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Reviewed By Sunny S , MBBS
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Manufacturer/Marketer

Novartis India Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Methergin Injection 1 ml

Methergin Injection 1 ml belongs to the class of medication called 'ergot alkaloids' or 'uterotonic' primarily used to prevent and stop heavy bleeding (postpartum-third stage of labour bleeding) after childbirth or after a miscarriage in cesarean section. Besides this, it is also used to improve uterine contraction (antepartum) and produce uterine contraction during the third stage of labor (postpartum). Postpartum haemorrhage is heavy bleeding (more than normal) after the birth of the baby.

Methergin Injection 1 ml contains a semi-synthetic ergot alkaloid 'Methylergometrine', that stimulates uterine muscles and increases the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increasing contractions and producing labour. As a result, these increased uterine contractions help in the child's delivery and substantially reduce excessive uterine bleeding. 

Methergin Injection 1 ml will be administered by a healthcare professional. Do not self-administer. The most common side effects of Methergin Injection 1 ml are nausea, vomiting, stomach pain, and mild headache in some cases. Most of these side effects of Methergin Injection 1 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you ever had surgery on the uterus, cesarean, or premature labour, please inform your doctor to avoid any complications. If you have been given prostaglandins, then do not take Methergin Injection 1 ml; if both medicines are taken together, it can increase the contractions. Methergin Injection 1 ml should not be used for a prolonged time if the contractions do not increase or have severe pre-eclamptic toxemia (high blood pressure, protein in the urine, and swelling), blood or heart circulation problem. 

Uses of Methergin Injection 1 ml

Postpartum haemorrhage

Directions for Use

Methergin Injection 1 ml will be administered by a healthcare professional under strict medical supervision. Do not self-administer.

Medicinal Benefits

Methergin Injection 1 ml contains a semi-synthetic ergot alkaloid 'Methylergometrine' primarily used to stop heavy bleeding postpartum, i.e. third stage of labour bleeding after childbirth or after a miscarriage in cesarean section. Additionally, it plays a significant role in birth by increasing uterus contractions and inducing labour in pregnant women. Methergin Injection 1 ml works by stimulating uterine muscles and expanding the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increases the contraction,s and hence induces labour. As a result, these increased uterine contractions help deliver the child and substantially reduce excessive uterine bleeding.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Methergin Injection 1 ml

  • Nausea
  • Vomiting
  • Headache
  • Stomach pain

Drug Warnings

Do not take Methergin Injection 1 ml if you are allergic to Methergin Injection 1 ml or any of its ingredients. Increasing the dose of Methergin Injection 1 ml can be harmful if your womb already has too strong contractions, any obstructions in the pathway that might prevent the delivery or if the baby is not receiving a sufficient oxygen supply. Also, the use of Methergin Injection 1 ml is not advisable if the baby is wrongly positioned in the birth canal, the baby’s head is too large to fit through the pelvis, the placenta lies near the neck of the womb, the placenta separates from the womb before birth, the womb is over-extended and likely to tear (in case you are carrying more than one baby). If you have been given prostaglandins, do not use Methergin Injection 1 ml within 6 hours as both medications, if taken together, can increase the contractions. Methergin Injection 1 ml should not be used for a prolonged time if the contractions do not increase or if you have severe pre-eclamptic toxaemia (high blood pressure, protein in the urine, and swelling) or blood or heart circulation problems.

Drug-Drug Interactions

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MethylergometrineKetoconazole
Critical
MethylergometrineSumatriptan
Critical

Drug-Drug Interactions

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MethylergometrineKetoconazole
Critical
How does the drug interact with Methergin Injection:
Using Ketoconazole with Methergin Injection can increase the concentration of Methergin Injection, which may lead to side effects.

How to manage the interaction:
Taking Ketoconazole with Methergin Injection is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineSumatriptan
Critical
How does the drug interact with Methergin Injection:
Coadministration of Sumatriptan with Methergin Injection can reduce the blood flow and increase the risk of high blood pressure or heart-related problems.

How to manage the interaction:
Taking Sumatriptan with Methergin Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MethylergometrineVoriconazole
Critical
How does the drug interact with Methergin Injection:
Coadministration of Methergin Injection with Voriconazole may increase the blood level of Methergin Injection.

How to manage the interaction:
Although Methergin Injection with Voriconazole can cause an interaction, they can be taken if prescribed by a doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineKetoconazole
Critical
How does the drug interact with Methergin Injection:
Using Ketoconazole with Methergin Injection can increase the concentration of Methergin Injection, which may lead to side effects.

How to manage the interaction:
Taking Ketoconazole with Methergin Injection can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineItraconazole
Critical
How does the drug interact with Methergin Injection:
Co-administration of Methergin Injection and Itraconazole may increase the blood levels of Methergin Injection.

How to manage the interaction:
Methergin Injection and itraconazole may interact, but if prescribed by a doctor, they can be used together. Do not discontinue any medications without first consulting your doctor.
MethylergometrineClarithromycin
Critical
How does the drug interact with Methergin Injection:
When Methergin Injection is taken with Clarithromycin, the amount of Methergin Injection in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Clarithromycin with Methergin Injection is generally avoided as it can lead to an interaction, it can be taken only when advised by a doctor. Do not stop using any medications without a doctor's advice.
MethylergometrineGlyceryl trinitrate
Critical
How does the drug interact with Methergin Injection:
Coadministration of Methergin Injection with Glyceryl trinitrate can increase the levels and side effects of Methergin Injection.

How to manage the interaction:
Taking Methergin Injection with Glyceryl trinitrate is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
MethylergometrineRitonavir
Critical
How does the drug interact with Methergin Injection:
Taking Methergin Injection with Ritonavir can significantly increase the blood levels and effects of Methergin Injection.

How to manage the interaction:
Taking Methergin Injection with Ritonavir is not recommended, but can be taken together if prescribed by a doctor. In case you experience any side effects like severe abdominal discomfort, nausea, vomiting, tingling or numbness, weakness or pain in the muscles, pale skin, blue or purple discoloration on fingers or toes, tightness or pain in the chest, irregular heartbeat, intense headache, breathing difficulties, confusion, or slurred speech, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethylergometrineEphedrine
Severe
How does the drug interact with Methergin Injection:
Taking Ephedrine with Methergin Injection may lead to an increase in the risk of high blood pressure.

How to manage the interaction:
Although taking Ephedrine with Methergin Injection may lead to an interaction, it can be taken if prescribed by the doctor. It is advised to maintain your blood pressure. Do not discontinue any medications without a doctor's advice.
MethylergometrinePhenylephrine
Severe
How does the drug interact with Methergin Injection:
Taking Phenylephrine with Methergin Injection can led to side effects like increased blood pressure.

How to manage the interaction:
Taking Phenylephrine with Methergin Injection can lead to an interaction but can be taken if prescribed by the doctor. It is advised to monitor your blood pressure regularly. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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METHYLERGOMETRINE-0.2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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METHYLERGOMETRINE-0.2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of Methergin Injection with Grapefruit and Grapefruit may lead to an increase in the effectiveness of Methergin Injection. Avoid or limit grapefruit and grapefruit juice consumption with Methergin Injection. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

  • Long walks can help to relieve stress, keep your body strong, and help in easy delivery.
  • Please take a little bit of Castrol oil as it is known to stimulate prostaglandin, which ripens the cervix and get labor started.
  • Some food like dates, raspberry tea leaves are known to ripen the cervix and get labor started.
  • Acupressure also stimulates labor and helps in delivery.

Habit Forming

No

Therapeutic Class

OXYTOCIC, UTEROTONIC, ECBOLIC

Methergin Injection 1 ml Substitute

Substitutes safety advice
  • Utergin 0.2 Injection 1's

    by Others

    14.90per tablet
  • MEM INJECTION 1ML

    by Others

    14.90per tablet
  • Ergagin Injection 1 ml

    by Others

    13.44per tablet
  • Methyler Injection 1 ml

    by Others

    10.80per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PROSTAGLANDINS
  • DESFLURANE
  • CYCLOPROPANE
  • DOPAMINE
  • EPINEPHRINE
  • HALOTHANE
  • ONDANSETRON
  • VASOPRESSIN
  • SEVOFLURANE

Special Advise

  • Methergin Injection 1 ml when given for induction of labor, stimulation of labor and prevention of vaginal bleeding after delivery of the baby especially after caesarean surgery. It must be administered only by the intravenous (IV) or intramuscular (IM) route under medical supervision in a hospital setting only. 

Disease/Condition Glossary

Postpartum haemorrhage: It is a serious but rare condition which causes excessive vaginal bleeding within one day after giving birth to the child. It happens mostly in cases of cesarean birth. When a baby is delivered, the uterus of the body contracts and forces out the placenta. After the placenta's delivery, these contractions put pressure on the bleeding vessels at the place where the placenta was attached, resulting in vaginal bleeding. It is normal to lose some amount of blood after delivery, but if a woman is losing more blood than normal, it can be dangerous. 

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