or ifosfamide.

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Driving

Unsafe

Mesna 200 mg Injection 2 ml is known to cause blurred vision and drowsiness. So, do not drive or operate machinery, which requires mental alertness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before receiving Mesna 200 mg Injection 2 ml.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before receiving Mesna 200 mg Injection 2 ml. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

The safety and efficacy of Mesna 200 mg Injection 2 ml in children have not been established. Moreover, Mesna 200 mg Injection 2 ml contains benzyl alcohol, which is known to cause a gasping syndrome in children. Hence, use is not recommended.

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