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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer

Steris Healthcare

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Metrotrex 7.5 Tablet

Metrotrex 7.5 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Metrotrex 7.5 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Metrotrex 7.5 Tablet contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Metrotrex 7.5 Tablet prevents and stops the growth of cancer cells, thereby helps treat cancer. Metrotrex 7.5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Metrotrex 7.5 Tablet may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Metrotrex 7.5 Tablet exactly as prescribed by the doctor; daily intake of Metrotrex 7.5 Tablet could lead to serious toxic effects. Do not take Metrotrex 7.5 Tablet if you are pregnant or breastfeeding. Metrotrex 7.5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Metrotrex 7.5 Tablet . Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Metrotrex 7.5 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Directions for Use

Metrotrex 7.5 Tablet should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Medicinal Benefits

Metrotrex 7.5 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Metrotrex 7.5 Tablet helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Metrotrex 7.5 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Metrotrex 7.5 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Metrotrex 7.5 Tablet prevents and stops the growth of cancer cells by interfering with DNA production. Metrotrex 7.5 Tablet may also be used to treat inflammatory bowel disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Metrotrex 7.5 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Drug Warnings

Do not take Metrotrex 7.5 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Metrotrex 7.5 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Metrotrex 7.5 Tablet may cause dizziness and fatigue, so drive only if you are alert. Take Metrotrex 7.5 Tablet exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Metrotrex 7.5 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateEtodolac
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Metrotrex 7.5 Tablet:
Co-administration of Etretinate with Metrotrex 7.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Metrotrex 7.5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateEtodolac
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Co-administration of Metrotrex 7.5 Tablet with etodolac can increase the level and effects of Metrotrex 7.5 Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Metrotrex 7.5 Tablet and etodolac, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateDicloxacillin
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Co-administration of Metrotrex 7.5 Tablet with dicloxacillin can increase the levels and effects of Metrotrex 7.5 Tablet. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Metrotrex 7.5 Tablet and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateLeflunomide
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Coadministration of leflunomide with Metrotrex 7.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Metrotrex 7.5 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MethotrexateTolmetin
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Coadministration of Metrotrex 7.5 Tablet with tolmetin can increase the levels and side effects of Metrotrex 7.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between tolmetin and Metrotrex 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Taking Human immunoglobulin with Metrotrex 7.5 Tablet may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Metrotrex 7.5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Combine use of hydroxychloroquine with Metrotrex 7.5 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Metrotrex 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexatePhenylbutazone
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Coadministration of phenylbutazone with Metrotrex 7.5 Tablet may increase the levels and side effects of phenylbutazone.

How to manage the interaction:
Although there is a possible interaction between phenylbutazone and Metrotrex 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateDexlansoprazole
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Co-administration of Metrotrex 7.5 Tablet with Dexlansoprazole can increase the levels and side effects of Metrotrex 7.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Metrotrex 7.5 Tablet and Dexlansoprazole, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, or body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateNitrous oxide
Severe
How does the drug interact with Metrotrex 7.5 Tablet:
Combine use of nitrous oxide with Metrotrex 7.5 Tablet may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Metrotrex 7.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.

Drug-Food Interactions

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METHOTREXATE-7.5MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-7.5MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Metrotrex 7.5 Tablet. Avoid taking caffeine while taking Metrotrex 7.5 Tablet. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Metrotrex 7.5 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

Metrotrex 7.5 Tablet works by suppressing the overactive immune system that is responsible for causing psoriasis. Metrotrex 7.5 Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Metrotrex 7.5 Tablet . Stop taking Metrotrex 7.5 Tablet and consult your doctor if you have diarrhoea. Do not take anti-diarrheal medicine on your own.

Metrotrex 7.5 Tablet can affect egg and sperm production and could lead to birth defects. Women of child-bearing potential and men using Metrotrex 7.5 Tablet must use effective contraception while on treatment with Metrotrex 7.5 Tablet and for at least six months after stopping the treatment. Metrotrex 7.5 Tablet can lead to infertility. Therefore male patients are advised to talk with their doctor regarding the possibility of sperm preservation before starting the treatment with Metrotrex 7.5 Tablet .

Metrotrex 7.5 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Metrotrex 7.5 Tablet may cause mouth sores. Stop taking Metrotrex 7.5 Tablet and consult your doctor if you have sores in the mouth. Your doctor may recommend folate supplements to treat mouth sores.

Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with Metrotrex 7.5 Tablet and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as Metrotrex 7.5 Tablet may cause infertility.
  • Metrotrex 7.5 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of Metrotrex 7.5 Tablet , call your doctor and ask if you should take the missed dose or not.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back, and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin, and pain.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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